The microRNA miR-10b as a potentially promising biomarker to predict the prognosis of cancer patients: a meta-analysis
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Yi Zhang1,*, Rong-Bo Liao2,*, Li-Lin Hu3, Bi-Xia Tong4, Teng-Fei Hao2 and Hua-Jun Wu2
1Department of General Surgery, The First People’s Hospital of Neijiang, Neijiang 641000, Sichuan Province, P.R. China
2Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, P.R. China
3Department of Medicine, Nanchang University, Nanchang 330000, Jiangxi Province, P.R. China
4Department of Nursing, Shangrao People’s Hospital, Shangrao 334000, Jiangxi Province, P.R. China
*These two authors contributed equally to this work
Hua-Jun Wu, email: [email protected]
Keywords: miR-10b, carcinoma, metastasis, meta-analysis
Received: April 21, 2017 Accepted: August 17, 2017 Published: September 30, 2017
Background: Reported studies on carcinoma have evaluated the significance of the microRNA miR-10b in the development and progression of many cancers. Increased expression of miR-10b is associated with the susceptibility to lymph node metastasis and distant metastasis in various tumors.
Results: The results of the meta-analysis revealed that lymph node metastasis occurred more frequently in the patients group with high expression level of miR-10b than in the patients group with low expression level of miR-10b (OR=4.65, 95% CI: 3.40–6.37, P <0.00001, fixed-effects model). Additionally, a similar result was observed in the association between miR-10b expression and distant metastasis (OR=2.70, 95% CI: 1.79–4.08, P <0.00001, fixed-effects model).
Materials and Methods: In this study, a meta-analysis, including the majority of the relevant articles, was conducted to investigate the association of the miR-10b expression level with metastasis in cancer patients. Systematic literature retrieval was performed by searching in a number of electronic databases. The meta-analysis was conducted using the RevMan 5.2 software and Stata SE12.0 software. A total of 962 patients with carcinoma from 9 studies were included in analysis.
Conclusions: This meta-analysis demonstrated that the overexpression of miR-10b was significantly correlated with metastasis status, and indicated the potential clinical use of miR-10b as a molecular biomarker, particularly in assessing prognosis for patients with cancers.
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