Volume 9, Issue 17 | Oncotarget

About The Cover

The cover for issue 17 of Oncotarget features Figure 4B, "A comparison of the structural elements comprising human PHGDH, sPHGDH and PHGDH-93. Amino acids involved in hydrogen bond formation to the substrate (*) or cofactor NAD+ (*) are highlighted," from Unterlass, et al.

Research Papers: Pathology

The SRCfamily tyrosine kinase HCK shapes the landscape of SKAP2 interactome	The SRCfamily tyrosine kinase HCK shapes the landscape of SKAP2 interactome
https://doi.org/10.18632/oncotarget.24424 Jean-FranÃ§ois Bureau, Patricia Cassonnet, Laura Grange, Julien Dessapt, Louis Jones, Caroline Demeret, Anavaj Sakuntabhai, and Yves Jacob
13102-13115

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Research Papers: Immunology

Correlation and agreement between eplet mismatches calculated using serological lowintermediate and high resolution molecular human leukocyte antigen typing methods	Correlation and agreement between eplet mismatches calculated using serological lowintermediate and high resolution molecular human leukocyte antigen typing methods
https://doi.org/10.18632/oncotarget.24349 Samantha Fidler, Lloyd Dâ€™Orsogna, Ashley B. Irish, Joshua R. Lewis, Germaine Wong, and Wai H. Lim
13116-13124

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IL21 modulates memory and exhaustion phenotype of Tcells in a fatty acid oxidationdependent manner	IL21 modulates memory and exhaustion phenotype of Tcells in a fatty acid oxidationdependent manner
https://doi.org/10.18632/oncotarget.24442 Romy Loschinski, Martin BÃ¶ttcher, Andrej Stoll, Heiko Bruns, Andreas Mackensen, and Dimitrios Mougiakakos
13125-13138

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Research Papers

Validating and enabling phosphoglycerate dehydrogenase PHGDH as a target for fragmentbased drug discovery in PHGDHamplified breast cancer	Validating and enabling phosphoglycerate dehydrogenase PHGDH as a target for fragmentbased drug discovery in PHGDHamplified breast cancer
https://doi.org/10.18632/oncotarget.11487 Judith E. Unterlass, Arnaud BaslÃ©, Timothy J. Blackburn, Julie Tucker, CÃ©line Cano, Martin E.M. Noble, and Nicola J. Curtin
13139-13153

Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells	Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells
https://doi.org/10.18632/oncotarget.22743 Hua Chen, Jacson Shen, Edwin Choy, Francis J. Hornicek, Aijun Shan, and Zhenfeng Duan
13154-13166

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Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells	Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells
https://doi.org/10.18632/oncotarget.23481 Hsin-Pao Chen, Yung-Kuo Lee, Shih Yin Huang, Pei-Chun Shi, Ping-Chi Hsu, and Chuan-Fa Chang
13167-13180

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Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for antiepilepsy drug discovery	Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for antiepilepsy drug discovery
https://doi.org/10.18632/oncotarget.23719 Ze-Jia Cui, Ye-Mao Liu, Qiang Zhu, Jingbo Xia, and Hong-Yu Zhang
13181-13192

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EIF3Cenhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma	EIF3Cenhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma
https://doi.org/10.18632/oncotarget.24149 Hsin-Yi Lee, Chi-Kuan Chen, Chun-Ming Ho, Szu-Shuo Lee, Chieh-Yu Chang, Kuan-Ju Chen, and Yuh-Shan Jou
13193-13205

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Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448	Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448
https://doi.org/10.18632/oncotarget.24152 Simeon Cua, Heng Liang Tan, Wey Jia Fong, Angela Chin, Ally Lau, Vanessa Ding, Zhiwei Song, Yuansheng Yang, and Andre Choo
13206-13221

