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About The Cover

The cover for issue 61 of Oncotarget features Figure 2, "Pedigrees of the families 6006 and 6043 showing the haplotypes of selected family members (the families’ risk haplotype is indicated in grey shade)," from Jiao, et al.

Table of Contents

Editorial

Therapy of polycythemia vera: is it time to change

https://doi.org/10.18632/oncotarget.22282
102759-102760
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Lck activation: puzzling the pieces together

https://doi.org/10.18632/oncotarget.22309
102761-102762
PDF  |  How to cite

Immune control in chronic myeloid leukemia

https://doi.org/10.18632/oncotarget.22279
102763-102764
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SMX makes the cut in genome stability

https://doi.org/10.18632/oncotarget.22420
102765-102766
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Avelumab demonstrates promise in advanced NSCLC

https://doi.org/10.18632/oncotarget.22418
102767-102768
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Priority Research Papers

PHIP a novel candidate breast cancer susceptibility locus on 6q141

https://doi.org/10.18632/oncotarget.21800
102769-102782
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Loss of p53inducible long noncoding RNA LINC01021 increases chemosensitivity

https://doi.org/10.18632/oncotarget.22245
102783-102800
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Gerotarget (Focus on Aging)

Prostaglandin I2 is responsible for ameliorating prostaglandin E2 stress in stimulating the expression of tumor necrosis factor α in a βamyloid protein dependent mechanism

https://doi.org/10.18632/oncotarget.18462
102801-102819
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Pathology

Chronic inflammation and apoptosis propagate in ischemic cerebellum and heart of nonhuman primates

https://doi.org/10.18632/oncotarget.18330
102820-102834
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Immunology

Regulatory T cells characterized by low Id3 expression are highly suppressive and accumulate during chronic infection

https://doi.org/10.18632/oncotarget.22159
102835-102851
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Research Papers

Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells

https://doi.org/10.18632/oncotarget.9913
102852-102867
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

https://doi.org/10.18632/oncotarget.22263
102868-102879
Abstract  |  PDF  |  Full Text  |  How to cite

Prognostic effect of adjuvant chemoradiotherapy for patients with gastric cancer: an updated evidence of randomized controlled trials

https://doi.org/10.18632/oncotarget.21983
102880-102887
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Mutational profile of primary breast diffuse large Bcell lymphoma

https://doi.org/10.18632/oncotarget.21986
102888-102897
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Unique signalling connectivity of FGFR3TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis

https://doi.org/10.18632/oncotarget.22048
102898-102911
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Highgrade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism

https://doi.org/10.18632/oncotarget.22076
102912-102922
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress

https://doi.org/10.18632/oncotarget.22084
102923-102933
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Xenobioticinduced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers

https://doi.org/10.18632/oncotarget.22173
102934-102947
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Delineating the distinct role of AKT in mediating cell survival and proliferation induced by CD154 and IL4/IL21 in chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.22292
102948-102964
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Efficacy and toxicity of imageguided intensitymodulated radiation therapy combined with doseescalated brachytherapy for stage IIB cervical cancer

https://doi.org/10.18632/oncotarget.22434
102965-102973
Abstract  |  PDF  |  Full Text  |  How to cite

Alphaketoglutarate suppresses the NFκBmediated inflammatory pathway and enhances the PXRregulated detoxification pathway

https://doi.org/10.18632/oncotarget.16875
102974-102988
Abstract  |  PDF  |  Full Text  |  How to cite

Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF1α

https://doi.org/10.18632/oncotarget.19900
102989-103003
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

LincRNA FEZF1AS1 contributes to the proliferation of LAD cells by silencing p57 expression

https://doi.org/10.18632/oncotarget.21265
103004-103013
Abstract  |  PDF  |  Full Text  |  How to cite

