Clinical Research Papers:

Prevalence of non-syndromic orofacial clefts: based on 15,094,978 Chinese perinatal infants

Dazhi Fan _, Shuzhen Wu, Li Liu, Qing Xia, Guo Tian, Wen Wang, Shaoxin Ye, Lijuan Wang, Jiaming Rao, Xiao Yang, Zhen Yu, Lihong Xin, Song Li, Zhenghua Duan, Tianchen Zhang, Song Wu, Xiaoling Guo and Zhengping Liu

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Oncotarget. 2018; 9:13981-13990. https://doi.org/10.18632/oncotarget.24238

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Dazhi Fan1,2, Shuzhen Wu1,2, Li Liu3,5, Qing Xia3,6, Guo Tian5, Wen Wang2, Shaoxin Ye1,2, Lijuan Wang2, Jiaming Rao1,7, Xiao Yang3,8, Zhen Yu9, Lihong Xin10, Song Li11, Zhenghua Duan12, Tianchen Zhang13, Song Wu4, Xiaoling Guo1,2 and Zhengping Liu1,2

1Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, Guangdong, 528000, China

2Department of Obstetrics, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, Guangdong, 528000, China

3Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China

4School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, China

5Department of Library, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China

6Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia

7Department of Epidemiology, Medical College of Jinan University, Guangzhou, Guangdong, 510632, China

8Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu, 213003, China

9Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China

10Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China

11Chaohu Hospital Affiliated Anhui Medical University, Chaohu, Anhui, 238000, China

12Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan, 610041, China

13Department of Communicable Diseases Control, Jiangxi Provincial Center for Disease Control and Prevention, Nanchang 330000, Jiangxi, China

Correspondence to:

Zhengping Liu, email: [email protected]

Xiaoling Guo, email: [email protected]

Keywords: non-syndromic orofacial clefts; perinatal infants; prevalence; meta-analysis; China

Received: June 27, 2017     Accepted: December 05, 2017     Published: January 13, 2018


Non-syndromic orofacial clefts (NSOFC), which include cleft lip and palate (CLP), cleft lip only (CLO), and cleft palate only (CPO), contains a range of disorders affecting the lips and oral cavity. No systematic review and meta-analysis has been carried out to synthesize the prevalence of NSOFC in Chinese perinatal infants. We aimed to quantify and understand the variation of prevalence national and regional levels. Four English databases and four Chinese databases were searched using a comprehensive search strategy from inception to April 2017. The random effect model was used for this meta-analysis. To determine the sources of heterogeneity, subgroup analyses and meta-regression were conducted based on different categories. The protocol has been pre-registered in the PROSPERO, number CRD42017062293. 110 studies, including 15,094,978 Chinese perinatal infants, were eligible for inclusion. The pooled prevalence rate for NSOFC was 1.67‰ (95% CI 1.53–1.82), varying with provinces. The pooled prevalence estimate was 0.56‰ (0.50–0.63) for CLO, 0.82‰ (0.73–0.90) for CLP, and 0.27‰ (0.24–0.30) for CPO. Significant associations were found between overall prevalence estimates and survey year and study region. The prevalence of NSOFC was severe in Chinese perinatal infants, varying with provinces. The results will serve as a baseline for future assessment of the overall effectiveness of NSOFC control, and will also support and inform health policy for planning and helping health debates.

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