Oncotarget

Research Papers:

Treatment and survival outcomes of lobular carcinoma in situ of the breast: a SEER population based study

Pu Cheng, Qi Huang, Jiafeng Shou, Guoming Hu, Mengjiao Han and Jian Huang _

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Oncotarget. 2017; 8:103047-103054. https://doi.org/10.18632/oncotarget.21461

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Abstract

Pu Cheng1,*, Qi Huang1,*, Jiafeng Shou1,*, Guoming Hu2, Mengjiao Han3 and Jian Huang1,4

1Department of Surgical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Department of General Surgery (Breast and Thyroid Surgery), Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Zhejiang, China

3Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw hospital, Medical School of Zhejiang University, Hangzhou, China

4Gastroenterology Institute, Zhejiang University School of Medicine, Hangzhou, China

*These authors contributed equally to this work

Correspondence to:

Jian Huang, email: drhuangjian@zju.edu.cn

Keywords: lobular carcinoma in situ, overall survival, lumpectomy, mastectomy, SEER

Received: July 20, 2017     Accepted: September 18, 2017     Published: October 03, 2017

ABSTRACT

Lobular carcinoma in situ (LCIS) represents 5.3% of in situ specimens, and is thought to carry a low risk for developing to the invasive lobular breast cancer (ILC). There is still no standard care approach for patients with LCIS. We aimed to define the impacts of surgical and radiation intervention on survival outcomes of LCIS. LCIS cases from 2004 to 2013 of the recent Surveillance, Epidemiology, and End Results (SEER) database were analyzed. Clinicopathologic features were analyzed in 16002 patients between 2004 and 2013. Treatment modalities included no surgery (NS), lumpectomy alone (LA), lumpectomy with radiation treatment (LRT), mastectomy alone (MA) and mastectomy with radiation treatment (MRT). The overall survival (OS) was calculated by the Kaplan-Meier method. Univariate and multivariate analyses were performed using the variables of treatment, race, hormone receptor status, grade and age. Among 16002 patients, median follow-up was 54 months. Patients treated with LA had superior OS for NS (P = 0.001), MA (P < 0.001) and MRT P = 0.018). LRT only had superior OS for MRT (P = 0.009). There was no statistically significance between LA and LRT (P = 0.317). Improved OS was also correlated with younger age (P < 0.001), progesterone receptor positive (P = 0.001). Black patients had the worst OS (P < 0.001). There was no obvious survival difference among grade groups (P = 0.536). The LCIS patients treated with LA or LRT had better survival comparing with other groups. Considering the medical expense and the risk of radiotherapy, LA may be the most appropriate therapy for patients with LCIS.


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