Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism

CLEC4C p.K210del variant causes impaired cell surface transport in plasmacytoid dendritic cells of amyotrophic lateral sclerosis

Down-regulating cyclin-dependent kinase 9 of alloreactive CD4+ T cells prolongs allograft survival

Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization

Oncogenic kinase fusions: an evolving arena with innovative clinical opportunities

ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

Inhibiting cell migration and cell invasion by silencing the transcription factor ETS-1 in human bladder cancer

The next generation of metastatic melanoma: uncovering the genetic variants for anti-BRAF therapy response

Large-scale profiling of signalling pathways reveals an asthma specific signature in bronchial smooth muscle cells

Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13- acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCδ- and Wnt-1/β-catenin-mediated pathways

The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells

Lin^neg Sca-1^high CD49f^high prostate cancer cells derived from the Hi-Myc mouse model are tumor-initiating cells with basal-epithelial characteristics and differentiation potential in vitro and in vivo

Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia

mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer

Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma

Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma

MiR-424 and miR-27a increase TRAIL sensitivity of acute myeloid leukemia by targeting PLAG1

Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer

PGE2-EP3 signaling pathway contributes to protective effects of misoprostol on cerebral injury in APP/PS1 mice

Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer

CCL20 mediates RANK/RANKL-induced epithelial-mesenchymal transition in endometrial cancer cells

Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer

Ftx non coding RNA-derived miR-545 promotes cell proliferation by targeting RIG-I in hepatocellular carcinoma

Chronic TGFβ stimulation promotes the metastatic potential of lung cancer cells by Snail protein stabilization through integrin β3-Akt-GSK3β signaling

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma

Salivary HOTAIR and PVT1 as novel biomarkers for early pancreatic cancer

XB130 deficiency enhances lipopolysaccharide-induced septic response and acute lung injury

mTOR regulates proteasomal degradation and Dp1/E2F1- mediated transcription of KPNA2 in lung cancer cells

Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins

Preoperative serum fibrinogen is an independent prognostic factor in operable esophageal cancer

Association of genetic variants in lncRNA H19 with risk of colorectal cancer in a Chinese population

Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress

A novel scoring system predicts adjuvant chemolipiodolization benefit for hepatocellular carcinoma patients after hepatectomy

ERK2 phosphorylation of EBNA1 serine 383 residue is important for EBNA1-dependent transactivation

Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer

Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer

Small flexible structure for targeted delivery of therapeutic and imaging moieties in precision medicine

Phase I trial evaluating the antiviral agent Cidofovir in combination with chemoradiation in cervical cancer patients

Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell lung cancer

Interim analysis of postoperative chemoradiotherapy with capecitabine and oxaliplatin versus capecitabine alone for pathological stage II and III rectal cancer: a randomized multicenter phase III trial

FOXO4 and FOXD3 are predictive of prognosis in gastric carcinoma patients

Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device

Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M

Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer

A window of opportunity study of potential tumor and soluble biomarkers of response to preoperative erlotinib in early stage non-small cell lung cancer

Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of nuclear factor (erythroid-derived 2)-like 2

Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death

Long noncoding RNA MALAT1 promotes malignant development of esophageal squamous cell carcinoma by targeting β-catenin via Ezh2

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages

Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow

EFEMP1 is repressed by estrogen and inhibits the epithelial-mesenchymal transition via Wnt/β-catenin signaling in endometrial carcinoma

Androgen receptor regulates SRC expression through microRNA-203

Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis

Supra-complete surgery via dual intraoperative visualization approach (DiVA) prolongs patient survival in glioblastoma

Dissecting dysfunctional crosstalk pathways regulated by miRNAs during glioma progression

Treatment of newly diagnosed B-cell origin primary CNS lymphoma with systemic R-IDARAM chemotherapy and intrathecal immunochemotherapy

Long noncoding RNAs as auxiliary biomarkers for gastric cancer screening: A pooled analysis of individual studies

