Oncotarget

Meta-Analysis:

Meta-analysis of the incidence and risks of interstitial lung disease and QTc prolongation in non-small-cell lung cancer patients treated with ALK inhibitors

Liping Lin _, Juanjuan Zhao, Ning Kong, Yan He, Jiazhu Hu, Fuxi Huang, Jianjun Han and Xiaolong Cao

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Oncotarget. 2017; 8:57379-57385. https://doi.org/10.18632/oncotarget.18283

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Abstract

Liping Lin1,4,*, Juanjuan Zhao2,*, Ning Kong3,4, Yan He1,4, Jiazhu Hu1,4, Fuxi Huang1,4, Jianjun Han1,4 and Xiaolong Cao1,4

1Department of Oncology, Panyu Central Hospital, Guangzhou, 511400, China

2School of Nursing, Sun Yat-sen University, Guangzhou, 510000, China

3Department of Ophthalmology, Panyu Central Hospital, Guangzhou, 511400, China

4Cancer Institute of Panyu, Guangzhou, 511400, China

*These authors contributed equally to this work

Correspondence to:

Liping Lin, email: [email protected]

Keywords: ALK-TKIs, interstitial lung disease, QTc prolongation, non-small-cell lung cancer, meta-analysis

Received: April 16, 2017     Accepted: May 03, 2017     Published: May 29, 2017

ABSTRACT

Background: To conduct a systematic review and meta-analysis to assess the overall incidence and risk of interstitial lung disease (ILD) and QTc prolongation associated with anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (-TKIs) in non-small-cell lung cancer (NSCLC) patients.

Results: A total of 1,770 patients from 8 clinical trials were included. The incidences of high-grade ILD and QTc prolongation was 2.5% (95% CI 1.7-3.6%), and 2.8% (95% CI 1.8-4.3%), respectively. Meta-analysis demonstrated that the use of ALK-TKIs in NSCLC patients significantly increased the risk of developing high-grade ILD (Peto OR, 3.27, 95%CI: 1.18–9.08, p = 0.023) and QTc prolongation (Peto OR 7.51, 95% CI, 2.16–26.15; p = 0.002) in comparison with chemotherapy alone.

Materials and Methods: A systematic literature search was performed to identify related citations up to January 31, 2017. Data were extracted, and summary incidence rates, Peto odds ratios (Peto ORs), and 95% confidence intervals (CIs) were calculated.

Conclusions: The use of ALK-TKIs significantly increases the risk of developing high-grade ILD and QTc prolongation in lung cancer patients. Clinicians should pay attention to the risks of severe ILD and QTc prolongation with the administration of these drugs.


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