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The singlenucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma	The singlenucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma
https://doi.org/10.18632/oncotarget.23812 Xiao Zhu, Qingming Kong, Liwei Xie, Zhihong Chen, Hongmei Li, Zhu Zhu, Yongmei Huang, Feifei Lan, Haiqing Luo, Jingting Zhan, Hongrong Ding, Jinli Lei, Qin Xiao, Weiming Fu, Wenguo Fan, Jinfang Zhang, and Hui Luo
13222-13230

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Reprogrammed lipid metabolism in bladder cancer with cisplatin resistance	Reprogrammed lipid metabolism in bladder cancer with cisplatin resistance
https://doi.org/10.18632/oncotarget.24229 Min Young Lee, Austin Yeon, Muhammad Shahid, Eunho Cho, Vikram Sairam, Robert Figlin, Khae-Hwan Kim, and Jayoung Kim
13231-13243

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miR128 inhibits telomerase activity by targeting TERT mRNA	miR128 inhibits telomerase activity by targeting TERT mRNA
https://doi.org/10.18632/oncotarget.24284 Herlinda Guzman, Katie Sanders, Adam Idica, Aurore Bochnakian, Douglas Jury, Iben Daugaard, Dimitrios G Zisoulis, and Irene Munk Pedersen
13244-13253

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Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function cell migration and cancer stem cell CSC signalling	Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function cell migration and cancer stem cell CSC signalling
https://doi.org/10.18632/oncotarget.24285 Maria Peiris-PagÃ¨s, Gloria Bonuccelli, Federica Sotgia, and Michael P. Lisanti
13254-13275

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Neutrophil extracellular traps promote lipopolysaccharideinduced airway inflammation and mucus hypersecretion in mice	Neutrophil extracellular traps promote lipopolysaccharideinduced airway inflammation and mucus hypersecretion in mice
https://doi.org/10.18632/oncotarget.24022 Yong Zou, Xi Chen, Jian Xiao, Dong Bo Zhou, Xiao Xiao Lu, Wei Li, Bin Xie, Xiao Kuang, and Qiong Chen
13276-13286

Deficiency of proteinLisoaspartate Daspartate Omethyltransferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma	Deficiency of proteinLisoaspartate Daspartate Omethyltransferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma
https://doi.org/10.18632/oncotarget.24324 Masahiro Yamashita, Masahito Ogasawara, Yasushi Kawasaki, Miyuki Niisato, Heisuke Saito, Shuya Kasai, Chihaya Maesawa, Makoto Maemondo, and Kohei Yamauchi
13287-13300

Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PDL1 blockade therapy	Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PDL1 blockade therapy
https://doi.org/10.18632/oncotarget.24327 Naoto Nishii, Hidetake Tachinami, Yuta Kondo, Yulong Xia, Yoshihisa Kashima, Tatsukuni Ohno, Shigenori Nagai, Lixin Li, Walter Lau, Hiroyuki Harada, and Miyuki Azuma
13301-13312

CD151 promotes cell metastasis via activating TGFβ1/Smad signaling in renal cell carcinoma	CD151 promotes cell metastasis via activating TGFβ1/Smad signaling in renal cell carcinoma
https://doi.org/10.18632/oncotarget.24028 Yajie Yu, Chao Liang, Shangqian Wang, Jundong Zhu, Chenkui Miao, Yibo Hua, Meiling Bao, Qiang Cao, Chao Qin, Pengfei Shao, and Zengjun Wang
13313-13323

Methotrexate sensitizes drugresistant metastatic melanoma cells to BRAF V600E inhibitors dabrafenib and encorafenib	Methotrexate sensitizes drugresistant metastatic melanoma cells to BRAF V600E inhibitors dabrafenib and encorafenib
https://doi.org/10.18632/oncotarget.24341 Kayleigh C. Ross, Kevin F. Chin, Daehwan Kim, Christopher D. Marion, Timothy J. Yen, and Vikram Bhattacharjee
13324-13336

