miR-340 and ZEB1 negative feedback loop regulates TGF-β- mediated breast cancer progression
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Li-Kun Hou1,2,3,*, Yue Yu1,2,3,*, Ye-Gong Xie1,2,3, Jie Wang1,2,3, Jie-Fei Mao1,2,3, Bin Zhang1,2,3, Xin Wang1,2,3, Xu-Chen Cao1,2,3
1The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
2Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China
3Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China
*These authors contributed equally to this work
Xu-Chen Cao, e-mail: email@example.com
Keywords: miR-340, ZEB1, TGF-β, EMT, breast cancer
Received: October 27, 2015 Accepted: March 06, 2016 Published: March 27, 2016
MicroRNAs act as key regulators in carcinogenesis and progression in various cancers. In present study, we explored the role of miR-340 in the breast cancer progression. Our results showed that overexpression of miR-340 inhibits breast cancer cell proliferation and invasion, whereas depletion of miR-340 promotes breast cancer progression. Molecularly, ZEB1 was identified as a target gene of miR-340 and miR-340 suppressed the expression of ZEB1 by directly binding to the 3′-UTR of ZEB1. Furthermore, ZEB1 transcriptionally suppresses miR-340 expression. The negative feedback loop regulated TGF-β-mediated breast cancer progression. In conclusion, our data suggested that miR-340 acted as a tumor suppressor in breast cancer progression.
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