Oncotarget

Research Papers:

Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

Chao-Chih Wu, Yuh-Cheng Yang, Yun-Ting Hsu, T.-C. Wu, Chien-Fu Hung, Jung-Tang Huang and Chih-Long Chang _

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Oncotarget. 2015; 6:26861-26875. https://doi.org/10.18632/oncotarget.4766

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Abstract

Chao-Chih Wu1,3, Yuh-Cheng Yang2, Yun-Ting Hsu3, T.-C. Wu5,6,7,8, Chien-Fu Hung5,6,7,8, Jung-Tang Huang1, Chih-Long Chang2,3,4

1Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei City, Taiwan

2Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei City, Taiwan

3Department of Medical Research, Mackay Memorial Hospital, Taipei City, Taiwan

4Department of Medicine, Mackay Medical College, Sanchi, New Taipei City, Taiwan

5Department of Pathology, The Johns Hopkins University, Baltimore, Maryland, USA

6Department of Oncology, The Johns Hopkins University, Baltimore, Maryland, USA

7Department of Obstetrics and Gynecology, The Johns Hopkins University, Baltimore, Maryland, USA

8Department of Molecular Microbiology and Immunology, The Johns Hopkins University, Baltimore, Maryland, USA

Correspondence to:

Chih-Long Chang, e-mail: clchang@mmc.edu.tw

Jung-Tang Huang, e-mail: jthuang@ntut.edu.tw

Keywords: hypethermia, gold nanoshells, ovarian cancer

Received: April 23, 2015     Accepted: July 22, 2015     Published: August 03, 2015

ABSTRACT

Hyperthermic intraperitoneal chemotherapy is effective in treating various intra-abdominal malignancies. However, this therapeutic modality can only be performed during surgical operations and cannot be used repeatedly. We propose repeatedly noninvasive hyperthermia mediated by pegylated silica-core gold nanoshells (pSGNs) in vivo with external near-infrared (NIR) laser irradiation. This study demonstrated that repeated photothermal treatment can effectively eliminate intraperitoneal tumors in mouse ovarian cancer models without damage of normal tissues. By conjugating pSGNs with anti-human CD47 monoclonal antibody, a significant photoablative effect can be achieved using lower amount of pSGNs and shorter NIR laser irradiation. Conjugated pSGNs specifically targeted and bound to cancer cells inside the peritoneal cavity. Our results indicate the possibility of a noninvasive method of repeated hyperthermia and photoablative therapies using nanoparticles. This has substantial clinical potential in treating ovarian and other intraperitoneal cancers.


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