Oncotarget

Research Papers:

Autosomal InDel polymorphisms for population genetic structure and differentiation analysis of Chinese Kazak ethnic group

Tingting Kong, Yahao Chen, Yuxin Guo, Yuanyuan Wei, Xiaoye Jin, Tong Xie, Yuling Mu, Qian Dong, Shaoqing Wen, Boyan Zhou, Li Zhang, Chunmei Shen and Bofeng Zhu _

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Oncotarget. 2017; 8:56651-56658. https://doi.org/10.18632/oncotarget.17838

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Abstract

Tingting Kong1,2,3, Yahao Chen4, Yuxin Guo1,2,5, Yuanyuan Wei1,2, Xiaoye Jin1,2,5, Tong Xie3, Yuling Mu5, Qian Dong5, Shaoqing Wen6, Boyan Zhou6,7, Li Zhang8, Chunmei Shen9 and Bofeng Zhu1,2,3

1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, P. R. China

2Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi’an Jiaotong University, Xi’an, P. R. China

3Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, P. R. China

4Laboratory Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, P. R. China

5College of Medicine & Forensics, Xi’an Jiaotong University Health Science Center, Xi’an, P. R. China

6State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China

7State Key Laboratory of Genetic Engineering and Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, P. R. China

8Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P. R. China

9Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, P. R. China

Correspondence to:

Bofeng Zhu, email: [email protected]

Keywords: Kazak group, InDel, population genetics, interpopulation differentiation, phylogenetic tree

Received: March 08, 2017     Accepted: April 12, 2017     Published: May 12, 2017

ABSTRACT

In the present study, we assessed the genetic diversities of the Chinese Kazak ethnic group on the basis of 30 well-chosen autosomal insertion and deletion loci and explored the genetic relationships between Kazak and 23 reference groups. We detected the level of the expected heterozygosity ranging from 0.3605 at HLD39 locus to 0.5000 at HLD136 locus and the observed heterozygosity ranging from 0.3548 at HLD39 locus to 0.5283 at HLD136 locus. The combined power of discrimination and the combined power of exclusion for all 30 loci in the studied Kazak group were 0.999999999999128 and 0.9945, respectively. The dataset generated in this study indicated the panel of 30 InDels was highly efficient in forensic individual identifcation but may not have enough power in paternity cases. The results of the interpopulation differentiations, PCA plots, phylogenetic trees and STRUCTURE analyses showed a close genetic affiliation between the Kazak and Uigur group.


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