LincRNA FEZF1-AS1 contributes to the proliferation of LAD cells by silencing p57 expression
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Shuai Jin1, Siyu Chen1, Yongfu Ma1, Bo Yang1 and Yang Liu1
1Department of Thoracic surgery, PLA General Hospital, Beijing, 100853 China
Yang Liu, email: [email protected]
Keywords: lung adenocarcinoma, FEZF1-AS1, LSD1, EZH2, H3K4me2
Received: May 23, 2017 Accepted: September 05, 2017 Published: September 23, 2017
LincRNA FEZF1-AS1 has been identified to exert oncogenic functions in various biological processes of tumorigenesis. However, the function of FEZF1-AS1 in lung adenocarcinoma still remains unclear. Our findings revealed that FEZF1-AS1 was increased in lung adenocarcinoma tissues and cell lines and high level of FEZF1-AS1 was associated with poor prognosis of lung adenocarcinoma. Functional experiments and mechanistic investigations demonstrated that knockdown of FEZF1-AS1 significantly repressed proliferation through influencing the distribution of cell cycle. Besides, we also uncovered that FEZF1-AS1 could suppress p57 expression through recruiting EZH2 and LSD1 to the promoter of p57, thus influenced the cell cycle and proliferation. Collectively, our results suggested that FEZF1-AS1 was involved in the progression of lung adenocarcinoma and might be as a potential therapy target for human lung adenocarcinoma.
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