NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer
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Yunlong Li1,*, Yaohui Li1,*, Wenping Chen1,*, Fenfei He1, Zhaobang Tan1, Jianyong Zheng1, Weizhong Wang1, Qingchuan Zhao1, Jipeng Li1
1Department of Gastrointestinal Surgery, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
*These authors have contributed equally to this work
Jipeng Li, e-mail: firstname.lastname@example.org
Qingchuan Zhao, e-mail: email@example.com
Keywords: NEAT1, colorectal cancer, relapse, prognosis
Received: February 11, 2015 Accepted: July 27, 2015 Published: August 07, 2015
Long noncoding RNAs (lncRNAs) have recently been identified to be involved in various diseases including cancer. NEAT1 is a recently identified lncRNA with its function largely unknown in human malignancy. In the present study, we investigated NEAT1 expression in 239 cases of clinical colorectal cancer specimens and matched normal tissues. Statistical methods were utilized to analyze the association of NEAT1 with clinical features, disease-free and overall survival of patients. Results showed that NEAT1 expression in colorectal cancer was up-regulated in 72.0% (172/239) cases compared with corresponding normal counterparts, and related to tumor differentiation, invasion, metastasis and TNM stage. Kaplan-Meier analysis proved that NEAT1 was associated with both disease-free survival and overall survival of patients with colorectal cancer that patients with high NEAT1 expression tend to have unfavorable outcome. Moreover, cox's proportional hazards analysis showed that high NEAT1 expression was an independent prognostic marker of poor outcome. These results provided the first evidence that the expression of NEAT1 in colorectal cancer may play an oncogenic role in colorectal cancer differentiation, invasion and metastasis. It also proved that NEAT1 may serve as an indicator of tumor recurrence and prognosis of colorectal cancer.
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