Colorectal cancer cells require glycogen synthase kinase3β for sustaining mitosis via translocated promoter region TPRdynein interaction	Colorectal cancer cells require glycogen synthase kinase3β for sustaining mitosis via translocated promoter region TPRdynein interaction
https://doi.org/10.18632/oncotarget.24344 Firli R.P. Dewi, Takahiro Domoto, Masaharu Hazawa, Akiko Kobayashi, Takayuki Douwaki, Toshinari Minamoto, and Richard W. Wong
13337-13352

The metalnonoate NiSalPipNONO inhibits in vitro tumor growth invasiveness and angiogenesis	The metalnonoate NiSalPipNONO inhibits in vitro tumor growth invasiveness and angiogenesis
https://doi.org/10.18632/oncotarget.24350 Valerio Ciccone, Martina Monti, Enrico Monzani, Luigi Casella, and Lucia Morbidelli
13353-13365

Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin^Â® protein MP0250: a preclinical study	Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin^Â® protein MP0250: a preclinical study
https://doi.org/10.18632/oncotarget.24351 Luigia Rao, Kim De Veirman, Donato Giannico, Ilaria Saltarella, Vanessa Desantis, Maria Antonia Frassanito, Antonio Giovanni Solimando, Domenico Ribatti, Marcella Prete, Andreas Harstrick, Ulrike Fiedler, Hendrik De Raeve, Vito Racanelli, Karin Vanderkerken, and Angelo Vacca
13366-13381

Efficacy of different spinal nerve roots for neuromodulation of micturition reflex in rats	Efficacy of different spinal nerve roots for neuromodulation of micturition reflex in rats
https://doi.org/10.18632/oncotarget.23950 Jianshu Ni, Xiaohu Wang, Nailong Cao, Jiemin Si, and Baojun Gu
13382-13389

Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR224	Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR224
https://doi.org/10.18632/oncotarget.24385 Yung-Lung Chang, Shu-Ting Liu, Yi-Wen Wang, Wei-Shiang Lin, and Shih-Ming Huang
13390-13406

Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis	Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis
https://doi.org/10.18632/oncotarget.24388 Michael P. Marciel, Vedbar S. Khadka, Youping Deng, Pascal Kilicaslan, Andrew Pham, Pietro Bertino, Katie Lee, Suzie Chen, Natalija Glibetic, FuKun W. Hoffmann, Michelle L. Matter, and Peter R. Hoffmann
13407-13422

The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro	The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro
https://doi.org/10.18632/oncotarget.24393 Laura N. Eadie, Verity A. Saunders, Susan Branford, Deborah L. White, and Timothy P. Hughes
13423-13437

Trifluridine/tipiracil overcomes the resistance of human gastric 5fluorouracilrefractory cells with high thymidylate synthase expression	Trifluridine/tipiracil overcomes the resistance of human gastric 5fluorouracilrefractory cells with high thymidylate synthase expression
https://doi.org/10.18632/oncotarget.24412 Kazuaki Matsuoka, Fumio Nakagawa, Takashi Kobunai, and Teiji Takechi
13438-13450

Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL	Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL
https://doi.org/10.18632/oncotarget.24413 Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Satoshi Baba, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Aki Yamashita, Satoko Eguchi, Kensuke Tomio, Mayuyo Mori-Uchino, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, and Tomoyuki Fujii
13451-13461

Gramnegative bacteria facilitate tumor progression through TLR4/IL33 pathway in patients with nonsmallcell lung cancer	Gramnegative bacteria facilitate tumor progression through TLR4/IL33 pathway in patients with nonsmallcell lung cancer
https://doi.org/10.18632/oncotarget.24008 Mengyao Sun, Yang Bai, Song Zhao, Xiyu Liu, Yongsheng Gao, Lei Wang, Bin Liu, Dashi Ma, and Chunye Ma
13462-13473

