Vol 6, No 30

A 4D view on mRNA

S-nitrosylation and MSC-mediated body composition

Type I collagen fibrils: an inducer of invadosomes

Enhancing immunity by engineering DAMPs

STAT2-directed pathogen responses

Cross-presentation of antigens by dendritic cells: role of autophagy

Protective CD8⁺ T cell memory without help

MCPIP: a key player in macrophage polarization

Defensins versus pathogens: an unfolding story

Quelling an innate response to dsRNA

DNAM-1: would the real natural killer cell please stand up!

MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties

CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2_a,b^–/– mice favoring autoimmune cholangitis

Nickel chloride (NiCl₂)-caused inflammatory responses via activation of NF-κB pathway and reduction of anti-inflammatory mediator expression in the kidney

PDGF upregulates CLEC-2 to induce T regulatory cells

Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins

A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation

Vanadium toxicity in the thymic development

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity

Timing and extent of response in colorectal cancer: critical review of current data and implication for future trials

Vav1: A Dr. Jekyll and Mr. Hyde protein – good for the hematopoietic system, bad for cancer

Triple-layer dissection of the lung adenocarcinoma transcriptome – regulation at the gene, transcript, and exon levels

New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK

The prognosis was poorer in colorectal cancers that expressed both VEGF and PROK1(No correlation coefficient between VEGF and PROK1)

Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells

FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases

Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells

MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

MiR-1207 overexpression promotes cancer stem cell–like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1

Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

Identification and characterization of RET fusions in advanced colorectal cancer

Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo

Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism

Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis

Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells

Changes in the gene expression of co-cultured human fibroblast cells and osteosarcoma cells: the role of microenvironment

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients

IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production

HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma

TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer

Suppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma

The importance of microenvironment: the role of CCL8 in metastasis formation of melanoma

miR-146b-5p functions as a tumor suppressor by targeting TRAF6 and predicts the prognosis of human gliomas

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways

Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy

Colorectal cancer-promoting activity of the senescent peritoneal mesothelium

Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin

H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b

miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations

TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma

The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study

Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis

A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients

High throughput screening of cytokines, chemokines and matrix metalloproteinases in wound fluid induced by mammary surgery

Effect of latent membrane protein 1 expression on overall survival in Epstein-Barr virus-associated cancers: a literature-based meta-analysis

Identification and characterization of ANO9 in stage II and III colorectal carcinoma

Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC)

A method for predicting target drug efficiency in cancer based on the analysis of signaling pathway activation

Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma

18F-fluorodeoxyglucose (FDG) PET/CT after two cycles of neoadjuvant therapy may predict response in HER2-negative, but not in HER2-positive breast cancer

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop

Exposure to airborne PM_2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells

TRAIL-mediated killing of acute lymphoblastic leukemia by plasmacytoid dendritic cell-activated natural killer cells

Inhibition of DNA-repair genes Ercc1 and Mgmt enhances temozolomide efficacy in gliomas treatment: a pre-clinical study

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells

Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells

Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activation

Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi

MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1

Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression

Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma

Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2^V617F cells

S100P interacts with integrin α7 and increases cancer cell migration and invasion in lung cancer

A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis

RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca²⁺/MICU1 dependent mitochondrial signaling

CAVEOLIN-1 expression in brain metastasis from lung cancer predicts worse outcome and radioresistance, irrespective of tumor histotype

Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells

Regulation and functional significance of CDC42 alternative splicing in ovarian cancer

Anti-angiogenic efficacy of 5′-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs

CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion

Differential targeting of the cyclin-dependent kinase inhibitor, p21^CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types

Heat shock factor 1, an inhibitor of non-homologous end joining repair

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma

The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H₂O₂ generation: antagonism by tetrathiomolybdate

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer

Aberrant reduction of telomere repetitive sequences in plasma cell-free DNA for early breast cancer detection

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients

Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3β and Nur77 to prevent β-catenin degradation

ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression

Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p

Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype

Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts

Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution

Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention

Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling

Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells

The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

Dissecting the contribution of EBNA3C domains important for EBV-induced B-cell growth and proliferation

Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition

Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma

RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors

Clinical impact of CD200 expression in patients with acute myeloid leukemia and correlation with other molecular prognostic factors

Histidine-rich glycoprotein function in hepatocellular carcinoma depends on its N-glycosylation status, and it regulates cell proliferation by inhibiting Erk1/2 phosphorylation

IDH1/2 mutation status combined with Ki-67 labeling index defines distinct prognostic groups in glioma

MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118

Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer

Survival outcome according to KRAS mutation status in newly diagnosed patients with stage IV non-small cell lung cancer treated with platinum doublet chemotherapy

IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas

Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial

Post-treatment plasma EBV-DNA positivity predicts early relapse and poor prognosis for patients with extranodal NK/T cell lymphoma in the era of asparaginase

Expression of high affinity folate receptor in breast cancer brain metastasis

Plasma biomarkers of clinical response during chemotherapy plus combination antiretroviral therapy (cART) in HIV+ patients with advanced Kaposi sarcoma

High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer

Identification of prostate cancer biomarkers in urinary exosomes

Implications for determining the optimal treatment for locally advanced rectal cancer in elderly patients aged 75 years and older

⁸⁹Zr-cetuximab PET imaging in patients with advanced colorectal cancer

Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer: Results of the BRANCH trial

A phase 2, open-label, multicenter study of the long-term safety of siltuximab (an anti-interleukin-6 monoclonal antibody) in patients with multicentric Castleman disease