PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
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Shixian Lian1,*, Yebo Shao1,*, Houbao Liu1,*, Junyi He1,*, Weiqi Lu1, Yong Zhang1, Ying Jiang1, Jun Zhu1
1Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
*These authors have contributed equally to this work
Zhu J., e-mail: email@example.com
Keywords: 3-phosphoinositide-dependent protein kinase 1, JunB, invasion, migration, epithelial–mesenchymal transition
Received: April 20, 2015 Accepted: July 23, 2015 Published: August 05, 2015
The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial–mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.
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