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor dasatinib in thyroid cancer

https://doi.org/10.18632/oncotarget.20488
103014-103031
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of SPOP related metabolic pathways in prostate cancer

https://doi.org/10.18632/oncotarget.21460
103032-103046
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Treatment and survival outcomes of lobular carcinoma in situ of the breast: a SEER population based study

https://doi.org/10.18632/oncotarget.21461
103047-103054
Abstract  |  PDF  |  Full Text  |  How to cite

Optimization of EGFR mutation detection by the fullyautomated qPCRbased Idylla system on tumor tissue from patients with nonsmall cell lung cancer

https://doi.org/10.18632/oncotarget.21476
103055-103062
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.21523
103063-103076
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Neutrophiltolymphocyte ratio predicts survival in European patients with hepatocellular carcinoma administered sorafenib

https://doi.org/10.18632/oncotarget.21528
103077-103086
Abstract  |  PDF  |  Full Text  |  How to cite

Crotonoside exhibits selective postinhibition effect in AML cells via inhibition of FLT3 and HDAC3/6

https://doi.org/10.18632/oncotarget.20710
103087-103099
Abstract  |  PDF  |  Full Text  |  How to cite

A framework for exploring associations between biomedical terms in PubMed

https://doi.org/10.18632/oncotarget.21532
103100-103107
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Predictors of overall survival in metastatic castrationresistant prostate cancer patients receiving [177Lu]LuPSMA617 radioligand therapy

https://doi.org/10.18632/oncotarget.21600
103108-103116
Abstract  |  PDF  |  Full Text  |  How to cite

Predictive clinical parameters for the response of nivolumab in pretreated advanced nonsmallcell lung cancer

https://doi.org/10.18632/oncotarget.21602
103117-103128
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The combination of temozolomideirinotecan regresses a doxorubicinresistant patientderived orthotopic xenograft PDOX nudemouse model of recurrent Ewing’s sarcoma with a FUSERG fusion and CDKN2A deletion: Direction for thirdline patient therapy

https://doi.org/10.18632/oncotarget.20789
103129-103136
Abstract  |  PDF  |  Full Text  |  How to cite

Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B

https://doi.org/10.18632/oncotarget.21663
103137-103153
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inhibition of PTEN activity aggravates cisplatininduced acute kidney injury

https://doi.org/10.18632/oncotarget.20790
103154-103166
Abstract  |  PDF  |  Full Text  |  How to cite

Cucurbitacin B and SCH772984 exhibit synergistic antipancreatic cancer activities by suppressing EGFR PI3K/Akt/mTOR STAT3 and ERK signaling

https://doi.org/10.18632/oncotarget.21704
103167-103181
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A niche that triggers aggressiveness within BRCA1IRIS overexpressing triple negative tumors is supported by reciprocal interactions with the microenvironment

https://doi.org/10.18632/oncotarget.20892
103182-103206
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PIK3CAH1047Rinduced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors

https://doi.org/10.18632/oncotarget.21732
103207-103222
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liverkidney syndrome

https://doi.org/10.18632/oncotarget.21735
103223-103235
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microgliamediated neuroinflammation in traumatic brain injury

https://doi.org/10.18632/oncotarget.21139
103236-103260
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MiR129 blocks estrogen induction of NOTCH signaling activity in breast cancer stemlike cells

https://doi.org/10.18632/oncotarget.21143
103261-103273
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Bone marrow fibrosis in chronic myelomonocytic leukemia is associated with increased megakaryopoiesis splenomegaly and with a shorter median time to disease progression

https://doi.org/10.18632/oncotarget.21870
103274-103282
Abstract  |  PDF  |  Full Text  |  How to cite

AntiNYESO1 autoantibody may be a tumor marker for intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.22464
103283-103289
Abstract  |  PDF  |  Full Text  |  How to cite

Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using labelfree quantitative proteomics

https://doi.org/10.18632/oncotarget.21179
103290-103301
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Regulation of epithelialmesenchymal transition and metastasis by TGFβ Pbodies and autophagy

https://doi.org/10.18632/oncotarget.21871
103302-103314
Abstract  |  PDF  |  Full Text  |  How to cite

