Vol 6, No 29

LG24 and sex chromosomes

Targeting glutaminase and mTOR

Insight into miRNA biogenesis with RNA sequencing

LMOD3: the “missing link” in nemaline myopathy?

Pharmacological manipulation of AID

NKT10 cells: a novel iNKT cell subset

Regulation of extrathymic Treg cell conversion by CD5

RECQL: a DNA helicase in breast cancer

Targeting Batf2 for infectious diseases and cancer

The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas

Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration

To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

Serotonin 6 receptor controls alzheimer’s disease and depression

Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer

A network meta-analysis of the efficacy and side effects of udca-based therapies for primary sclerosing cholangitis

TGF-β isoforms in cancer: Immunohistochemical expression and Smad-pathway-activity-analysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity

Liver enzymes and metabolic syndrome: a large-scale case-control study

Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression

Notch signaling deregulation in multiple myeloma: A rational molecular target

Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation

BRAF mutation testing with a rapid, fully integrated molecular diagnostics system

A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

Dexamethasone-induced cell death is restricted to specific molecular subgroups of multiple myeloma

Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer

Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma

Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells

Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients

Carfilzomib enhances natural killer cell-mediated lysis of myeloma linked with decreasing expression of HLA class I

DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model

Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells

Integrative transcriptomics-based identification of cryptic drivers of taxol-resistance genes in ovarian carcinoma cells: Analysis of the androgen receptor

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2

SIRT1 in B[a]P-induced lung tumorigenesis

RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth

IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression

A core of kinase-regulated interactomes defines the neoplastic MDSC lineage

Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer

Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer

Combinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs

Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Chinese family with familial adenomatous coli

Low doses of X-rays induce prolonged and ATM-independent persistence of γH2AX foci in human gingival mesenchymal stem cells

Sphere-derived tumor cells exhibit impaired metastasis by a host-mediated quiescent phenotype

Detection and enumeration of circulating tumor cells based on their invasive property

Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells

Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8⁺ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo

STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene

Nuclear estrogen receptor-α expression is an independent predictor of recurrence in male patients with pT1aN0 lung adenocarcinomas, and correlates with regulatory T-cell infiltration

Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells

Dequalinium blocks macrophage-induced metastasis following local radiation

Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2α/androgen receptor signals

Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy

Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1

By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Stichoposide D inhibits growth of leukemia xenografts

Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression

Zinc finger transcription factor CASZ1 interacts with histones, DNA repair proteins and recruits NuRD complex to regulate gene transcription

NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer

IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules

Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer

Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis

Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model

Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma

MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4

Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of stathmin1

MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells

Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma

Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site

LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2

Immunoprofile from tissue microarrays to stratify familial breast cancer patients

A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel

USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2

Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells

Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

Automated tumor analysis for molecular profiling in lung cancer

Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma

Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines

AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer

Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

FCGR2A, FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal antibody in metastatic colorectal cancer

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma

RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells

LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma

Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types

Whole-transcriptome analysis links trastuzumab sensitivity of breast tumors to both HER2 dependence and immune cell infiltration

Na⁺/K⁺-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma

A poxviral-based cancer vaccine targeting the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model

Gastrointestinal malignancies harbor actionable MET exon 14 deletions

WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene

Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16^INK4a deficiency and telomere-dependent genotoxic stress

Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2

The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair

Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells

Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure

MiR-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL-8/Stat3 pathway

microRNA-106b-mediated down-regulation of C1orf24 expression induces apoptosis and suppresses invasion of thyroid cancer

Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells

Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2

Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production

NKX6.3 controls gastric differentiation and tumorigenesis

ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma

A new computational model for human thyroid cancer enhances the preoperative diagnostic efficacy

High expression of XPA confers poor prognosis for nasopharyngeal carcinoma patients treated with platinum-based chemoradiotherapy

Vascular endothelial growth factor expression correlates with serum CA125 and represents a useful tool in prediction of refractoriness to platinum-based chemotherapy and ascites formation in epithelial ovarian cancer

Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network meta-analysis of randomized controlled trials