Oncotarget

Research Papers:

This article has been corrected. Correction in: Oncotarget. 2019; 10:1474.

Up-regulation of LINC00161 correlates with tumor migration and invasion and poor prognosis of patients with hepatocellular carcinoma

Li-Chao Xu, Quan-Ning Chen, Xi-Qiang Liu, Xiao-Ming Wang, Qi-Meng Chang, Qi Pan, Lu Wang and Yi-Lin Wang _

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Oncotarget. 2017; 8:56168-56173. https://doi.org/10.18632/oncotarget.17040

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Abstract

Li-Chao Xu1,*, Quan-Ning Chen3,*, Xi-Qiang Liu4,*, Xiao-Ming Wang5, Qi-Meng Chang6, Qi Pan2, Lu Wang2 and Yi-Lin Wang2

1Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

2Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

3Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China

4Department of Hepatobiliary-Pancreatic Surgery, Hangzhou, 310014, China

5Department of Hepatobiliary Surgery, Yi Ji-shan Hospital, Wan Nan Medical College, Wuhu, 241000, China

6Department of General Surgery, Minhang Hospital, Fudan University, Shanghai, 201199, China

*These authors contributed equally to this work

Correspondence to:

Yi-Lin Wang, email: [email protected]

Qi Pan, email: [email protected]

Lu Wang, email: [email protected]

Keywords: LINC00161, hepatocellular carcinoma, prognosis, tumor cell migration, invasion

Received: March 03, 2017     Accepted: April 03, 2017     Published: April 11, 2017

ABSTRACT

Accumulating evidence suggested that long non-coding RNAs (lncRNAs) play essential roles in various biological processes, including tumorigenesis. Aberrant expression of LINC00161 has been reported in some cancer types, however, the association of LINC00161 and hepatocellular carcinoma (HCC) has not been evaluated. Here, we measured the expression of LINC00161 in HCC tissues and corresponding normal liver tissues using real-time PCR. The result showed that the expression level of LINC00161 was significantly higher in HCC tissues. Further analysis indicated that HCC patients with higher LINC00161 expression have shorter survival. Multivariate Cox regression analysis showed that LINC00161 expression was an independent prognostic factor for the overall survival. Furthermore, our result indicated that knock-down of LINC00161 can significantly inhibit liver cancer cell migration and invasion. The present work indicated that LINC00161 might serve as an oncogenic gene and play a pivotal role in promoting tumor migration and invasion in HCC. Our work implicates the promising effect of LINC00161 on the prognosis of HCC.


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