Vol 8, No 34

Transglutaminase in neurological disease

Cancer’s new Achilles’ heel?

Identification of a novel p53 target, COL17A1, that inhibits breast cancer cell migration and invasion

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

Identification of a p53-repressed gene module in breast cancer cells

Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling

Loss of p16^INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β

Differentially expressed lncRNAs and miRNAs with associated ceRNA networks in aged mice with postoperative cognitive dysfunction

Detecting the genetic link between Alzheimer’s disease and obesity using bioinformatics analysis of GWAS data

Classical swine fever virus Shimen infection increases p53 signaling to promote cell cycle arrest in porcine alveolar macrophages

PKCθ utility in diagnosing c-KIT/DOG-1 double negative gastrointestinal stromal tumors

Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells

P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions

Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

Hepatic B cell leukemia-3 suppresses chemically-induced hepatocarcinogenesis in mice through altered MAPK and NF-κB activation

Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha

Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

MicroRNA profiling associated with non-small cell lung cancer: next generation sequencing detection, experimental validation, and prognostic value

Molecular and functional characterization of a new 3′ end KIT juxtamembrane deletion in a duodenal GIST treated with neoadjuvant Imatinib

Up-regulation of LINC00161 correlates with tumor migration and invasion and poor prognosis of patients with hepatocellular carcinoma

MicroRNA-610 suppresses osteosarcoma oncogenicity via targeting TWIST1 expression

N-Acetylcysteine breaks resistance to trastuzumab caused by MUC4 overexpression in human HER2 positive BC-bearing nude mice monitored by ⁸⁹Zr-Trastuzumab and ¹⁸F-FDG PET imaging

A phase 1 dose-escalation study of the oral histone deacetylase inhibitor abexinostat in combination with standard hypofractionated radiotherapy in advanced solid tumors

Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat

Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinogenesis in transgenic mice

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma

FoxR2 promotes glioma proliferation by suppression of the p27 pathway

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway

Combination of DESI2 and IP10 gene therapy significantly improves therapeutic efficacy against murine carcinoma

Eugenol alleviated breast precancerous lesions through HER2/ PI3K-AKT pathway-induced cell apoptosis and S-phase arrest

Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in in vitro and in vivo models of renal cell carcinoma

A novel EGFR-TKI inhibitor (cAMP-H₃BO₃ complex) combined with thermal therapy is a promising strategy to improve lung cancer treatment outcomes

Identification of precision treatment strategies for relapsed/ refractory multiple myeloma by functional drug sensitivity testing

Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways

Androgen receptor expression identifies patient with favorable outcome in operable triple negative breast cancer

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC

Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer

Copy number variations of circulating, cell-free DNA in urothelial carcinoma of the bladder patients treated with radical cystectomy: a prospective study

Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer

MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins

Increased expression of calponin 2 is a positive prognostic factor in pancreatic ductal adenocarcinoma

Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer

Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation

HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance

Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases

Coal tar pitch extract could induce chromosomal instability of human bronchial epithelial cells mediated by spindle checkpoint-related proteins

A genome-wide microRNA profiling indicates miR-424-5p and miR-503-5p as regulators of ALK expression in neuroblastoma

Polymorphisms of pri-miR-219-1 are associated with the susceptibility and prognosis of non-small cell lung cancer in a Northeast Chinese population

MiR-451 as a new tumor marker for gastric cancer

Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells

The roles of ING5 in gliomas: a good marker for tumorigenesis and a potential target for gene therapy

Alternative promotion and suppression of metastasis by JNK2 governed by its phosphorylation

Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis

Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma

Predictive factors of pathologic complete response in HER2-positive and axillary lymph node positive breast cancer after neoadjuvant paclitaxel, carboplatin plus with trastuzumab

Suppression of miR-16 promotes tumor growth and metastasis through reversely regulating YAP1 in human cholangiocarcinoma

Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group

PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition

Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma

Genomic analysis–integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

Microwave ablation combined with EGFR-TKIs versus only EGFR-TKIs in advanced NSCLC patients with EGFR-sensitive mutations

Long-term cigarette smoke exposure inhibits histone deacetylase 2 expression and enhances the nuclear factor-κB activation in skeletal muscle of mice

HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in CETP, ABCA1, APOC3, and GALNT2

Panobinostat, a histone deacetylase inhibitor, suppresses leptomeningeal seeding in a medulloblastoma animal model

Clinicopathological and prognostic significance of c-Met overexpression in breast cancer

IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation

CASP8 -652 6N insertion/deletion polymorphism and overall cancer risk: evidence from 49 studies

In vivo autophagy and biogenesis of autophagosomes within male haploid cells during spermiogenesis

Decitabine inhibits T cell proliferation via a novel TET2-dependent mechanism and exerts potent protective effect in mouse auto- and allo-immunity models

Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma

DNA methylation signature of long noncoding RNA genes during human pre-implantation embryonic development

Dysregulation of an X-linked primate-specific epididymal microRNA cluster in unexplained asthenozoospermia

Role of glucose metabolism related gene GLUT1 in the occurrence and prognosis of colorectal cancer

BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling

Oleoylethanolamide inhibits α-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells

Heptamethine carbocyanine DZ-1 dye for near-infrared fluorescence imaging of hepatocellular carcinoma

Marsdenia tenacissima extract overcomes Axl- and Met-mediated erlotinib and gefitinib cross-resistance in non-small cell lung cancer cells

Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function

A retrospective multicentric observational study of trastuzumab emtansine in HER2 positive metastatic breast cancer: a real-world experience

Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death

SOCS1 gene promoter methylation status is associated with in-stent restenosis after percutaneous coronary intervention

Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells

Necroptosis as a potential therapeutic target in multiple organ dysfunction syndrome

Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors

Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network

MicroRNA-107-5p suppresses non-small cell lung cancer by directly targeting oncogene epidermal growth factor receptor

Programmed differentiated natural killer cells kill leukemia cells by engaging SLAM family receptors

PLD1 overexpression promotes invasion and migration and function as a risk factor for Chinese glioma patients

Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK)

Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries

Patterns and clinical significance of cervical lymph node metastasis in papillary thyroid cancer patients with Delphian lymph node metastasis

The prevalence, subtypes and associated factors of hyperuricemia in lupus nephritis patients at chronic kidney disease stages 1–3

Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib

Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity

Mass spectrometry-based assay for the molecular diagnosis of glioma: concomitant detection of chromosome 1p/19q codeletion, and IDH1, IDH2, and TERT mutation status

Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity

Cbl-b predicts postoperative survival in patients with resectable pancreatic ductal adenocarcinoma

MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma

Morusin inhibits cell proliferation and tumor growth by downregulating c-Myc in human gastric cancer

The ketogenic diet is not feasible as a therapy in a CD-1 nu/nu mouse model of renal cell carcinoma with features of Stauffer’s syndrome

ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration

Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor α2 antibody by fluorescence molecular tomography

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations

Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers

Integration of ALV into CTDSPL and CTDSPL2 genes in B-cell lymphomas promotes cell immortalization, migration and survival

Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review

Bevacizumab combined with chemotherapy for glioblastoma: a meta-analysis of randomized controlled trials

Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies

Clinical outcomes of WBRT plus EGFR-TKIs versus WBRT or TKIs alone for the treatment of cerebral metastatic NSCLC patients: a meta-analysis

Docetaxel versus docetaxel plus cisplatin for non-small-cell lung cancer: a meta-analysis of randomized clinical trials

Meta-analysis of the incidence and risks of interstitial lung disease and QTc prolongation in non-small-cell lung cancer patients treated with ALK inhibitors

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis

Combination therapy versus pharmacotherapy, endoscopic variceal ligation, or the transjugular intrahepatic portosystemic shunt alone in the secondary prevention of esophageal variceal bleeding: a meta-analysis of randomized controlled trials

Association of P73 polymorphisms with susceptibilities of cervical carcinoma: a meta-analysis

Systematic review and meta-analysis of the efficacy of breast conservation therapy followed by radiotherapy in four breast cancer subtypes

Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects

Lack of association between NAT2 polymorphism and prostate cancer risk: a meta-analysis and trial sequential analysis

Prognostic significance of neutrophil-to-lymphocyte ratio in patients with malignant pleural mesothelioma: a meta-analysis

Evaluation on efficacy and safety of the addition of X-knife therapy to gefitinib in NSCLC patients with symptomatic brain metastases

Features and risk factors of carotid atherosclerosis in a population with high stroke incidence in China

Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage

Different long-term oncologic outcomes after radical surgical resection for neuroendocrine carcinoma and adenocarcinoma of the stomach

Efficacy and safety of a reduced calcineurin inhibitor dose combined with mycophenolate mofetil in liver transplant patients with chronic renal dysfunction

Preoperative monocyte-lymphocyte and neutrophil-lymphocyte but not platelet-lymphocyte ratios are predictive of clinical outcomes in resected patients with non-metastatic Siewert type II/III adenocarcinoma of esophagogastric junction: a prospective cohort study (the AMONP corhort)

Biomarker analysis of the phase 3 TORCH trial for first line erlotinib versus chemotherapy in advanced non-small cell lung cancer patients

The application of IS6110-baced loop-mediated isothermal amplification (LAMP) in the early diagnosis of tuberculous meningitis

Association of pre-operative depressive and anxiety symptoms with five-year survival of glioma and meningioma patients: a prospective cohort study

Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma

TOP2A, GGH, and PECAM1 are associated with hematogenous, lymph node, and peritoneal recurrence in stage II/III gastric cancer patients enrolled in the ACTS-GC study

Preoperative assessment of mitral valve abnormalities in left atrial myxoma patients using cardiac CT

Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

Comparison among fertility-sparing therapies for well differentiated early-stage endometrial carcinoma and complex atypical hyperplasia

Targeted therapies for gastric cancer: failures and hopes from clinical trials

Treatments of traumatic neuropathic pain: a systematic review

Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies

Promising landscape for regulating macrophage polarization: epigenetic viewpoint

The role of autophagy in hepatocellular carcinoma: friend or foe

Augmented expression of polo-like kinase 1 indicates poor clinical outcome for breast patients: a systematic review and meta-analysis

Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials

The prognostic value of long noncoding RNAs in prostate cancer: a systematic review and meta-analysis

Insights from animal models of bladder cancer: recent advances, challenges, and opportunities

Vitamin K and its analogs: Potential avenues for prostate cancer management

Formation, function, and exhaustion of notochordal cytoplasmic vacuoles within intervertebral disc: current understanding and speculation

The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy

The efficacy of anti-PD-1/PD-L1 therapy and its comparison with EGFR-TKIs for advanced non-small-cell lung cancer

Epigenetic regulation during the differentiation of stem cells to germ cells

Implementation and utilization of the molecular tumor board to guide precision medicine

p53, p63 and p73 in the wonderland of S. cerevisiae

The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

Pseudoprogression in microsatellite instability-high colorectal cancer during treatment with combination T cell mediated immunotherapy: a case report and literature review

Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed

Correction: Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis