Urine BLCA-4 exerts potential role in detecting patients with bladder cancers: a pooled analysis of individual studies
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Qiliang Cai1, Yudong Wu1, Zhanjun Guo1, Rui Gong2, Yang Tang1, Kuo Yang1, Xiaodong Li3, Xuemei Guo4, Yuanjie Niu1 and Yan Zhao5
1 Department of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, China
2 Pharmaceutical Department, the Second Hospital of Tianjin Medical University, Tianjin, China
3 Department of Radiotherapy, the Second Hospital of Tianjin Medical University, Tianjin,China
4 Library of Tianjin Medical University, Tianjin Medical University, Tianjin, China
5 Tianjin Institute of Infectious Disease, the Second Hospital of Tianjin Medical University, Tianjin, China
Yan Zhao, email:
Keywords: BLCA-4, diagnostic biomarker, bladder cancer, diagnosis, meta-analysis
Received: July 16, 2015 Accepted: September 23, 2015 Published: October 09, 2015
Epidemiological studies have explored the diagnostic effect of urine BLCA-4 in bladder cancer. However, the results remain controversial. Therefore, we conducted this pooled analyses to determine the overall accuracy of urine BLCA-4 in bladder cancer. A comprehensive electronic and hand search was conducted for related literatures though several databases. QUADAS-2 was used to assess the quality of each included studies. Diagnostic parameters were calculated using Meta-Disc (version 1.4) and Stata (version 12.0) software. Nine published articles with 1,119 subjects were included. The summary estimates were: sensitivity 0.93 (95 % confidence interval [CI] = 0.90-0.95), specificity 0.97 (95% CI, 0.95-0.98), positive likelihood ratio 48.16 (95% CI, 11.77-197.01), negative likelihood ratio 0.08 (95% CI, 0.06-0.11), diagnostic odds ratio 534.03 (95% CI, 150.15-1899.31), and the AUC was 0.9607. In conclusion, urine BLCA-4 is a promising marker in diagnosing bladder cancer.
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