Oncotarget

VOLUME 6 (2015)

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About The Cover

The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization. See Zhou et al.

Table of Contents

Editorial

Viral infection at the endothelium

https://doi.org/10.18632/oncotarget.5246
26541-26542
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LG24 and sex chromosomes

https://doi.org/10.18632/oncotarget.5250
26543-26543
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Targeting glutaminase and mTOR

https://doi.org/10.18632/oncotarget.5263
26544-26545
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Insight into miRNA biogenesis with RNA sequencing

https://doi.org/10.18632/oncotarget.5264
26546-26547
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LMOD3: the “missing link” in nemaline myopathy

https://doi.org/10.18632/oncotarget.5267
26548-26549
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Pharmacological manipulation of AID

https://doi.org/10.18632/oncotarget.5269
26550-26551
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NKT10 cells: a novel iNKT cell subset

https://doi.org/10.18632/oncotarget.5270
26552-26553
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Regulation of extrathymic Treg cell conversion by CD5

https://doi.org/10.18632/oncotarget.5809
26554-26555
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Editorial: Chromosome

In vivo selection of novel biotherapeutics

https://doi.org/10.18632/oncotarget.5247
26556-26557
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RECQL: a DNA helicase in breast cancer

https://doi.org/10.18632/oncotarget.5452
26558-26559
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Research Perspectives

Triple negative breast cancer: looking for the missing link between biology and treatments

https://doi.org/10.18632/oncotarget.5306
26560-26574
Abstract  |  PDF  |  Full Text  |  How to cite

Targeting Batf2 for infectious diseases and cancer

https://doi.org/10.18632/oncotarget.5576
26575-26582
Abstract  |  PDF  |  Full Text  |  How to cite

Priority Research Papers

Involvement of p53 in insulinlike growth factor binding protein3 regulation in the breast cancer cell response to DNA damage

https://doi.org/10.18632/oncotarget.5612
26583-26598
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The oncolytic peptide LTX315 kills cancer cells through Bax/Bakregulated mitochondrial membrane permeabilization

https://doi.org/10.18632/oncotarget.5613
26599-26614
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Radiationinduced lung damage promotes breast cancer lungmetastasis through CXCR4 signaling

https://doi.org/10.18632/oncotarget.5666
26615-26632
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas

https://doi.org/10.18632/oncotarget.5782
26633-26650
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

https://doi.org/10.18632/oncotarget.5791
26651-26662
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Gerotarget (Focus on Aging)

APOEbysex interactions on brain structure and metabolism in healthy elderly controls

https://doi.org/10.18632/oncotarget.5185
26663-26674
Abstract  |  PDF  |  Full Text  |  How to cite

Reciprocal regulation between sirtuin1 and angiotensinII in the substantia nigra: implications for aging and neurodegeneration

https://doi.org/10.18632/oncotarget.5596
26675-26689
Abstract  |  PDF  |  Full Text  |  How to cite

To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss

https://doi.org/10.18632/oncotarget.5614
26690-26701
Abstract  |  PDF  |  Full Text  |  How to cite

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from longlived GHRKO mice

https://doi.org/10.18632/oncotarget.5760
26702-26715
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Serotonin 6 receptor controls alzheimer’s disease and depression

https://doi.org/10.18632/oncotarget.5777
26716-26728
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Pathology

Genomewide analysis of DNA methylation and gene expression patterns in purified uncultured human liver cells and activated hepatic stellate cells

https://doi.org/10.18632/oncotarget.4925
26729-26745
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer

https://doi.org/10.18632/oncotarget.4818
26746-26756
Abstract  |  PDF  |  Full Text  |  How to cite

A network metaanalysis of the efficacy and side effects of udcabased therapies for primary sclerosing cholangitis

https://doi.org/10.18632/oncotarget.5610
26757-26769
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

TGFß isoforms in cancer: Immunohistochemical expression and Smadpathwayactivityanalysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity

https://doi.org/10.18632/oncotarget.5780
26770-26781
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Liver enzymes and metabolic syndrome: a largescale casecontrol study

https://doi.org/10.18632/oncotarget.5792
26782-26788
Abstract  |  PDF  |  Full Text  |  How to cite

Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression

https://doi.org/10.18632/oncotarget.4628
26789-26803
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Neuroscience

Characterizing PCDH19 in human induced pluripotent stem cells iPSCs and iPSCderived developing neurons: emerging role of a protein involved in controlling polarity during neurogenesis

https://doi.org/10.18632/oncotarget.5757
26804-26813
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Reviews