Plasmatic miR210 miR221 and miR1233 profile: potential liquid biopsies candidates for renal cell carcinoma

https://doi.org/10.18632/oncotarget.21733
103315-103326
Abstract  |  PDF  |  Full Text  |  How to cite

A prognostic 4gene expression signature for patients with HER2negative breast cancer receiving taxane and anthracyclinebased chemotherapy

https://doi.org/10.18632/oncotarget.21872
103327-103339
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Characterization of epithelialmesenchymal transition intermediate/hybrid phenotypes associated to resistance to EGFR inhibitors in nonsmall cell lung cancer cell lines

https://doi.org/10.18632/oncotarget.21132
103340-103363
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway

https://doi.org/10.18632/oncotarget.21873
103364-103374
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Prioritizing chronic obstructive pulmonary disease COPD candidate genes in COPDrelated networks

https://doi.org/10.18632/oncotarget.21874
103375-103384
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Evaluation of the association of UBASH3A and SYNGR1 with rheumatoid arthritis and disease activity and severity in Han Chinese

https://doi.org/10.18632/oncotarget.21875
103385-103392
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

https://doi.org/10.18632/oncotarget.21900
103393-103409
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Ovarian cancer variant rs2072590 is associated with HOXD1 and HOXD3 gene expression

https://doi.org/10.18632/oncotarget.21902
103410-103414
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

https://doi.org/10.18632/oncotarget.21910
103415-103427
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Differential expression of cMet between primary and metastatic sites in clearcell renal cell carcinoma and its association with PDL1 expression

https://doi.org/10.18632/oncotarget.21952
103428-103436
Abstract  |  PDF  |  Full Text  |  How to cite

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue

https://doi.org/10.18632/oncotarget.21402
103437-103448
Abstract  |  PDF  |  Full Text  |  How to cite

The roles of ING5 expression in ovarian carcinogenesis and subsequent progression: a target of gene therapy

https://doi.org/10.18632/oncotarget.21968
103449-103464
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

IGF1R tyrosine kinase inhibitors and Vitamin K1 enhance the antitumor effects of Regorafenib in HCC cell lines

https://doi.org/10.18632/oncotarget.21403
103465-103476
Abstract  |  PDF  |  Full Text  |  How to cite

The association of triglycerides and total cholesterol concentrations with newly diagnosed diabetes in adults in China

https://doi.org/10.18632/oncotarget.21969
103477-103485
Abstract  |  PDF  |  Full Text  |  How to cite

Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycininduced pulmonary fibrosis in mice

https://doi.org/10.18632/oncotarget.21975
103486-103498
Abstract  |  PDF  |  Full Text  |  How to cite

The association of IL17A polymorphisms with IL17A serum levels and risk of ischemic stroke

https://doi.org/10.18632/oncotarget.21498
103499-103508
Abstract  |  PDF  |  Full Text  |  How to cite

Solanum incanum extract SRT100 induces melanoma cell apoptosis and inhibits established lung metastasis

https://doi.org/10.18632/oncotarget.21508
103509-103517
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Marital status and survival in patients with nonsmall cell lung cancer: an analysis of 70006 patients in the SEER database

https://doi.org/10.18632/oncotarget.21568
103518-103534
Abstract  |  PDF  |  Full Text  |  How to cite

A novel inflammationbased prognostic index for patients with esophageal squamous cell carcinoma: neutrophil lymphocyte ratio/albumin ratio

https://doi.org/10.18632/oncotarget.21989
103535-103542
Abstract  |  PDF  |  Full Text  |  How to cite

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer

https://doi.org/10.18632/oncotarget.21569
103543-103556
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

CXXC4 activates apoptosis through upregulating GDF15 in gastric cancer

https://doi.org/10.18632/oncotarget.21581
103557-103567
Abstract  |  PDF  |  Full Text  |  How to cite

STAT3mediated activation of miR21 is involved in downregulation of TIMP3 and neovascularization in the ischemic retina

https://doi.org/10.18632/oncotarget.21592
103568-103580
Abstract  |  PDF  |  Full Text  |  How to cite

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle

https://doi.org/10.18632/oncotarget.21658
103581-103600
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

IL22 promotes the progression of breast cancer through regulating HOXBAS5

https://doi.org/10.18632/oncotarget.22063
103601-103612
Abstract  |  PDF  |  Full Text  |  How to cite

Mitochondrial phosphoenolpyruvate carboxykinase PEPCKM regulates the cell metabolism of pancreatic neuroendocrine tumors pNET and desensitizes pNET to mTOR inhibitors

https://doi.org/10.18632/oncotarget.21665
103613-103625
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

ABR a novel inducer of transcription factor C/EBPα contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.22093
103626-103639
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Human induced pluripotent stem cellderived mesenchymal stem cells prevent adriamycin nephropathy in mice

https://doi.org/10.18632/oncotarget.21760
103640-103656
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells

https://doi.org/10.18632/oncotarget.21761
103657-103670
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer

https://doi.org/10.18632/oncotarget.22110
103671-103681
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The shedded ectodomain of Lyve1 expressed on M2like tumorassociated macrophages inhibits melanoma cell proliferation

https://doi.org/10.18632/oncotarget.21771
103682-103692
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Multiomics analyses of red blood cell reveal antioxidation mechanisms associated with hemolytic toxicity of gossypol

https://doi.org/10.18632/oncotarget.21779
103693-103709
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway

https://doi.org/10.18632/oncotarget.21780
103710-103730
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The polycomb group protein BMI1 inhibitor PTC209 is a potent antimyeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains

https://doi.org/10.18632/oncotarget.21909
103731-103743
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Membranebound fulllength Sonic Hedgehog identifies cancer stem cells in human nonsmall cell lung cancer

https://doi.org/10.18632/oncotarget.21781
103744-103757
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model

https://doi.org/10.18632/oncotarget.21911
103758-103774
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Fusion of the genes ataxin 2 like ATXN2L and Janus kinase 2 JAK2 in cutaneous CD4 positive Tcell lymphoma

https://doi.org/10.18632/oncotarget.21790
103775-103784
Abstract  |  PDF  |  Full Text  |  How to cite

SAMMSON drives the selfrenewal of liver tumor initiating cells through EZH2dependent Wnt/βcatenin activation

https://doi.org/10.18632/oncotarget.21792
103785-103796
Abstract  |  PDF  |  Full Text  |  How to cite

Ruxolitinib combined with vorinostat suppresses tumor growth and alters metabolic phenotype in hematological diseases

https://doi.org/10.18632/oncotarget.21951
103797-103814
Abstract  |  PDF  |  Full Text  |  How to cite

Dihydroartemisinin inhibits EMT induced by platinumbased drugs via Akt–Snail pathway

https://doi.org/10.18632/oncotarget.21793
103815-103827
Abstract  |  PDF  |  Full Text  |  How to cite

LINE1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells

https://doi.org/10.18632/oncotarget.21953
103828-103842
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Is there a difference in testosterone levels and its regulators in men carrying BRCA mutations

https://doi.org/10.18632/oncotarget.21802
103843-103850
Abstract  |  PDF  |  Full Text  |  How to cite

Interaction and joint effect of ALT and chronic liver disease on liver cancer in type 2 diabetes patients

https://doi.org/10.18632/oncotarget.21804
103851-103863
Abstract  |  PDF  |  Full Text  |  How to cite

Elevated serum urate is a potential factor in reduction of total bilirubin: a Mendelian randomization study

https://doi.org/10.18632/oncotarget.21977
103864-103873
Abstract  |  PDF  |  Full Text  |  How to cite

Metabolism pharmacokinetics and bioavailability of ZB716 a Steroidal Selective Estrogen Receptor Downregulator SERD

https://doi.org/10.18632/oncotarget.21808
103874-103889
Abstract  |  PDF  |  Full Text  |  How to cite

