Oncotarget

Research Papers:

Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer

Huijun Xie, Xiaoli Ren, Sainan Xin, Xiaoliang Lan, Guifeng Lu, Yuan Lin, Shaoshan Yang, Zhicheng Zeng, Wenting Liao, Yan-Qing Ding and Li Liang _

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Oncotarget. 2016; 7:26680-26691. https://doi.org/10.18632/oncotarget.8589

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Abstract

Huijun Xie1,2,3,*, Xiaoli Ren1,2,3,*, Sainan Xin1,2,3,*, Xiaoliang Lan4, Guifeng Lu1,2,3, Yuan Lin1,2,3, Shaoshan Yang1,2,3, Zhicheng Zeng1,2,3, Wenting Liao1,2,3, Yan-Qing Ding1,2,3, Li Liang1,2,3

1Department of Pathology, Nanfang Hospital, Guangzhou, Guangdong, China

2Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China

3Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China

4Department of General Surgery, Nanfang Hospital, Guangzhou, Guangdong, China

*These authors contributed equally to this work

Correspondence to:

Li Liang, email: [email protected]

Yan-Qing Ding, email: [email protected]

Keywords: hsa_circ_001569, miR-145, colorectal cancer, FMNL2, BAG4

Received: December 08, 2015     Accepted: March 07, 2016     Published: April 05, 2016

ABSTRACT

Circular RNAs (circRNAs), a large class of RNAs, have recently shown huge capabilities as gene regulators in mammals. Some of them bind with microRNAs (miRNAs) and act as natural miRNA sponges to inhibit related miRNAs’ activities. Here we showed that hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC tissues, circ_001569 negatively correlated with miR-145, and miR-145 correlated negatively with E2F5, BAG4 and FMNL2 expressions. Our study reveals a novel regulatory mechanism of circ_001569 in cell proliferation and invasion in CRC, provides a comprehensive landscape of circ_001569 that will facilitate further biomarker discoveries in the progression of CRC.


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