VOLUME 6 (2015)
Table of Contents
Editorial
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| Cancer stemness and progression: mitochondria on the stage |
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https://doi.org/10.18632/oncotarget.6244
|
| 36924-36925 |
Editorial: Autophagy and Cell Death
Priority Research Papers
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| MDA7/IL24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer |
|
https://doi.org/10.18632/oncotarget.6047
|
| 36928-36942 |
|
| Suppression of Her2/Neu mammary tumor development in mda7/IL24 transgenic mice |
|
https://doi.org/10.18632/oncotarget.6046
|
| 36943-36954 |
Research Papers: Gerotarget (Focus on Aging)
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| Risk prediction for sporadic Alzheimer’s disease using genetic risk score in the Han Chinese population |
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https://doi.org/10.18632/oncotarget.6271
|
| 36955-36964 |
|
| Prolonged ovarian hormone deprivation alters the effects of 17βestradiol on microRNA expression in the aged female rat hypothalamus |
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https://doi.org/10.18632/oncotarget.5433
|
| 36965-36983 |
Research Papers: Pathology
|
| Treatment of renal fibrosis by rebalancing TGFβ/Smad signaling with the combination of asiatic acid and naringenin |
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https://doi.org/10.18632/oncotarget.6100
|
| 36984-36997 |
|
| Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage |
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https://doi.org/10.18632/oncotarget.6076
|
| 36998-37011 |
|
| Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling |
|
https://doi.org/10.18632/oncotarget.6115
|
| 37012-37027 |
|
| Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma |
|
https://doi.org/10.18632/oncotarget.5939
|
| 37028-37042 |
|
| Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease |
|
https://doi.org/10.18632/oncotarget.6158
|
| 37043-37053 |
|
| Regenerating isletderived protein 1 inhibits the activation of islet stellate cells isolated from diabetic mice |
|
https://doi.org/10.18632/oncotarget.6163
|
| 37054-37065 |
Research Papers: Autophagy and Cell Death
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| Sorafenibinduced defective autophagy promotes cell death by necroptosis |
|
https://doi.org/10.18632/oncotarget.5797
|
| 37066-37082 |
|
| Lithium increases proliferation of hippocampal neural stem/progenitor cells and rescues irradiationinduced cell cycle arrest in vitro |
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https://doi.org/10.18632/oncotarget.5191
|
| 37083-37097 |
Reviews
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| The different roles of selective autophagic protein degradation in mammalian cells |
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https://doi.org/10.18632/oncotarget.5776
|
| 37098-37116 |
|
| Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling |
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https://doi.org/10.18632/oncotarget.5076
|
| 37117-37134 |
|
| Caveolin1 a stressrelated oncotarget in drug resistance |
|
https://doi.org/10.18632/oncotarget.5789
|
| 37135-37150 |
|
| Tumorderived exosomes in cancer progression and treatment failure |
|
https://doi.org/10.18632/oncotarget.6022
|
| 37151-37168 |
Research Papers
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| Remarkable similarities of chromosomal rearrangements between primary human breast cancers and matched distant metastases as revealed by wholegenome sequencing |
|
https://doi.org/10.18632/oncotarget.5951
|
| 37169-37184 |
|
| Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBAinduced mouse model of breast cancer |
|
https://doi.org/10.18632/oncotarget.5953
|
| 37185-37199 |
|
| Plasma DCLK1 is a marker of hepatocellular carcinoma HCC: Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNAdependent mechanism |
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https://doi.org/10.18632/oncotarget.5808
|
| 37200-37215 |
|
| Targeting mitochondrial RNA polymerase in acute myeloid leukemia |
|
https://doi.org/10.18632/oncotarget.6129
|
| 37216-37228 |
|
| Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF00477736 |
|
https://doi.org/10.18632/oncotarget.5954
|
| 37229-37240 |
|
| miR135b suppresses tumorigenesis in glioblastoma stemlike cells impairing proliferation migration and selfrenewal |
|
https://doi.org/10.18632/oncotarget.5925
|
| 37241-37256 |
|
| Wnt2 complements Wnt/βcatenin signaling in colorectal cancer |
