Current diagnostics and treatment of fibrosarcoma –perspectives for future therapeutic targets and strategies
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Daniela Augsburger1, Peter J. Nelson2, Thomas Kalinski3, Andrej Udelnow1, Thomas Knösel4, Monika Hofstetter2, Ji Wei Qin1, Yan Wang1, Arvid Sen Gupta1, Susanne Bonifatius1, Minglun Li5, Christiane J. Bruns1,6,7 and Yue Zhao1,6,7
1Department of General, Visceral und Vascular Surgery, Otto-von-Guericke University, Magdeburg, Germany
2Clinical Biochemistry Group, Medizinische Klinik und Poliklinik IV, University of Munich, Munich, Germany
3Department of Pathology, Otto-von-Guericke University, Magdeburg, Germany
4Institute of Pathology, Ludwig-Maximilians-University (LMU), Munich, Germany
5Department of Radiation Oncology, Ludwig-Maximilians-University (LMU), Munich, Germany
6Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany
7Present address: Department of General, Visceral and Cancer Surgery, University Hospital of Cologne, Cologne, Germany
Christiane J. Bruns, email: [email protected]
Yue Zhao, email: [email protected]
Keywords: fibrosarcoma, tumor microenvironment, therapeutic resistance, matrix metalloproteinases (MMPs)
Received: June 06, 2017 Accepted: July 29, 2017 Published: August 10, 2017
Adult-type fibrosarcoma is a rare and highly aggressive subtype of soft tissue sarcomas. Due to the existence of other spindle-cell shaped sarcomas, its diagnosis is always one of exclusion. The likelihood of misdiagnoses between similar tumour entities is high, and often leads to inappropriate tumour treatment. We summarize here the main features of fibrosarcoma. When fibrosarcoma is appropriately diagnosed, the patient`s overall prognosis is generally quite poor. Fibrosarcoma is characterized by its low sensitivity towards radio- and chemotherapy as well as by its high rate of tumour recurrences. Thus it is important to identify new methods to improve treatment of this tumour entity. We discuss some promising new directions in fibrosarcoma research, specifically focusing on more effective targeting of the tumour microenvironment. Communication between tumour cells and their surrounding stromal tissue play a crucial role in cancer progression, invasion, metastasis and chemosensitivity. The therapeutic potential of targeting the tumour microenvironment is addressed.
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