“Paradoxical” findings of tumor vascularity and oxygenation in recurrent glioblastomas refractory to bevacizumab

https://doi.org/10.18632/oncotarget.21978
103890-103899
Abstract  |  PDF  |  Full Text  |  How to cite

Autocrine hGH stimulates oncogenicity epithelialmesenchymal transition and cancer stem celllike behavior in human colorectal carcinoma

https://doi.org/10.18632/oncotarget.21812
103900-103918
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method

https://doi.org/10.18632/oncotarget.21865
103919-103930
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PARP inhibition causes premature loss of cohesion in cancer cells

https://doi.org/10.18632/oncotarget.21879
103931-103951
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

https://doi.org/10.18632/oncotarget.21895
103952-103967
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma

https://doi.org/10.18632/oncotarget.21916
103968-103974
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

LPINRLMF: lncRNAprotein interaction prediction by neighborhood regularized logistic matrix factorization

https://doi.org/10.18632/oncotarget.21934
103975-103984
Abstract  |  PDF  |  Full Text  |  How to cite

Cavin1 regulates caveolaemediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NFκB/Sp1 loop

https://doi.org/10.18632/oncotarget.21944
103985-103995
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Loss of digestive organ expansion factor Diexf reveals an essential role during murine embryonic development that is independent of p53

https://doi.org/10.18632/oncotarget.22087
103996-104006
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation

https://doi.org/10.18632/oncotarget.21945
104007-104021
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Overexpression of ceramide synthase 1 increases C18ceramide and leads to lethal autophagy in human glioma

https://doi.org/10.18632/oncotarget.21955
104022-104036
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Kv43 expression reverses ICa remodeling in ventricular myocytes of heart failure

https://doi.org/10.18632/oncotarget.21956
104037-104045
Abstract  |  PDF  |  Full Text  |  How to cite

Combination therapy with capecitabine and temozolomide in patients with low and high grade neuroendocrine tumors with an exploratory analysis of O6methylguanine DNA methyltransferase as a biomarker for response

https://doi.org/10.18632/oncotarget.22001
104046-104056
Abstract  |  PDF  |  Full Text  |  How to cite

Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore

https://doi.org/10.18632/oncotarget.22004
104057-104071
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The WAVE3YB1 interaction regulates cancer stem cells activity in breast cancer

https://doi.org/10.18632/oncotarget.22009
104072-104089
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo

https://doi.org/10.18632/oncotarget.22011
104090-104103
Abstract  |  PDF  |  Full Text  |  How to cite

Fasudil attenuates soluble fmslike tyrosine kinase1 sFlt1induced hypertension in pregnant mice through RhoA/ROCK pathway

https://doi.org/10.18632/oncotarget.22017
104104-104112
Abstract  |  PDF  |  Full Text  |  How to cite

Genomic variations in paired normal controls for lung adenocarcinomas

https://doi.org/10.18632/oncotarget.22020
104113-104122
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Pattern of p53 protein expression is predictive for survival in chemoradiotherapynaive esophageal adenocarcinoma

https://doi.org/10.18632/oncotarget.22021
104123-104135
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Cholesterol overload in the liver aggravates oxidative stressmediated DNA damage and accelerates hepatocarcinogenesis

https://doi.org/10.18632/oncotarget.22024
104136-104148
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Predictive value of quantitative HER2 HER3 and p95HER2 levels in HER2positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab

https://doi.org/10.18632/oncotarget.22027
104149-104159
Abstract  |  PDF  |  Full Text  |  How to cite

Long noncoding RNA ZFAS1 sponges miR486 to promote osteosarcoma cells progression and metastasis in vitro and vivo

https://doi.org/10.18632/oncotarget.22032
104160-104170
Abstract  |  PDF  |  Full Text  |  How to cite

Deletion of resistinlike moleculebeta attenuates angiotensin IIinduced abdominal aortic aneurysm

https://doi.org/10.18632/oncotarget.22042
104171-104181
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib LDE225 in men with highrisk localized prostate cancer undergoing prostatectomy

https://doi.org/10.18632/oncotarget.22115
104182-104192
Abstract  |  PDF  |  Full Text  |  How to cite

Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY9d in triplenegative breast cancer cells

https://doi.org/10.18632/oncotarget.22119
104193-104205
Abstract  |  PDF  |  Full Text  |  How to cite

Overexpression of miR216b sensitizes NSCLC cells to cisplatininduced apoptosis by targeting cJun

https://doi.org/10.18632/oncotarget.22171
104206-104215
Abstract  |  PDF  |  Full Text  |  How to cite

Glucosederived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade

https://doi.org/10.18632/oncotarget.22185
104216-104226
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Preoperative prediction of hepatocellular carcinoma with portal vein tumor thrombus based on conventional data

https://doi.org/10.18632/oncotarget.22198
104227-104237
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The significance of eosinophils in predicting the severity of acute ischemic stroke

https://doi.org/10.18632/oncotarget.22199
104238-104246
Abstract  |  PDF  |  Full Text  |  How to cite

Metformin reverses bFGFinduced epithelialmesenchymal transition in HCC cells

https://doi.org/10.18632/oncotarget.22200
104247-104257
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

https://doi.org/10.18632/oncotarget.22208
104258-104271
Abstract  |  PDF  |  Full Text  |  How to cite

A PiggyBac mediated approach for lactoferricin gene transfer in bovine mammary epithelial stem cells for management of bovine mastitis

https://doi.org/10.18632/oncotarget.22210
104272-104285
Abstract  |  PDF  |  Full Text  |  How to cite

GEJ cancers: gastric or esophageal tumors searching for the answer according to molecular identity

https://doi.org/10.18632/oncotarget.22216
104286-104294
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dynamic changes in the cell membrane on three dimensional low coherent quantitative phase microscopy 3D LCQPM after treatment with the near infrared photoimmunotherapy

https://doi.org/10.18632/oncotarget.22223
104295-104302
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Preclinical PET imaging of glycoprotein nonmetastatic melanoma B in triple negative breast cancer: feasibility of an antibodybased companion diagnostic agent

https://doi.org/10.18632/oncotarget.22228
104303-104314
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Hepatocellular glycogenotic foci after combined intraportal pancreatic islet transplantation and knockout of the carbohydrate responsive element binding protein in diabetic mice

https://doi.org/10.18632/oncotarget.22234
104315-104329
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1L expression in colorectal cancer liver metastasis in a cell contextdependent manner

https://doi.org/10.18632/oncotarget.22236
104330-104346
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Therapeutic effects of the euglenoid ichthyotoxin euglenophycin in colon cancer

https://doi.org/10.18632/oncotarget.22238
104347-104358
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inhibition of microRNA218 reduces HIF1α by targeting on Robo1 in mice aortic endothelial cells under intermittent hypoxia

https://doi.org/10.18632/oncotarget.22239
104359-104366
Abstract  |  PDF  |  Full Text  |  How to cite

Novel piplartinecontaining ruthenium complexes: synthesis cell growth inhibition apoptosis induction and ROS production on HCT116 cells

https://doi.org/10.18632/oncotarget.22248
104367-104392
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Predicting survival time of lung cancer patients using radiomic analysis

https://doi.org/10.18632/oncotarget.22251
104393-104407
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

ETS1 nucleolar and nonnucleolar TERT expression in nevus to melanoma progression

https://doi.org/10.18632/oncotarget.22254
104408-104417
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Human glioma stemlike cells induce malignant transformation of bone marrow mesenchymal stem cells by activating TERT expression

https://doi.org/10.18632/oncotarget.22301
104418-104429
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High frequency of radiological differential responses with polyADPRibose polymerase PARP inhibitor therapy

https://doi.org/10.18632/oncotarget.22303
104430-104443
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Radiomic analysis in contrastenhanced CT: predict treatment response to chemoradiotherapy in esophageal carcinoma

https://doi.org/10.18632/oncotarget.22304
104444-104454
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The fate of murine double minute X MdmX is dictated by distinct signaling pathways through murine double minute 2 Mdm2

https://doi.org/10.18632/oncotarget.22320
104455-104466
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Prognostic impact of multimorbidity in patients with type 2 diabetes and STelevation myocardial infarction

https://doi.org/10.18632/oncotarget.22324
104467-104477
Abstract  |  PDF  |  Full Text  |  How to cite

