Research Papers:

Predicting survival time of lung cancer patients using radiomic analysis

Ahmad Chaddad _, Christian Desrosiers, Matthew Toews and Bassam Abdulkarim

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Oncotarget. 2017; 8:104393-104407. https://doi.org/10.18632/oncotarget.22251

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Ahmad Chaddad1,2, Christian Desrosiers2, Matthew Toews2 and Bassam Abdulkarim1

1Division of Radiation Oncology, McGill University, Montréal, Canada

2The Laboratory for Imagery, Vision and Artificial Intelligence, Ecole de Technologie Supérieure, Montréal, Canada

Correspondence to:

Ahmad Chaddad, email: [email protected]

Keywords: lung cancer; NSCLC; cancer staging; radiomics; texture features

Received: May 30, 2017    Accepted: October 02, 2017    Published: November 01, 2017


Objectives: This study investigates the prediction of Non-small cell lung cancer (NSCLC) patient survival outcomes based on radiomic texture and shape features automatically extracted from tumor image data.

Materials and Methods: Retrospective analysis involves CT scans of 315 NSCLC patients from The Cancer Imaging Archive (TCIA). A total of 24 image features are computed from labeled tumor volumes of patients within groups defined using NSCLC subtype and TNM staging information. Spearman’s rank correlation, Kaplan-Meier estimation and log-rank tests were used to identify features related to long/short NSCLC patient survival groups. Automatic random forest classification was used to predict patient survival group from multivariate feature data. Significance is assessed at P < 0.05 following Holm-Bonferroni correction for multiple comparisons.

Results: Significant correlations between radiomic features and survival were observed for four clinical groups: (group, [absolute correlation range]): (large cell carcinoma (LCC) [0.35, 0.43]), (tumor size T2, [0.31, 0.39]), (non lymph node metastasis N0, [0.3, 0.33]), (TNM stage I, [0.39, 0.48]). Significant log-rank relationships between features and survival time were observed for three clinical groups: (group, hazard ratio): (LCC, 3.0), (LCC, 3.9), (T2, 2.5) and (stage I, 2.9). Automatic survival prediction performance (i.e. below/above median) is superior for combined radiomic features with age-TNM in comparison to standard TNM clinical staging information (clinical group, mean area-under-the-ROC-curve (AUC)): (LCC, 75.73%), (N0, 70.33%), (T2, 70.28%) and (TNM-I, 76.17%).

Conclusion: Quantitative lung CT imaging features can be used as indicators of survival, in particular for patients with large-cell-carcinoma (LCC), primary-tumor-sizes (T2) and no lymph-node-metastasis (N0).

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