|
https://doi.org/10.18632/oncotarget.6133
|
| 37257-37268 |
|
| MicroRNA21 links epithelialtomesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2positive breast cancer patients |
|
https://doi.org/10.18632/oncotarget.5495
|
| 37269-37280 |
|
| Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression |
|
https://doi.org/10.18632/oncotarget.6134
|
| 37281-37299 |
|
| Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth |
|
https://doi.org/10.18632/oncotarget.5836
|
| 37300-37315 |
|
| Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis |
|
https://doi.org/10.18632/oncotarget.5686
|
| 37316-37334 |
|
| Honokiol inhibits bladder tumor growth by suppressing EZH2/miR143 axis |
|
https://doi.org/10.18632/oncotarget.6135
|
| 37335-37348 |
|
| Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC |
|
https://doi.org/10.18632/oncotarget.5736
|
| 37349-37366 |
|
| Role of cystathionine beta synthase in lipid metabolism in ovarian cancer |
|
https://doi.org/10.18632/oncotarget.5424
|
| 37367-37384 |
|
| Rescuing lymphocytes from HLAG immunosuppressive effects mediated by the tumor microenvironment |
|
https://doi.org/10.18632/oncotarget.6044
|
| 37385-37397 |
|
| Expression of IL1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.6054
|
| 37398-37409 |
|
| SMAC mimetic Debio 1143 synergizes with taxanes topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells |
|
https://doi.org/10.18632/oncotarget.6138
|
| 37410-37425 |
|
| Targeting Syndecan1 a molecule implicated in the process of vasculogenic mimicry enhances the therapeutic efficacy of the L19IL2 immunocytokine in human melanoma xenografts |
|
https://doi.org/10.18632/oncotarget.6055
|
| 37426-37442 |
|
| The regulatory mechanisms of myogenin expression in doxorubicintreated rat cardiomyocytes |
|
https://doi.org/10.18632/oncotarget.5338
|
| 37443-37457 |
|
| MicroRNA27b microRNA101 and microRNA128 inhibit angiogenesis by downregulating vascular endothelial growth factor C expression in gastric cancers |
|
https://doi.org/10.18632/oncotarget.6059
|
| 37458-37470 |
|
| Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo |
|
https://doi.org/10.18632/oncotarget.5462
|
| 37471-37485 |
|
| In vivo imaging of therapy response to a novel PanHER antibody mixture using FDG and FLT positron emission tomography |
|
https://doi.org/10.18632/oncotarget.6060
|
| 37486-37499 |
|
| Urine BLCA4 exerts potential role in detecting patients with bladder cancers: a pooled analysis of individual studies |
|
https://doi.org/10.18632/oncotarget.6061
|
| 37500-37510 |
|
| Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy |
|
https://doi.org/10.18632/oncotarget.5527
|
| 37511-37525 |
|
| Combinatorial TGFβ attenuation with paclitaxel inhibits the epithelialtomesenchymal transition and breast cancer stemlike cells |
|
https://doi.org/10.18632/oncotarget.6063
|
| 37526-37543 |
|
| Clinical value of integratedsignature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation |
|
https://doi.org/10.18632/oncotarget.6065
|
| 37544-37556 |
|
| MiR744 increases tumorigenicity of pancreatic cancer by activating Wnt/βcatenin pathway |
|
https://doi.org/10.18632/oncotarget.5317
|
| 37557-37569 |
|
| Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration invasion and proliferation of glioblastoma cells |
|
https://doi.org/10.18632/oncotarget.6066
|
| 37570-37587 |
|
| OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer |
|
https://doi.org/10.18632/oncotarget.5940
|
| 37588-37599 |
|
| Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy |
|
https://doi.org/10.18632/oncotarget.6067
|
| 37600-37612 |
|
| Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer |
|
https://doi.org/10.18632/oncotarget.6068
|
| 37613-37625 |
|
| High intensity focused ultrasound enhances antitumor immunity by inhibiting the negative regulatory effect of miR134 on CD86 in a murine melanoma model |
|
https://doi.org/10.18632/oncotarget.5285
|
| 37626-37637 |
|
| Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response |
|
https://doi.org/10.18632/oncotarget.5497
|
| 37638-37646 |
|
| Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3′shore |
|
https://doi.org/10.18632/oncotarget.6069
|
| 37647-37662 |
|
| Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes |
|
https://doi.org/10.18632/oncotarget.5438
|
| 37663-37677 |
|
| YK4279 effectively antagonizes EWSFLI1 induced leukemia in a transgenic mouse model |
|
https://doi.org/10.18632/oncotarget.5520
|
| 37678-37694 |
|
| A bladder cancer microenvironment simulation system based on a microfluidic coculture model |
