Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization

Valentina Polo, Giulia Pasello, Stefano Frega, Adolfo Favaretto, Haralabos Koussis, Pierfranco Conte and Laura Bonanno _

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Oncotarget. 2016; 7:25050-25063. https://doi.org/10.18632/oncotarget.7732

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Valentina Polo1,2, Giulia Pasello1, Stefano Frega1, Adolfo Favaretto1, Haralabos Koussis1, Pierfranco Conte1,2 and Laura Bonanno1

1 Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy

2 Department of Surgery, Oncology and Gastroenterology, Università degli Studi di Padova, Padova, Italy

Correspondence to:

Laura Bonanno, email:

Keywords: squamous cell carcinoma, lung, head and neck, smoke, HPV

Received: October 08, 2015 Accepted: January 29, 2016 Published: February 25, 2016


Squamous cell carcinomas of the lung and of the head and neck district share strong association with smoking habits and are characterized by smoke-related genetic alterations. Driver mutations have been identified in small percentage of lung squamous cell carcinoma. In parallel, squamous head and neck tumors are classified according to the HPV positivity, thus identifying two different clinical and molecular subgroups of disease.

This review depicts different molecular portraits and potential clinical application in the field of targeted therapy, immunotherapy and chemotherapy personalization.

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