Potential options for managing LOX+ ER- breast cancer patients
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Yong Han1,*, Shenyi Lian2,*, Xingran Cui3, Kexin Meng4, Balázs Győrffy5,6, Tao Jin7, Dongsheng Huang1
1Clinical Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou, China
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, China
3Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA
4Department of Thyroid Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China
5Momentum Cancer Biomarker Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
6Second Department of Pediatrics, Semmelweis University, Budapest, Hungary
7Department of Cardiothoracic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China
*These authors contributed equally to this work
Tao Jin, email: firstname.lastname@example.org
Dongsheng Huang, email: email@example.com
Keywords: LOX, estrogen recepter, EMT, chemoresistance, bisphosphonates
Received: September 01, 2015 Accepted: April 11, 2016 Published: April 28, 2016
Overexpression of lysyl oxidase (LOX) is often observed in estrogen receptor negative (ER–) breast cancer patients with bone metastasis. In the present bioinformatics study, we observed that LOX is a prognostic factor for poor progression free survival in patients with ER– breast cancer. LOX overexpression was positively correlated with resistance to radiation, doxorubin and mitoxantrone, but negatively correlated with resistance to bisphosphonate, PARP1 inhibitors, cisplatin, trabectedin and gemcitabine. LOX overexpression was also associated with EMT and stemness of cancer cells, which leads to chemotherapeutic resistance and poor outcome in ER– patients. Although we suggest several therapeutic interventions that may help in the management of LOX+ ER– breast cancer patients, experiments to validate the function of LOX in ER– breast cancer are still needed.
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