|
https://doi.org/10.18632/oncotarget.6070
|
| 37695-37705 |
|
| Methionine adenosyltransferase α2 sumoylation positively regulate Bcl2 expression in human colon and liver cancer cells |
|
https://doi.org/10.18632/oncotarget.5342
|
| 37706-37723 |
|
| Ubiquitinspecific protease 12 interacting partners Uaf1 and WDR20 are potential therapeutic targets in prostate cancer |
|
https://doi.org/10.18632/oncotarget.6075
|
| 37724-37736 |
|
| Host JDP2 expression in the bone marrow contributes to metastatic spread |
|
https://doi.org/10.18632/oncotarget.5648
|
| 37737-37749 |
|
| SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer |
|
https://doi.org/10.18632/oncotarget.5647
|
| 37750-37757 |
|
| Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stemlike properties in LnCap prostate cancer cells in vitro |
|
https://doi.org/10.18632/oncotarget.5386
|
| 37758-37769 |
|
| Migrationprone glioma cells show curcumin resistance associated with enhanced expression of miR21 and invasion/antiapoptosisrelated proteins |
|
https://doi.org/10.18632/oncotarget.6092
|
| 37770-37781 |
|
| Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 Cterminus |
|
https://doi.org/10.18632/oncotarget.5622
|
| 37782-37791 |
|
| Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma |
|
https://doi.org/10.18632/oncotarget.6096
|
| 37792-37807 |
|
| miR149 represses metastasis of hepatocellular carcinoma by targeting actinregulatory proteins PPM1F |
|
https://doi.org/10.18632/oncotarget.5676
|
| 37808-37823 |
|
| Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma |
|
https://doi.org/10.18632/oncotarget.5637
|
| 37824-37835 |
|
| JNJ26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis |
|
https://doi.org/10.18632/oncotarget.6097
|
| 37836-37851 |
|
| miRNAregulated delivery of lincRNAp21 suppresses βcatenin signaling and tumorigenicity of colorectal cancer stem cells |
|
https://doi.org/10.18632/oncotarget.5635
|
| 37852-37870 |
|
| The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2α by enhancing prestrand and poststrand cleavage and inhibiting DNA religation |
|
https://doi.org/10.18632/oncotarget.5680
|
| 37871-37894 |
|
| Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma |
|
https://doi.org/10.18632/oncotarget.5634
|
| 37895-37905 |
|
| Usp22 deficiency impairs intestinal epithelial lineage specification in vivo |
|
https://doi.org/10.18632/oncotarget.5412
|
| 37906-37918 |
|
| Endosomal gene expression: a new indicator for prostate cancer patient prognosis |
|
https://doi.org/10.18632/oncotarget.6114
|
| 37919-37929 |
|
| The novel combination of dual mTOR inhibitor AZD2014 and panPIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression |
|
https://doi.org/10.18632/oncotarget.6122
|
| 37930-37947 |
|
| A combination of tyrosine kinase inhibitors crizotinib and dasatinib for the treatment of glioblastoma multiforme |
|
https://doi.org/10.18632/oncotarget.5698
|
| 37948-37964 |
|
| Lapatinib increases motility of triplenegative breast cancer cells by decreasing miRNA7 and inducing Raf1/MAPKdependent interleukin6 |
|
https://doi.org/10.18632/oncotarget.5700
|
| 37965-37978 |
|
| SNPSNP interaction analysis of NFκB signaling pathway on breast cancer survival |
|
https://doi.org/10.18632/oncotarget.4991
|
| 37979-37994 |
|
| Loss of the epigenetic mark 5Hydroxymethylcytosine correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma |
|
https://doi.org/10.18632/oncotarget.6062
|
| 37995-38004 |
|
| LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR200s in clear cell kidney carcinoma |
|
https://doi.org/10.18632/oncotarget.5357
|
| 38005-38015 |
|
| Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing |
|
https://doi.org/10.18632/oncotarget.5697
|
| 38016-38028 |
|
| Polarized cell migration induces cancer typespecific CD133/integrin/Src/Akt/GSK3β/βcatenin signaling required for maintenance of cancer stem cell properties |
|
https://doi.org/10.18632/oncotarget.5703
|
| 38029-38045 |
|
| The impact of RNA binding motif protein 4regulated splicing cascade on the progression and metabolism of colorectal cancer cells |
|
https://doi.org/10.18632/oncotarget.5710
|
| 38046-38060 |
|
| CDC25A governs proliferation and differentiation of FLT3ITD acute myeloid leukemia |
|
https://doi.org/10.18632/oncotarget.5706
|
| 38061-38078 |
|
| Bortezomibmediated downregulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells |
|
https://doi.org/10.18632/oncotarget.5752
|
| 38079-38092 |
|
| Upregulated in Hepatitis B virusassociated hepatocellular carcinoma cells miR3313p promotes proliferation of hepatocellular carcinoma cells by targeting ING5 |
