Oncotarget

Research Papers:

Polymorphisms of pri-miR-219-1 are associated with the susceptibility and prognosis of non-small cell lung cancer in a Northeast Chinese population

Chang Zheng, Xuelian Li, Lingzi Xia, Xue Fang, Xiaowei Quan, Zhihua Yin, Yuxia Zhao and Baosen Zhou _

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Oncotarget. 2017; 8:56533-56541. https://doi.org/10.18632/oncotarget.17035

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Abstract

Chang Zheng1,2, Xuelian Li1,2, Lingzi Xia1,2, Xue Fang1,2, Xiaowei Quan1,2, Zhihua Yin1,2, Yuxia Zhao3 and Baosen Zhou1,2

1Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China

2Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Department of Education, Liaoning, China

3Department of Radiotherapy, The Fourth Affiliated Hospital of China Medical University, Shenyang, China

Correspondence to:

Baosen Zhou, email: [email protected]

Keywords: SNP, miRNA, NSCLC, susceptibility, prognosis

Received: January 17, 2017     Accepted: March 21, 2017     Published: April 11, 2017

ABSTRACT

Occurrence and development of non-small cell lung cancer (NSCLC) is a complex process affected both by gene and environment. Single nucleotide polymorphisms (SNPs) in microRNAs’ (miRNAs) biogenesis influenced the expression of mature miRNAs, further had an impact on risk of NSCLC. Our study focused on the correlation between rs213210, rs421446 or rs107822 polymorphisms in pri-miR-219-1 and susceptibility or prognosis of NSCLC in Chinese. A case-control study of 405 new-diagnosis patients and 405 controls was performed. Ten ml venous blood from each subject was collected for genotype test via using TaqMan allelic discrimination methodology and SPSS was performed for statistical analyses. We found that CC genotype in rs213210 (OR=3.462, 95%CI=2.222-5.394, P<0.001) compared with TT genotype and GG genotype in rs107822 (OR=3.553, 95%CI=2.329-5.419, P<0.001) compared with AA genotype showed significantly increased risk of NSCLC. Haplotype analysis showed that pri-miR-219-1 haplotype Crs213210Crs421446Grs107822 was a dangerous haplotype for lung cancer. And polymorphisms in pri-miR-219-1 have showed no relationship with overall survival of NSCLC. Overall, these findings firstly showed that rs213210 and rs107822 could be meaningful as genetic markers for lung cancer risk.


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