A decade of EGFR inhibition in EGFRmutated non small cell lung cancer NSCLC: Old successes and future perspectives

https://doi.org/10.18632/oncotarget.4254
26814-26825
Abstract  |  PDF  |  Full Text  |  How to cite

Notch signaling deregulation in multiple myeloma: A rational molecular target

https://doi.org/10.18632/oncotarget.5025
26826-26840
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers

Resistance to anticancer vaccination effect is controlled by a cancer cellautonomous phenotype that disrupts immunogenic phagocytic removal

https://doi.org/10.18632/oncotarget.4754
26841-26860
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nanoparticleinduced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

https://doi.org/10.18632/oncotarget.4766
26861-26875
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to Xray radiation

https://doi.org/10.18632/oncotarget.4946
26876-26885
Abstract  |  PDF  |  Full Text  |  How to cite

BRAF mutation testing with a rapid fully integrated molecular diagnostics system

https://doi.org/10.18632/oncotarget.4723
26886-26894
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A novel smallmolecule IAP antagonist AZD5582 draws Mcl1 downregulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer

https://doi.org/10.18632/oncotarget.4822
26895-26908
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Genomewide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

https://doi.org/10.18632/oncotarget.4817
26909-26921
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dexamethasoneinduced cell death is restricted to specific molecular subgroups of multiple myeloma

https://doi.org/10.18632/oncotarget.4616
26922-26934
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Deregulation of ARID1A CDH1 cMET and PIK3CA and targetrelated microRNA expression in gastric cancer

https://doi.org/10.18632/oncotarget.4775
26935-26945
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.4521
26946-26959
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells

https://doi.org/10.18632/oncotarget.4745
26960-26970
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Exosomal levels of miRNA21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients

https://doi.org/10.18632/oncotarget.4699
26971-26981
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Carfilzomib enhances natural killer cellmediated lysis of myeloma linked with decreasing expression of HLA class I

https://doi.org/10.18632/oncotarget.4831
26982-26994
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

DNA double strand break repair defect and sensitivity to poly ADPribose polymerase PARP inhibition in human papillomavirus 16positive head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.4863
26995-27007
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloidderived suppressor cells in breast cancer

https://doi.org/10.18632/oncotarget.4714
27008-27022
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

https://doi.org/10.18632/oncotarget.4809
27023-27036
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Ckit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model

https://doi.org/10.18632/oncotarget.4815
27037-27048
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells

https://doi.org/10.18632/oncotarget.4819
27049-27064
Abstract  |  PDF  |  Full Text  |  How to cite

Integrative transcriptomicsbased identification of cryptic drivers of taxolresistance genes in ovarian carcinoma cells: Analysis of the androgen receptor

https://doi.org/10.18632/oncotarget.4824
27065-27082
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The ZEB1/miR200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

https://doi.org/10.18632/oncotarget.4807
27083-27096
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

AKT3 promotes prostate cancer proliferation cells through regulation of Akt BRaf & TSC1/TSC2

https://doi.org/10.18632/oncotarget.4553
27097-27112
Abstract  |  PDF  |  Full Text  |  How to cite

SIRT1 in B[a]Pinduced lung tumorigenesis

https://doi.org/10.18632/oncotarget.4729
27113-27129
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth

https://doi.org/10.18632/oncotarget.4825
27130-27145
Abstract  |  PDF  |  Full Text  |  How to cite

IWR1 inhibits epithelialmesenchymal transition of colorectal cancer cells through suppressing Wnt/βcatenin signaling as well as survivin expression

https://doi.org/10.18632/oncotarget.4354
27146-27159
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A core of kinaseregulated interactomes defines the neoplastic MDSC lineage

https://doi.org/10.18632/oncotarget.4746
27160-27175
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population

https://doi.org/10.18632/oncotarget.4870
27176-27186
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

By inhibiting Ras/Raf/ERK and MMP9 knockdown of EpCAM inhibits breast cancer cell growth and metastasis

https://doi.org/10.18632/oncotarget.4551
27187-27198
Abstract  |  PDF  |  Full Text  |  How to cite

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer

https://doi.org/10.18632/oncotarget.4508
27199-27213
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR17 family in prostate cancer

https://doi.org/10.18632/oncotarget.4877
27214-27226
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Combinatorial highthroughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs

https://doi.org/10.18632/oncotarget.4507
27227-27238
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Talin1 targeting potentiates antiangiogenic therapy by attenuating invasion and stemlike features of glioblastoma multiforme

https://doi.org/10.18632/oncotarget.4835
27239-27251
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

https://doi.org/10.18632/oncotarget.4583
27252-27266
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Chinese family with familial adenomatous coli

https://doi.org/10.18632/oncotarget.4776
27267-27274
Abstract  |  PDF  |  Full Text  |  How to cite