Twist promotes angiogenesis in pancreatic cancer by targeting miR-497/VEGFA axis

Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers

The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients

The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway

HDAC1 controls CIP2A transcription in human colorectal cancer cells

HMGA2 overexpression plays a critical role in the progression of esophageal squamous carcinoma

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair

ILNCSIM: improved lncRNA functional similarity calculation model

Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer

A preoperative mathematic model for computed tomographic guided microwave ablation treatment of hepatic dome tumors

Transcriptional regulation of the potential tumor suppressor ABI3 gene in thyroid carcinomas: interplay between methylation and NKX2-1 availability

Salidroside suppresses solar ultraviolet-induced skin inflammation by targeting cyclooxygenase-2

A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor

Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells

miR-340 and ZEB1 negative feedback loop regulates TGF-β- mediated breast cancer progression

Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3

Volatile anaesthetics enhance the metastasis related cellular signalling including CXCR2 of ovarian cancer cells

Smurf1 regulation of DAB2IP controls cell proliferation and migration

Identification of a three-miRNA signature as a blood-borne diagnostic marker for early diagnosis of lung adenocarcinoma

Prognostic value of aberrant promoter hypermethylation of tumor-related genes in early-stage head and neck cancer

Alu methylation serves as a biomarker for non-invasive diagnosis of glioma

Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer

Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death

REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling

Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression

Genetic polymorphisms of immune checkpoint proteins PD-1 and TIM-3 are associated with survival of patients with hepatitis B virus-related hepatocellular carcinoma

Xenopatients show the need for precision medicine approach to chemotherapy in ovarian cancer

Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas

Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis

Sumoylation of TCF21 downregulates the transcriptional activity of estrogen receptor-alpha

N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents

LIM domain only 2 over-expression in prostate stromal cells facilitates prostate cancer progression through paracrine of Interleukin-11

Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer

E2F1 interactions with hHR23A inhibit its degradation and promote DNA repair

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Inhibition of melanocortin 1 receptor slows melanoma growth, reduces tumor heterogeneity and increases survival

A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells

IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer

Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo

microRNA-149 targets caspase-2 in glioma progression

Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner

Peripheral lymphocyte subset variation predicts prostate cancer carbon ion radiotherapy outcomes

Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer

Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx

Analysis of disseminated tumor cells before and after platinum based chemotherapy in primary ovarian cancer. Do stem cell like cells predict prognosis?

Genetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients

FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation

Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs

MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression

Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level

Establishment of prostate cancer spheres from a prostate cancer cell line after phenethyl isothiocyanate treatment and discovery of androgen-dependent reversible differentiation between sphere and neuroendocrine cells

Salinomycin exerts anti-angiogenic and anti-tumorigenic activities by inhibiting vascular endothelial growth factor receptor 2-mediated angiogenesis

MiR-429 reverses epithelial-mesenchymal transition by restoring E-cadherin expression in bladder cancer

PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival

Dietary intake of flavonoid subclasses and risk of colorectal cancer: evidence from population studies

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6

Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis

Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer

PRG3 induces Ras-dependent oncogenic cooperation in gliomas

Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells

Analysis of tumor template from multiple compartments in a blood sample provides complementary access to peripheral tumor biomarkers

Development of a prediction model for radiosensitivity using the expression values of genes and long non-coding RNAs

Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression

Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma

Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer

Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma

Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer

Predictive and prognostic value of preoperative serum tumor markers is EGFR mutation-specific in resectable non-small-cell lung cancer

RNF4-mediated SUMOylation is essential for NDRG2 suppression of lung adenocarcinoma

Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma

The prognosis after contraindicated surgery of NSCLC patients with malignant pleural effusion (M1a) may be better than expected

Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma

Oligometastatic state predicts a favorable outcome for renal cell carcinoma patients with bone metastasis under the treatment of sunitinib

Combined gemcitabine and S-1 chemotherapy for treating unresectable hilar cholangiocarcinoma: a randomized open-label clinical trial

The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion