MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

Tao Yu; Lei Liu; Jing Li; Mingxia Yan; Hechun Lin; Ying Liu; Dandan Chu; Hong Tu; Aiqin Gu; Ming Yao

doi:10.18632/oncotarget.4972

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

Tao Yu, Lei Liu, Jing Li, Mingxia Yan, Hechun Lin, Ying Liu, Dandan Chu, Hong Tu, Aiqin Gu and Ming Yao _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2015; 6:30239-30250. https://doi.org/10.18632/oncotarget.4972

Metrics: PDF 2806 views | HTML 3433 views | ?

Abstract

Tao Yu1,*, Lei Liu1,*, Jing Li1, Mingxia Yan1, Hechun Lin1, Ying Liu1, Dandan Chu1, Hong Tu1, Aiqin Gu2 and Ming Yao1

1 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2 Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

* Authors share co-first authorship

Correspondence to:

Ming Yao, email:

Aiqin Gu, email:

Keywords: NSCLC, metastasis, microRNA-10a, PTEN

Received: April 15, 2015 Accepted: July 11, 2015 Published: July 22, 2015

Abstract

MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 4972

Publication Alerts

Research Papers:

MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

Abstract