Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer
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Chao-Chih Wu1,3, Yuh-Cheng Yang2, Yun-Ting Hsu3, T.-C. Wu5,6,7,8, Chien-Fu Hung5,6,7,8, Jung-Tang Huang1, Chih-Long Chang2,3,4
1Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei City, Taiwan
2Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei City, Taiwan
3Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan
4Department of Medicine, Mackay Medical College, Sanchi, New Taipei City, Taiwan
5Department of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA
6Department of Oncology, The Johns Hopkins University, Baltimore, Maryland, USA
7Department of Obstetrics and Gynecology, The Johns Hopkins University, Baltimore, Maryland, USA
8Department of Molecular Microbiology and Immunology, The Johns Hopkins University, Baltimore, Maryland, USA
Chih-Long Chang, e-mail: [email protected]
Jung-Tang Huang, e-mail: [email protected]
Keywords: hypethermia, gold nanoshells, ovarian cancer
Received: April 23, 2015 Accepted: July 22, 2015 Published: August 03, 2015
Hyperthermic intraperitoneal chemotherapy is effective in treating various intra-abdominal malignancies. However, this therapeutic modality can only be performed during surgical operations and cannot be used repeatedly. We propose repeatedly noninvasive hyperthermia mediated by pegylated silica-core gold nanoshells (pSGNs) in vivo with external near-infrared (NIR) laser irradiation. This study demonstrated that repeated photothermal treatment can effectively eliminate intraperitoneal tumors in mouse ovarian cancer models without damage of normal tissues. By conjugating pSGNs with anti-human CD47 monoclonal antibody, a significant photoablative effect can be achieved using lower amount of pSGNs and shorter NIR laser irradiation. Conjugated pSGNs specifically targeted and bound to cancer cells inside the peritoneal cavity. Our results indicate the possibility of a noninvasive method of repeated hyperthermia and photoablative therapies using nanoparticles. This has substantial clinical potential in treating ovarian and other intraperitoneal cancers.
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