Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population
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Yun-Miao Guo1,2,*, Ming-Xia Sun1,2,*, Jing Li3,*, Tong-Tong Liu1,2, Hang-Zhen Huang1,2, Jie-Rong Chen1,2, Wen-Sheng Liu1,2, Qi-Sheng Feng1,2, Li-Zhen Chen1,2, Jin-Xin Bei1,2, Yi-Xin Zeng1,2,4,*
1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
2Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China
3Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China
4Peking Union Medical College, Beijing, P. R. China
*These authors have contributed equally to this work
Yi-Xin Zeng, e-mail: firstname.lastname@example.org
Keywords: nasopharyngeal carcinoma, SNP, CELF2, prognosis
Received: March 27, 2015 Accepted: July 30, 2015 Published: August 11, 2015
Nasopharyngeal carcinoma (NPC) is a malignancy with high metastatic potential and loco-regional recurrence. The overall survival of NPC has been limited from further improvement partly due to the lack of effective biomarker for accurate prognosis prediction and precise treatments. Here, in light of the implication of CELF gene family in cancer prognosis, we selected 112 tagging single nucleotide polymorphisms (SNPs) located in six members of the family and tested their associations with the clinical outcomes in a discovery cohort of 717 NPC patients. Survival analyses under multivariate cox proportional hazards model and Kaplan–Meier curve revealed five promising SNPs, which were further validated in another independent sample of 1,520 cases. Combined analysis revealed that SNP rs3740194 in CELF2 was significantly associated with the decreased risk of death with a Hazard ratio (HR) of 0.69 (95% confidence interval [CI] = 0.58–0.82, codominant model). Moreover, rs3740194 also showed a significant association with superior metastasis-free survival (HR = 0.69, 95% CI = 0.57–0.83, codominant model). Taken together, our findings suggested that genetic variant of rs3740194 in CELF2 gene might be a valuable predictor for NPC prognosis, and potentially useful in the personalized treatment of NPC.
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