|
https://doi.org/10.18632/oncotarget.5642
|
| 38093-38106 |
|
| ZNF32 protects against oxidative stressinduced apoptosis by modulating C1QBP transcription |
|
https://doi.org/10.18632/oncotarget.5646
|
| 38107-38126 |
|
| Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF1α degradation |
|
https://doi.org/10.18632/oncotarget.5511
|
| 38127-38138 |
|
| miR124 and miR506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1 |
|
https://doi.org/10.18632/oncotarget.5709
|
| 38139-38150 |
|
| Epigenetic silencing of HIC1 promotes epithelialmesenchymal transition and drives progression in esophageal squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.5832
|
| 38151-38165 |
|
| Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways |
|
https://doi.org/10.18632/oncotarget.6241
|
| 38166-38180 |
|
| Subcellular localization of PUMA regulates its proapoptotic activity in Burkitt’s lymphoma B cells |
|
https://doi.org/10.18632/oncotarget.5901
|
| 38181-38194 |
|
| Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis |
|
https://doi.org/10.18632/oncotarget.5561
|
| 38195-38209 |
|
| Increased metastasis with loss of E2F2 in Mycdriven tumors |
|
https://doi.org/10.18632/oncotarget.5690
|
| 38210-38224 |
|
| Inhibition of Lyn is a promising treatment for mantle cell lymphoma with bortezomib resistance |
|
https://doi.org/10.18632/oncotarget.5425
|
| 38225-38238 |
|
| Interplay between YB1 and IL6 promotes the metastatic phenotype in breast cancer cells |
|
https://doi.org/10.18632/oncotarget.5664
|
| 38239-38256 |
|
| Coexpression of mitosisregulating genes contributes to malignant progression and prognosis in oligodendrogliomas |
|
https://doi.org/10.18632/oncotarget.5499
|
| 38257-38269 |
|
| MicroRNA15a/161 cluster located at chromosome 13q14 is downregulated but displays different expression pattern and prognostic significance in multiple myeloma |
|
https://doi.org/10.18632/oncotarget.5681
|
| 38270-38282 |
|
| Traditional Chinese patent medicines for cancer treatment in China: a nationwide medical insurance data analysis |
|
https://doi.org/10.18632/oncotarget.5711
|
| 38283-38295 |
|
| Combining plasma EpsteinBarr virus DNA and nodal maximal standard uptake values of 18Ffluoro2deoxyDglucose positron emission tomography improved prognostic stratification to predict distant metastasis for locoregionally advanced nasopharyngeal carcinoma |
|
https://doi.org/10.18632/oncotarget.5699
|
| 38296-38307 |
|
| Etoposide enhances antitumor efficacy of MDR1driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity |
|
https://doi.org/10.18632/oncotarget.5702
|
| 38308-38326 |
Clinical Research Papers
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| Validation of a rectal cancer outcome prediction model with a cohort of Chinese patients |
|
https://doi.org/10.18632/oncotarget.5195
|
| 38327-38335 |
|
| Better survival of renal cell carcinoma in patients with inflammatory bowel disease |
|
https://doi.org/10.18632/oncotarget.5186
|
| 38336-38347 |
|
| Development and validation of a pretreatment prognostic index to predict death and lung metastases in extremity osteosarcoma |
|
https://doi.org/10.18632/oncotarget.5276
|
| 38348-38359 |
|
| The use of personalized biomarkers and liquid biopsies to monitor treatment response and disease recurrence in locally advanced rectal cancer after neoadjuvant chemoradiation |
|
https://doi.org/10.18632/oncotarget.5256
|
| 38360-38371 |
|
| Ideal number of biopsy tumor fragments for predicting HER2 status in gastric carcinoma resection specimens |
|
https://doi.org/10.18632/oncotarget.5368
|
| 38372-38380 |
|
| Treatment outcomes and late toxicities of 869 patients with nasopharyngeal carcinoma treated with definitive intensity modulated radiation therapy: new insight into the value of total dose of cisplatin and radiation boost |
|
https://doi.org/10.18632/oncotarget.5420
|
| 38381-38397 |
|
| Breastfeeding and the incidence of endometrial cancer: A metaanalysis |
|
https://doi.org/10.18632/oncotarget.5049
|
| 38398-38409 |
|
| Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.4800
|
| 38410-38420 |
|
| Distinguishing grade I meningioma from higher grade meningiomas without biopsy |
|
https://doi.org/10.18632/oncotarget.5376
|
| 38421-38428 |
|
| Concurrent radiotherapy with gefitinib in elderly patients with esophageal squamous cell carcinoma: Preliminary results of a phase II study |
|
https://doi.org/10.18632/oncotarget.5193
|
| 38429-38439 |
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