Evaluation of the association of UBASH3A and SYNGR1 with rheumatoid arthritis and disease activity and severity in Han Chinese
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Dan Liu1,*, Jiayu Liu1,*, Guofeng Cui2, Haojie Yang3, Tuanping Cao1 and Li Wang1
1Departement of Rheumatology and Immunology, Xi'an No.5 Hospital, Xi'an, Shaanxi, China
2Department of Orthopedics, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China
3Department of Prevention and Health Care, Xi’an Jiaotong University Hospital, Xi’an, Shaanxi, China
*These authors contributed equally to this work and joint first authors
Dan Liu, email: [email protected]
Keywords: rheumatoid arthritis susceptibility, common variants, UBASH3A, SYNGR1, disease activity and severity
Received: September 13, 2017 Accepted: October 03, 2017 Published: October 17, 2017
Rheumatoid arthritis (RA) is a common complex autoimmune disorder. UBASH3A and SYNGR1 were identified recently as susceptibility genes for RA risk in Korean and European populations, but the genetic aetiology and pathogenesis of RA have not been fully elucidated. We designed a two-stage case-control study including 916 RA patients and 2,266 unrelated healthy controls to identify common genetic variants in UBASH3A and SYNGR1 that predispose Han Chinese individuals to RA. We also evaluated the role of associated variants in clinical manifestations of RA, which may provide clues to the mechanisms involved in the aetiology of RA. We successfully identified two SNPs, rs1893592 in UBASH3A and rs909685 in SYNGR1, as significantly associated with the disease status of RA using our two-stage strategy. The rs1893592 SNP in UBASH3A was related with DAS28, CRP level and bone erosion. In summary, our results indicate that genetic variants in UBASH3A and SYNGR1 may modify individual susceptibility to RA in the Han Chinese population and support the role of the UBASH3A gene in RA disease activity and severity.
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