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3phosphoglycerate dehydrogenase PHGDH

https://doi.org/10.18632/oncotarget.22327
104478-104491
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Neuroprotective effects of allicin on ischemiareperfusion brain injury

https://doi.org/10.18632/oncotarget.22355
104492-104507
Abstract  |  PDF  |  Full Text  |  How to cite

hsamiR29c3p regulates biological function of colorectal cancer by targeting SPARC

https://doi.org/10.18632/oncotarget.22356
104508-104524
Abstract  |  PDF  |  Full Text  |  How to cite

Human CRL4DDB2 ubiquitin ligase preferentially regulates postrepair chromatin restoration of H3K56Ac through recruitment of histone chaperon CAF1

https://doi.org/10.18632/oncotarget.21869
104525-104542
Abstract  |  PDF  |  Full Text  |  How to cite

Meta-Analysis

The microRNA miR10b as a potentially promising biomarker to predict the prognosis of cancer patients: a metaanalysis

https://doi.org/10.18632/oncotarget.21428
104543-104551
Abstract  |  PDF  |  Full Text  |  How to cite

Clinical Research Papers

Multicenter phase II study of apatinib treatment for metastatic gastric cancer after failure of secondline chemotherapy

https://doi.org/10.18632/oncotarget.21053
104552-104559
Abstract  |  PDF  |  Full Text  |  How to cite

Restingstate functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment

https://doi.org/10.18632/oncotarget.21282
104560-104570
Abstract  |  PDF  |  Full Text  |  How to cite

Comparison of repeated surgical resection and radiofrequency ablation for small recurrent hepatocellular carcinoma after primary resection

https://doi.org/10.18632/oncotarget.21604
104571-104581
Abstract  |  PDF  |  Full Text  |  How to cite

Sex differences in outcomes and risk factors among elderly patients with ischemic stroke

https://doi.org/10.18632/oncotarget.21967
104582-104593
Abstract  |  PDF  |  Full Text  |  How to cite

Effect of postoperative analgesia technique on the prognosis of gastric cancer: a retrospective analysis

https://doi.org/10.18632/oncotarget.21979
104594-104604
Abstract  |  PDF  |  Full Text  |  How to cite

Improved glycemic control with proximal intestinal bypass and weight loss following gastrectomy in nonobese diabetic gastric cancer patients

https://doi.org/10.18632/oncotarget.22262
104605-104614
Abstract  |  PDF  |  Full Text  |  How to cite

Reviews

Exploiting cancer's phenotypic guise against itself: targeting ectopically expressed peptide Gprotein coupled receptors for lung cancer therapy

https://doi.org/10.18632/oncotarget.18403
104615-104637
Abstract  |  PDF  |  Full Text  |  How to cite

Current diagnostics and treatment of fibrosarcoma –perspectives for future therapeutic targets and strategies

https://doi.org/10.18632/oncotarget.20136
104638-104653
Abstract  |  PDF  |  Full Text  |  How to cite

Testicular cancer from diagnosis to epigenetic factors

https://doi.org/10.18632/oncotarget.20992
104654-104663
Abstract  |  PDF  |  Full Text  |  How to cite

Advances in the understanding and management of Tcell prolymphocytic leukemia

https://doi.org/10.18632/oncotarget.22272
104664-104686
Abstract  |  PDF  |  Full Text  |  How to cite

Tumorderived exosomes in ovarian cancer – liquid biopsies for early detection and realtime monitoring of cancer progression

https://doi.org/10.18632/oncotarget.22191
104687-104703
Abstract  |  PDF  |  Full Text  |  How to cite


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