Clinical Research Papers:

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting longterm major adverse cardiac events in STEMI patients undergoing primary PCI

Xue-Wei Chang _, Shou-Yan Zhang, Hao Wang, Ming-Ming Zhang, Wei-Feng Zheng, Hui-Fang Ma, Yun-Fei Gu, Jing-Han Wei and Chun-Guang Qiu

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Oncotarget. 2018; 9:13971-13980. https://doi.org/10.18632/oncotarget.24128

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Xue-Wei Chang1,2,*, Shou-Yan Zhang 2,*, Hao Wang 2, Ming-Ming Zhang2, Wei-Feng Zheng2, Hui-Fang Ma2, Yun-Fei Gu2, Jing-Han Wei1 and Chun-Guang Qiu1

1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

2Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 471009, China

*These authors contributed equally to this work

Correspondence to:

Chun-Guang Qiu, email: [email protected]

Keywords: myocardial infarction, red cell distribution width, coronary artery, percutaneous coronary intervention

Received: August 23, 2017     Accepted: December 03, 2017     Published: January 10, 2018


The combined value of RDW and GRACE risk score for cardiovascular prognosis in ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) has not been fully investigated. This study was designed to explore the combined value of RDW and GRACE risk score on predicting long-term major adverse cardiac event (Mace) in STEMI patients undergoing primary PCI. This study included 390 STEMI patients. The primary endpoint at the (33.5 ± 7.1) months follow-up was composed of cardiac death and nonfatal myocardial infarction. The relationship between clinical parameters and clinical outcomes was evaluated using Cox regression model and receiver operating characteristic (ROC) analysis. Mace occurred in 126 (32.3%) patients including 54 (13.8%) cardiac deaths and 72 (18.5%) nonfatal myocardial infarctions. Patients in Mace group had significantly higher RDW and GRACE score than the patients in non-Mace group. According to the Cox model, RDW and GRACE score were the most important independent predictors of Mace and cardiac death. The best cut-off value for RDW to predict the occurrence of primary events was 13.25% (AUC = 0.694, 95% CI:0.639–0.750, P < 0.001) and that for GRACE score was 119.5 (AUC = 0.721, 95% CI:0.666–0.777, P < 0.001). The combination of RDW and GRACE score were more valuable (AUC = 0.775, 95% CI: 0.727–0.824, P < 0.001). Kaplan–Meier analysis provided significant prognostic information with the highest risk for cardiac death (Log-Rank χ2 = 24.684, P < 0.001) in group with both high RDW (> 13.25%) and high GRACE score (> 119.5). The combination of RDW level and GRACE score may be valuable and simple independent predictors of Mace and cardiac death in STEMI patients undergoing primary PCI. They may be useful tools for risk stratification and may indicate long-term clinical outcomes.

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