Low doses of Xrays induce prolonged and ATMindependent persistence of γH2AX foci in human gingival mesenchymal stem cells

https://doi.org/10.18632/oncotarget.4739
27275-27287
Abstract  |  PDF  |  Full Text  |  How to cite

Spherederived tumor cells exhibit impaired metastasis by a hostmediated quiescent phenotype

https://doi.org/10.18632/oncotarget.4803
27288-27303
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Detection and enumeration of circulating tumor cells based on their invasive property

https://doi.org/10.18632/oncotarget.4454
27304-27311
Abstract  |  PDF  |  Full Text  |  How to cite

Targeting the mRNAbinding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells

https://doi.org/10.18632/oncotarget.4743
27312-27331
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma

https://doi.org/10.18632/oncotarget.2903
27332-27342
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inhibition of miR21 restores RANKL/OPG ratio in multiple myelomaderived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

https://doi.org/10.18632/oncotarget.4398
27343-27358
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

LAG3 and PD1 coinhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

https://doi.org/10.18632/oncotarget.4751
27359-27377
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients

https://doi.org/10.18632/oncotarget.4860
27378-27387
Abstract  |  PDF  |  Full Text  |  How to cite

A synthetic peptide targeting the BH4 domain of Bcl2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3binding pocket of Bcl2

https://doi.org/10.18632/oncotarget.4489
27388-27402
Abstract  |  PDF  |  Full Text  |  How to cite

Suppression of βcatenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

https://doi.org/10.18632/oncotarget.4741
27403-27415
Abstract  |  PDF  |  Full Text  |  How to cite

SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.4862
27416-27426
Abstract  |  PDF  |  Full Text  |  How to cite

The positive feedback between Snail and DAB2IP regulates EMT invasion and metastasis in colorectal cancer

https://doi.org/10.18632/oncotarget.4861
27427-27439
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Galeterone and VNPT55 induce proteasomal degradation of AR/ARV7 induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo

https://doi.org/10.18632/oncotarget.4578
27440-27460
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

STAT3 pathway regulates lungderived brain metastasis initiating cell capacity through miR21 activation

https://doi.org/10.18632/oncotarget.4742
27461-27477
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Myeloidderived suppressor cells contribute to A2B adenosine receptorinduced VEGF production and angiogenesis in a mouse melanoma model

https://doi.org/10.18632/oncotarget.4393
27478-27489
Abstract  |  PDF  |  Full Text  |  How to cite

Inhibition of polyADPribose polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene

https://doi.org/10.18632/oncotarget.4748
27490-27504
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nuclear estrogen receptorα expression is an independent predictor of recurrence in male patients with pT1aN0 lung adenocarcinomas and correlates with regulatory Tcell infiltration

https://doi.org/10.18632/oncotarget.4752
27505-27518
Abstract  |  PDF  |  Full Text  |  How to cite

Depletion of the cisplatin targeted HMGBbox factor UBF selectively induces p53independent apoptotic death in transformed cells

https://doi.org/10.18632/oncotarget.4823
27519-27536
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dequalinium blocks macrophageinduced metastasis following local radiation

https://doi.org/10.18632/oncotarget.4826
27537-27554
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Infiltrating bone marrow mesenchymal stem cells BMMSCs increase prostate cancer cell invasion via altering the CCL5/HIF2α/androgen receptor signals

https://doi.org/10.18632/oncotarget.4515
27555-27565
Abstract  |  PDF  |  Full Text  |  How to cite

Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy

https://doi.org/10.18632/oncotarget.4491
27566-27579
Abstract  |  PDF  |  Full Text  |  How to cite

Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1

https://doi.org/10.18632/oncotarget.4768
27580-27595
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts Stichoposide D inhibits growth of leukemia xenografts

https://doi.org/10.18632/oncotarget.4820
27596-27612
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression

https://doi.org/10.18632/oncotarget.4546
27613-27627
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Zinc finger transcription factor CASZ1 interacts with histones DNA repair proteins and recruits NuRD complex to regulate gene transcription

https://doi.org/10.18632/oncotarget.4733
27628-27640
Abstract  |  PDF  |  Full Text  |  How to cite

NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer

https://doi.org/10.18632/oncotarget.4737
27641-27650
Abstract  |  PDF  |  Full Text  |  How to cite

IL6 signaling contributes to cisplatin resistance in nonsmall cell lung cancer via the upregulation of antiapoptotic and DNA repair associated molecules

https://doi.org/10.18632/oncotarget.4753
27651-27660
Abstract  |  PDF  |  Full Text  |  How to cite

Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells

https://doi.org/10.18632/oncotarget.4871
27661-27673
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Mutation of the BRCA1 SQcluster results in aberrant mitosis reduced homologous recombination and a compensatory increase in nonhomologous end joining

https://doi.org/10.18632/oncotarget.4876
27674-27687
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer

https://doi.org/10.18632/oncotarget.4280
27688-27699
Abstract  |  PDF  |  Full Text  |  How to cite

Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis

https://doi.org/10.18632/oncotarget.4392
27700-27713
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Target therapy of multiple myeloma by PTXNPs and ABCG2 antibody in a mouse xenograft model

https://doi.org/10.18632/oncotarget.4663
27714-27724
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma

https://doi.org/10.18632/oncotarget.4834
27725-27735
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MicroRNA424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4811
27736-27750
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4

https://doi.org/10.18632/oncotarget.4859
27751-27762
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NefM1 a peptide antagonist of CXCR4 inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers

https://doi.org/10.18632/oncotarget.4615
27763-27777
Abstract  |  PDF  |  Full Text  |  How to cite

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGFβ pathways

https://doi.org/10.18632/oncotarget.4813
27778-27793
Abstract  |  PDF  |  Full Text  |  How to cite

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIMmediated degradation of stathmin1

https://doi.org/10.18632/oncotarget.4533
27794-27804
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MiR6253p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells

https://doi.org/10.18632/oncotarget.4738
27805-27815
Abstract  |  PDF  |  Full Text  |  How to cite

Rituximabinduced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large Bcell lymphoma

https://doi.org/10.18632/oncotarget.4816
27816-27831
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Vaccineinduced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site

https://doi.org/10.18632/oncotarget.4940
27832-27846
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2

https://doi.org/10.18632/oncotarget.4443
27847-27864
Abstract  |  PDF  |  Full Text  |  How to cite

Immunoprofile from tissue microarrays to stratify familial breast cancer patients

https://doi.org/10.18632/oncotarget.4720
27865-27879
Abstract  |  PDF  |  Full Text  |  How to cite

A novel mitosisassociated lncRNA MAlinc1 is required for cell cycle progression and sensitizes cancer cells to Paclitaxel

https://doi.org/10.18632/oncotarget.4944
27880-27890
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

USP35 activated by miR let7a inhibits cell proliferation and NFκB activation through stabilization of ABIN2

https://doi.org/10.18632/oncotarget.4451
27891-27906
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting SOD1 induces synthetic lethal killing in BLM and CHEK2deficient colorectal cancer cells

https://doi.org/10.18632/oncotarget.4875
27907-27922
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Antitumor activity of the novel multikinase inhibitor EC70124 in triple negative breast cancer

https://doi.org/10.18632/oncotarget.4736
27923-27937
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Automated tumor analysis for molecular profiling in lung cancer

https://doi.org/10.18632/oncotarget.4391
27938-27952
Abstract  |  PDF  |  Full Text  |  How to cite

Growth arrest DNA damageinducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4446
27953-27965
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer

https://doi.org/10.18632/oncotarget.4626
27966-27979
Abstract  |  PDF  |  Full Text  |  How to cite

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines

https://doi.org/10.18632/oncotarget.4735
27980-28000
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair

https://doi.org/10.18632/oncotarget.4830
28001-28010
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

https://doi.org/10.18632/oncotarget.4377
28011-28025
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

COP9 signalosome subunit 6 CSN6 regulates E6AP/UBE3A in cervical cancer

https://doi.org/10.18632/oncotarget.4731
28026-28041
Abstract  |  PDF  |  Full Text  |  How to cite

Interferongamma inducible protein 10 IP10 induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway

https://doi.org/10.18632/oncotarget.4832
28042-28056
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

VATPase: a master effector of E2F1mediated lysosomal trafficking mTORC1 activation and autophagy

https://doi.org/10.18632/oncotarget.4812
28057-28070
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

FCGR2A FCGR3A polymorphisms and therapeutic efficacy of antiEGFR monoclonal antibody in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.4872
28071-28083
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells

https://doi.org/10.18632/oncotarget.4394
28084-28103
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