CDK8/19 inhibition induces premature G1/S transition and ATRdependent cell death in prostate cancer cells	CDK8/19 inhibition induces premature G1/S transition and ATRdependent cell death in prostate cancer cells
https://doi.org/10.18632/oncotarget.24414 Akito Nakamura, Daisuke Nakata, Yuichi Kakoi, Mihoko Kunitomo, Saomi Murai, Shunsuke Ebara, Akito Hata, and Takahito Hara
13474-13487

Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma	Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma
https://doi.org/10.18632/oncotarget.24416 Maria Fernanda SetÃºbal Destro Rodrigues, Luke Gammon, Muhammad M. Rahman, Adrian Biddle, Fabio Daumas Nunes, and Ian C. Mackenzie
13488-13500

Increased expression of MNK1b the spliced isoform of MNK1 predicts poor prognosis and is associated with triplenegative breast cancer	Increased expression of MNK1b the spliced isoform of MNK1 predicts poor prognosis and is associated with triplenegative breast cancer
https://doi.org/10.18632/oncotarget.24417 Celia Pinto-DÃez, Eva M. GarcÃa-Recio, M. Isabel PÃ©rez-Morgado, Marta GarcÃa-HernÃ¡ndez, Lara Sanz-Criado, Silvia SacristÃ¡n, M. Val Toledo-Lobo, BelÃ©n PÃ©rez-Mies, Isabel Esteban-RodrÃguez, Alejandro Pascual, Mercedes Garcia-Villanueva, Noelia MartÃnez-JaÃ±ez, VÃctor M. GonzÃ¡lez, and M. Elena MartÃn
13501-13516

An open label trial of folate receptortargeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas	An open label trial of folate receptortargeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas
https://doi.org/10.18632/oncotarget.24399 Jarrod D. Predina, Andrew D. Newton, Leilei Xia, Christopher Corbett, Courtney Connolly, Michael Shin, Lydia Frezel Sulyok, Leslie Litzky, Charuhas Deshpande, Shuming Nie, Sumith A. Kularatne, Phillip S. Low, and Sunil Singhal
13517-13529

Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas	Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas
https://doi.org/10.18632/oncotarget.24418 Apurva Atak, Samiksha Khurana, Kishore Gollapalli, Panga Jaipal Reddy, Roei Levy, Stav Ben-Salmon, Dror Hollander, Maya Donyo, Anke Heit, Agnes Hotz-Wagenblatt, Hadas Biran, Roded Sharan, Shailendra Rane, Ashutosh Shelar, Gil Ast, and Sanjeeva Srivastava
13530-13544

CHL1 gene polymorphisms increase lung cancer susceptibility	CHL1 gene polymorphisms increase lung cancer susceptibility
https://doi.org/10.18632/oncotarget.24057 Wen Tian, Xuelian Li, Yangwu Ren, Zhihua Yin, Xiaowei Quan, Chang Zheng, and Baosen Zhou
13545-13550

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About The Cover

Table of Contents

Research Papers: Pathology

Research Papers: Immunology

Research Papers

Meta-Analysis

Clinical Research Papers

Reviews

Corrections

Molecular profiling of ALDH1⁺ colorectal cancer stem cells reveals preferential activation of MAPK FAK and oxidative stress prosurvival signalling pathways	Molecular profiling of ALDH1⁺ colorectal cancer stem cells reveals preferential activation of MAPK FAK and oxidative stress prosurvival signalling pathways
https://doi.org/10.18632/oncotarget.24420 Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Mohamed Fahad, Rimi Hamam, Musaad Alfayez, Moustapha Kassem, Abdullah Aldahmash, and Nehad M. Alajez
13551-13564

Human tripartite motif protein 52 is required for cell contextdependent proliferation	Human tripartite motif protein 52 is required for cell contextdependent proliferation
https://doi.org/10.18632/oncotarget.24422 Stefan Benke, Benedikt Agerer, Lisa Haas, Martin StÃ¶ger, Alexander Lercher, Lisa Gabler, Izabella Kiss, Sara Scinicariello, Walter Berger, Andreas Bergthaler, Anna C. Obenauf, and Gijs A. Versteeg
13565-13581

