Vol 7, No 22

Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity

Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner

CXCL16 regulates cisplatin-induced acute kidney injury

microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB

The impact of the MYB-NFIB fusion proto-oncogene in vivo

Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice

Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival

Galectin-1 is essential for efficient liver regeneration following hepatectomy

Subanesthetic isoflurane relieves zymosan-induced neutrophil inflammatory response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling

Caffeic acid ameliorates colitis in association with increased Akkermansia population in the gut microbiota of mice

Anti-inflammatory effects of interleukin-23 receptor cytokine-binding homology region rebalance T cell distribution in rodent collagen-induced arthritis

MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer

Inhibition of c-FLIPL expression by miRNA-708 increases the sensitivity of renal cancer cells to anti-cancer drugs

Cancer-selective cytotoxic Ca²⁺ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid

Identification of novel long non-coding RNAs deregulated in hepatocellular carcinoma using RNA-sequencing

Prostate tumor overexpressed-1, in conjunction with human papillomavirus status, predicts outcome in early-stage human laryngeal squamous cell carcinoma

A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-κB regulates head and neck squamous cell carcinoma proliferation

Cell line with endogenous EGFR^vIII expression is a suitable model for research and drug development purposes

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

Characterization of cervical cancer stem cell-like cells: phenotyping, stemness, and human papilloma virus co-receptor expression

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma

The association between the TERT rs2736100 AC genotype and reduced risk of upper tract urothelial carcinomas in a Han Chinese population

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis

MicroRNA-371-5p targets SOX2 in gastric cancer

Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin

IL-10 control of CD11c+ myeloid cells is essential to maintain immune homeostasis in the small and large intestine

STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia

Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells

A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II

Mutational spectrum and risk stratification of intermediate-risk acute myeloid leukemia patients based on next-generation sequencing

The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis

TR4 nuclear receptor enhances the cisplatin chemo-sensitivity via altering the ATF3 expression to better suppress HCC cell growth

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer

Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro

Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17

Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma

The DNA resection protein CtIP promotes mammary tumorigenesis

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation

Niclosamide enhances abiraterone treatment via inhibition of androgen receptor variants in castration resistant prostate cancer

Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells

Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides

The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor

DNA polymerase iota (Pol ι) promotes invasion and metastasis of esophageal squamous cell carcinoma

A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway

Visfatin is involved in promotion of colorectal carcinoma malignancy through an inducing EMT mechanism

Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants

Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth

GABR_A3 promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases

BLM promotes the activation of Fanconi Anemia signaling pathway

Reduction of microRNA-184 by E6 oncoprotein confers cisplatin resistance in lung cancer via increasing Bcl-2

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

Predicting cancer-relevant proteins using an improved molecular similarity ensemble approach

Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma

miR-1207-5p suppresses lung cancer growth and metastasis by targeting CSF1

Comprehensive analysis of lncRNA expression profiles reveals a novel lncRNA signature to discriminate nonequivalent outcomes in patients with ovarian cancer

Necrosis-inducing peptide has the beneficial effect on killing tumor cells through neuropilin (NRP-1) targeting

Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells

The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer

Hepatocyte SLAMF3 reduced specifically the multidrugs resistance protein MRP-1 and increases HCC cells sensitization to anti-cancer drugs

Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients

Cardiotoxicity as indicated by LVEF and troponin T sensitivity following two anthracycline-based regimens in lymphoma: Results from a randomized prospective clinical trial

Phase I clinical study of RG7356, an anti-CD44 humanized antibody, in patients with acute myeloid leukemia

UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo

The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro

Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy

Sequential intensified conditioning followed by prophylactic DLI could reduce relapse of refractory acute leukemia after allo-HSCT

The levels of serine proteases in colon tissue interstitial fluid and serum serve as an indicator of colorectal cancer progression

Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo

Expression and prognostic significance of CCL11/CCR3 in glioblastoma

Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer

Characterization of selective and potent PI3Kδ inhibitor (PI3KDIN- 015) for B-Cell malignances

Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3

Palmitoylation regulates the intracellular trafficking and stability of c-Met

MERTK as a novel therapeutic target in head and neck cancer

Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity

Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5

Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma

TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting

HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer

Genetic association of deleted in colorectal carcinoma variants with breast cancer risk: A case-control study

COMMD7 is correlated with a novel NF-κB positive feedback loop in hepatocellular carcinoma

Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium

MUC1 stimulates EGFR expression and function in endometrial cancer

Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease

QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis

Predictive parameters for selection of electronic tissue compensation radiotherapy in early-stage breast cancer patients after breast-conserving surgery

Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia

A novel TP53 variant (rs78378222 A > C) in the polyadenylation signal is associated with increased cancer susceptibility: evidence from a meta-analysis

Optical and nuclear imaging of glioblastoma with phosphatidylserine-targeted nanovesicles

Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells

Potential options for managing LOX+ ER- breast cancer patients

Predictive microRNAs for lymph node metastasis in endoscopically resectable submucosal colorectal cancer

mTOR pathway activation is a favorable prognostic factor in human prostate adenocarcinoma

Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers

Survival in acute myeloid leukemia is associated with NKp44 splice variants

UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2

RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2

Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock

Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo

Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells

Quantitative assessment of the CD26+ leukemic stem cell compartment in chronic myeloid leukemia: patient-subgroups, prognostic impact, and technical aspects

Real-time monitoring of tumor progression and drug responses in a preclinical mouse model of prostate cancer

High post-treatment serum levels of soluble programmed cell death ligand 1 predict early relapse and poor prognosis in extranodal NK/T cell lymphoma patients

High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model

Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling

Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer

A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model

NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling

Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src

Hepatitis B virus X protein amplifies TGF-β promotion on HCC motility through down-regulating PPM1a

miR186 suppresses prostate cancer progression by targeting Twist1

AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer

Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4

SSRI use and clinical outcomes in epithelial ovarian cancer

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition

Immunomodulatory role of bitter melon extract in inhibition of head and neck squamous cell carcinoma growth

Inflammatory indexes as predictors of prognosis and bevacizumab efficacy in patients with metastatic colorectal cancer

Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells

Long-term outcomes of imatinib in patients with FIP1L1/ PDGFRA associated chronic eosinophilic leukemia: experience of a single center in China

In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes

c-MYC inhibition impairs hypoxia response in glioblastoma multiforme

The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer

MiR-17-5p regulates cell proliferation and migration by targeting transforming growth factor-β receptor 2 in gastric cancer

Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle

Effective treatment of ductal carcinoma in situ with a HER-2- targeted alpha-particle emitting radionuclide in a preclinical model of human breast cancer

Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1

Thalidomide enhanced the efficacy of CHOP chemotherapy in the treatment of diffuse large B cell lymphoma: A phase II study

The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals

Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1/PD-L1 axis activating intracellular AKT/mTOR pathway in tumor cells

Kaposi’s sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling

Risk of recurrence and conditional survival in complete responders treated with TKIs plus or less locoregional therapies for metastatic renal cell carcinoma

Treatment outcome of nimotuzumab plus chemotherapy in advanced cancer patients: a single institute experience

Effect of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy alone in nasopharyngeal carcinoma

Meta-analysis comparing maintenance strategies with continuous therapy and complete chemotherapy-free interval strategies in the treatment of metastatic colorectal cancer

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy

Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future

The application of the fibroblast activation protein α-targeted immunotherapy strategy