Treatments of traumatic neuropathic pain: a systematic review

Chenglun Yao, Xijie Zhou, Bin Zhao, Chao Sun, Keshav Poonit and Hede Yan _

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Oncotarget. 2017; 8:57670-57679. https://doi.org/10.18632/oncotarget.16917

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Chenglun Yao1, Xijie Zhou1, Bin Zhao1, Chao Sun1, Keshav Poonit1 and Hede Yan1

1Department of Orthopedics (Division of Plastic and Hand Surgery), The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China

Correspondence to:

Hede Yan, email: [email protected]

Keywords: traumatic neuropathic pain, neuroma, treatment modality, pain management

Received: February 08, 2017    Accepted: March 21, 2017    Published: April 07, 2017


Traumatic neuropathic pain caused by traumatic neuroma has long been bothering both doctors and patients, the mechanisms of traumatic neuropathic pain are widely discussed by researchers and the treatment is challenging. Clinical treatment of painful neuroma is unclear. Numerous treatment modalities have been introduced by experts in this field. However, there is still no single standard recognized treatment.

Different forms of treatments have been tested in animals and humans, but pharmacotherapies (antidepressants, antiepileptics) remain the basis of traumatic neuropathic pain management. For intractable cases, nerve stump transpositions into a muscle, vein or bone are seen as traditional surgical procedures which provide a certain degree of efficacy. Novel surgical techniques have emerged in recent years, such as tube guided nerve capping, electrical stimulation and adipose autograft have substantially enriched the abundance of the treatment for traumatic neuropathic pain.

Several treatments show advantages over the others in terms of pain relief and prevention of neuroma formation, making it difficult to pick out a single modality as the reference. An effective and standardized treatment for traumatic neuropathic pain would provide better choice for researchers and clinical workers.

In this review, we summarized current knowledge on the treatment of traumatic neuropathic pain, and found a therapeutic strategy for this intractable pain. We tried to provide a useful guideline for choosing the right modality in management of traumatic neuropathic pain.

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