Oncotarget

Research Papers:

Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity

Bing Niu _, Mengying Zhang, Pu Du, Li Jiang, Rui Qin, Qiang Su, Fuxue Chen, Dongshu Du, Yilai Shu and Kuo-Chen Chou

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Oncotarget. 2017; 8:57149-57162. https://doi.org/10.18632/oncotarget.19169

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Abstract

Bing Niu1,3,*, Mengying Zhang1,*, Pu Du4,*, Li Jiang1, Rui Qin6, Qiang Su1, Fuxue Chen1, Dongshu Du1,7, Yilai Shu5 and Kuo-Chen Chou2,3

1Shanghai Key Laboratory of Bio-Energy Crops, College of Life Science, Shanghai University, Shanghai, 200444, China

2Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, 610054, China

3Gordon Life Science Institute, Boston, MA 02478, USA

4Department of Neurology, The First People's Hospital of Foshan, Foshan, 528000, China

5Department of Otolaryngology–Head and Neck Surgery, Eye and Ear, Nose, Throat, Hospital, Shanghai Medical College, Fudan University, Shanghai, 200031, China

6Department of Gynecology, Affiliated Minzu Hospital of Guangxi Medical University, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530001, China

7Department of Life Science, Heze University, Heze, Shandong, 274500, China

*These authors contributed equally to this work

Correspondence to:

Bing Niu, email: [email protected], [email protected]

Fuxue Chen, email: [email protected]

Dongshu Du, email: [email protected]

Yilai Shu, email: [email protected]

Keywords: Alzheimer’s disease (AD), floribundiquinone B (FB), plant inhibitor, acetylcholinesterase (AChE), fluorescence quenching

Received: May 07, 2017     Accepted: June 28, 2017     Published: July 11, 2017

ABSTRACT

Being a neurodegenerative disorder, Alzheimer’s disease (AD) is the one of the most terrible diseases. And acetylcholinesterase (AChE) is considered as an important target for treating AD. Acetylcholinesterase inhibitors (AChEI) are considered to be one of the effective drugs for the treatment of AD. The aim of this study is to find a novel potential AChEI as a drug for the treatment of AD. In this study, instead of using the synthetic compounds, we used those extracted from plants to investigate the interaction between floribundiquinone B (FB) and AChE by means of both the experimental approach such as fluorescence spectra, ultraviolet-visible (UV-vis) absorption spectrometry, circular dichroism (CD) and the theoretical approaches such as molecular docking. The findings reported here have provided many useful clues and hints for designing more effective and less toxic drugs against Alzheimer’s disease.


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