Leukocyte telomere length throughout the continuum of colorectal carcinogenesis	Leukocyte telomere length throughout the continuum of colorectal carcinogenesis
https://doi.org/10.18632/oncotarget.24431 Cornelia ZÃ¶chmeister, Stefanie Brezina, Philipp Hofer, Andreas Baierl, Michael M. Bergmann, Thomas Bachleitner-Hofmann, Judith Karner-Hanusch, Anton Stift, Armin Gerger, Gernot Leeb, Karl Mach, Sivaramakrishna Rachakonda, Rajiv Kumar, and Andrea Gsur
13582-13592

Adenosine A_2A receptor ligand recognition and signaling is blocked by A_2B receptors	Adenosine A_2A receptor ligand recognition and signaling is blocked by A_2B receptors
https://doi.org/10.18632/oncotarget.24423 Sonja Hinz, Gemma Navarro, Dasiel Borroto-Escuela, Benjamin F. Seibt, York-Christoph Ammon, Elisabetta de Filippo, Azeem Danish, Svenja K. Lacher, Barbora ÄŒervinkovÃ¡, Muhammad Rafehi, Kjell Fuxe, Anke C. Schiedel, Rafael Franco, and Christa E. MÃ¼ller
13593-13611

Nuclear myosin/actinmotored contact between homologous chromosomes is initiated by ATM kinase and homologydirected repair proteins at doublestrand DNA breaks to suppress chromosome rearrangements	Nuclear myosin/actinmotored contact between homologous chromosomes is initiated by ATM kinase and homologydirected repair proteins at doublestrand DNA breaks to suppress chromosome rearrangements
https://doi.org/10.18632/oncotarget.24434 Viktoria N. Evdokimova, Manoj Gandhi, Alyaksandr V. Nikitski, Christopher J. Bakkenist, and Yuri E. Nikiforov
13612-13622

Prolonged in vivo expression and antitumor response of DNAbased antiHER2 antibodies	Prolonged in vivo expression and antitumor response of DNAbased antiHER2 antibodies
https://doi.org/10.18632/oncotarget.24426 Kevin Hollevoet, Elien De Smidt, Nick Geukens, and Paul Declerck
13623-13636

Protective role of integrinlinked kinase against oxidative stress and in maintenance of genomic integrity	Protective role of integrinlinked kinase against oxidative stress and in maintenance of genomic integrity
https://doi.org/10.18632/oncotarget.24444 Michelle Im, and Lina Dagnino
13637-13651

Structural insights into drug development strategy targeting EGFR T790M/C797S	Structural insights into drug development strategy targeting EGFR T790M/C797S
https://doi.org/10.18632/oncotarget.24113 Su-Jie Zhu, Peng Zhao, Jiao Yang, Rui Ma, Xiao-E Yan, Sheng-Yong Yang, Jing-Wen Yang, and Cai-Hong Yun
13652-13665

Persistent DNA strand breaks induce a CAFlike phenotype in normal fibroblasts	Persistent DNA strand breaks induce a CAFlike phenotype in normal fibroblasts
https://doi.org/10.18632/oncotarget.24446 Arnaud J. Legrand, Mattia Poletto, Daniela Pankova, Elena Clementi, John Moore, Francesc Castro-Giner, Anderson J. Ryan, Eric Oâ€™Neill, Enni Markkanen, and Grigory L. Dianov
13666-13681

Correlation of MET gene amplification and TP53 mutation with PDL1 expression in nonsmall cell lung cancer	Correlation of MET gene amplification and TP53 mutation with PDL1 expression in nonsmall cell lung cancer
https://doi.org/10.18632/oncotarget.24455 Maher Albitar, Sucha Sudarsanam, Wanlong Ma, Shiping Jiang, Wayne Chen, Vincent Funari, Forrest Blocker, and Sally Agersborg
13682-13693