HIF isoforms have divergent effects on invasion metastasis metabolism and formation of lipid droplets

https://doi.org/10.18632/oncotarget.4612
28104-28119
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma

https://doi.org/10.18632/oncotarget.4866
28120-28131
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RUNX2 and TAZdependent signaling pathways regulate soluble ECadherin levels and tumorsphere formation in breast cancer cells

https://doi.org/10.18632/oncotarget.4654
28132-28150
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

LincRNAp21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4661
28151-28163
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types

https://doi.org/10.18632/oncotarget.4461
28164-28172
Abstract  |  PDF  |  Full Text  |  How to cite

Wholetranscriptome analysis links trastuzumab sensitivity of breast tumors to both HER2 dependence and immune cell infiltration

https://doi.org/10.18632/oncotarget.4405
28173-28182
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Na+/K+ATPase α1 subunit a novel therapeutic target for hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4726
28183-28193
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A poxviralbased cancer vaccine the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model

https://doi.org/10.18632/oncotarget.4442
28194-28210
Abstract  |  PDF  |  Full Text  |  How to cite

Gastrointestinal malignancies harbor actionable MET exon 14 deletions

https://doi.org/10.18632/oncotarget.4721
28211-28222
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

WT1mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCRABL oncogene

https://doi.org/10.18632/oncotarget.4950
28223-28237
Abstract  |  PDF  |  Full Text  |  How to cite

Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomeredependent genotoxic stress

https://doi.org/10.18632/oncotarget.4958
28238-28256
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Addiction of pancreatic cancer cells to zincfinger transcription factor ZIC2

https://doi.org/10.18632/oncotarget.4960
28257-28268
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The proteomic investigation reveals interaction of mdig protein with the machinery of DNA doublestrand break repair

https://doi.org/10.18632/oncotarget.4961
28269-28281
Abstract  |  PDF  |  Full Text  |  How to cite

Inhibition of adipose triglyceride lipase ATGL by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells

https://doi.org/10.18632/oncotarget.5061
28282-28295
Abstract  |  PDF  |  Full Text  |  How to cite

Fisetin a phytochemical potentiates sorafenibinduced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAFmutated melanoma cells

https://doi.org/10.18632/oncotarget.5064
28296-28311
Abstract  |  PDF  |  Full Text  |  How to cite

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

https://doi.org/10.18632/oncotarget.4873
28312-28326
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure

https://doi.org/10.18632/oncotarget.5069
28327-28340
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MiR23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL8/Stat3 pathway

https://doi.org/10.18632/oncotarget.5117
28341-28356
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

microRNA106bmediated downregulation of C1orf24 expression induces apoptosis and suppresses invasion of thyroid cancer

https://doi.org/10.18632/oncotarget.4947
28357-28370
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Regulation of p53 expression and apoptosis by vault RNA215p in cervical cancer cells

https://doi.org/10.18632/oncotarget.4948
28371-28388
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor2

https://doi.org/10.18632/oncotarget.4949
28389-28400
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for earlystage oral cancer patients through increased tumor cell invasion angiogenesis macrophage recruitment and interleukin6 production

https://doi.org/10.18632/oncotarget.4951
28401-28424
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NKX63 controls gastric differentiation and tumorigenesis

https://doi.org/10.18632/oncotarget.4952
28425-28439
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

ATAD2 overexpression links to enrichment of BMYBtranslational signatures and development of aggressive endometrial carcinoma

https://doi.org/10.18632/oncotarget.4955
28440-28452
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical Research Papers

Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials

https://doi.org/10.18632/oncotarget.4601
28453-28462
Abstract  |  PDF  |  Full Text  |  How to cite

A new computational model for human thyroid cancer enhances the preoperative diagnostic efficacy

https://doi.org/10.18632/oncotarget.4691
28463-28477
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High expression of XPA confers poor prognosis for nasopharyngeal carcinoma patients treated with platinumbased chemoradiotherapy

https://doi.org/10.18632/oncotarget.4424
28478-28490
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Vascular endothelial growth factor expression correlates with serum CA125 and represents a useful tool in prediction of refractoriness to platinumbased chemotherapy and ascites formation in epithelial ovarian cancer

https://doi.org/10.18632/oncotarget.4427
28491-28501
Abstract  |  PDF  |  Full Text  |  How to cite

Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network metaanalysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.4375
28502-28512
Abstract  |  PDF  |  Full Text  |  How to cite


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