Research Papers:

The association of triglycerides and total cholesterol concentrations with newly diagnosed diabetes in adults in China

Jing Cui, Jianping Sun, Wei Wang, Hualei Xin, Qing Qiao, Zulqarnain Baloch and Aiguo Ma _

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Oncotarget. 2017; 8:103477-103485. https://doi.org/10.18632/oncotarget.21969

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Jing Cui1,2,3,*, Jianping Sun1,2,3,*, Wei Wang1,5, Hualei Xin2,3, Qing Qiao6, Zulqarnain Baloch4,* and Aiguo Ma1,*

1Department of Nutrition and Food Hygiene, Medical College of Qingdao University, Qingdao, China

2Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China

3Qingdao Institute of Preventive Medicine, Qingdao, China

4College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

5Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing, China

6Department of Public Health, University of Helsinki, Helsinki, Finland

*These authors contributed equally to this work

Correspondence to:

Aiguo Ma, email: [email protected]

Zulqarnain Baloch, email: [email protected]

Keywords: triglycerides, total cholesterol, newly diagnosed, adult onset diabetes, waist circumference

Received: July 29, 2017     Accepted: September 22, 2017     Published: October 19, 2017


Background: It has already been suggested that high abnormal blood lipid concentration is associated with hyperglycaemia. However, no data is available about the roles of triglycerides (TG) and total cholesterol (TC) levels in diabetes. Here, for the first time we investigated the roles of TG and TC levels, gender and abdominal fat in the development of newly diagnosed diabetes in China.

Materials and Methods: Two population-based cross-sectional surveys were conducted from 2006 to 2009 in Qingdao, China. Newly diagnosed diabetes was defined according to FPG and/or 2 h PG criteria. The associations between diabetes and TG, and TC levels were assessed by multi-variable logistic regression models.

Results: As compared with non-diabetes, the odds ratio[(95% confidence intervals), OR(95% CI)] for diabetes corresponding to hypertriglyceridemia (HTG) were 1.54 (1.01, 2.35) in men and 2.02 (1.49, 3.10) in women for TG and accompany with Hypercholesterolemia (HTC) 2.93 (1.97, 4.37) and 2.13 (1.49, 3.05) for TC, when both were fitted simultaneously in the model adjusting for age, geographic division, marital status, school years, family history of diabetes, monthly income, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), high density lipoprotein cholesterol (HDL-C), alanine amino transferase (ALT) and gamma-glutamyltransferase (GGT).

Conclusions: HTG in both gender, borderline high TC and HTC in men were an independent risk factor for diabetes in this Chinese population, however, HTC was mediated through abdominal fat for diabetes in women. Our findings may help to enhance the current knowledge of diabetes patho-physiology, and the associations between TG, TC level and diabetes is also clinically informative.

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