SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
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Jing Tian1,*, Yaping Liu1,*, Beibei Zhu2, Yao Tian1, Rong Zhong2, Wei Chen2, Xinghua Lu3, Li Zou2, Na Shen2, Jiaming Qian3, Hui Li1, Xiaoping Miao2, Li Wang1
1Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China
2State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
3Division of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
*These authors have contributed equally to this work
Li Wang, e-mail: firstname.lastname@example.org
Xiaoping Miao, e-mail: email@example.com
Keywords: pancreatic cancer, RNA splicing, genetic variants, smoking, drinking
Received: June 22, 2015 Accepted: October 05, 2015 Published: October 15, 2015
A two-stage case-control study was conducted to examine the association between six candidate U2-depedent spliceosome genes (SRSF1, SRSF2, SF3A1, SF3B1, SF1 and PRPF40B) and pancreatic cancer (PC). Subjects with one or two T alleles at rs2074733 in SF3A1 had a lower risk of PC compared to those with two C alleles in combined two populations (OR: 0.59, 95% confidence interval: 0.48–0.73, False discovery rate (FDR)-P = 1.5E-05). Moreover, the presence of the higher-risk genotype at rs2074733 plus smoking or drinking had synergic effects on PC risk. These findings illustrate that RNA splicing-related genes appear to be associated with the occurrence of PC, and show synergic interactions with smoking and drinking in the additive model. In the future, our novel findings should be further confirmed by functional studies and independent large-scale population studies.
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