The role of PI3Kγ in metabolism and macrophage activation

New insights on the regulation of INK4/ARF locus expression

Trafficking of BK channel subunits controls arterial contractility

The success of regorafenib in hepatocellular carcinoma in a world of failures. Learnings for future developments

Treating hot flushes with a neurokinin 3 receptor antagonist

PERK interacts with FLNA to regulate ER-PM contact sites

ULBPs: regulators of human lymphocyte stress recognition

Polycystins and mechanotransduction in bone

Host histone acetylation unlocks HDAC inhibitor potential

Prognostic impact of Ikaros expression in lenalidomide-treated multiple myeloma

Checkpoint inhibitor induced cardiotoxicity: managing the drawbacks of our newest agents against cancer

Targeted therapy for metastatic triple negative breast cancer: The next frontier in precision oncology

PD-1 inhibitors in endometrial cancer

Non-classical monocytes in tissue injury and cancer

A community affair in the tumor microenvironment

GRP78 autoantibodies initiate the breakdown of the blood-brain barrier in neuromyelitis optica

Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms on Listeria monocytogenes infection

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Stability of azasetron-dexamethasone mixture for chemotherapy-induced nausea and vomiting administration

Platelet function-guided modification in antiplatelet therapy after acute ischemic stroke is associated with clinical outcomes in patients with aspirin nonresponse

miR-34a expression in human breast cancer is associated with drug resistance

Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3β signaling pathway in an in vivo model of cerebral ischemia

Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes

Human fibulin-3 protein variant expresses anti-cancer effects in the malignant glioma extracellular compartment in intracranial xenograft models

Characteristics and comparison between diabetes mellitus and non-diabetes mellitus among chronic kidney disease patients: A cross-sectional study of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Transient paraproteinemia after allogeneic hematopoietic stem cell transplantation is an underexplored phenomenon associated with graft versus host disease

Viral E6/E7 oncogene and cellular hexokinase 2 expression in HPV-positive cancer cell lines

WEE1 epigenetically modulates 5-hmC levels by pY37-H2B dependent regulation of IDH2 gene expression

Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia

Prognostic nomogram for hepatocellular carcinoma in adolescent and young adult patients after hepatectomy

Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer

Circulating tumor cells: potential markers of minimal residual disease in ovarian cancer? a study of the OVCAD consortium

Lovastatin induced Kruppel like factor 2 (KLF2), Kruppel like factor 6 (KLF6) and Ras homolog family member B (RHOB) genes and preferentially led to viability reduction of Cisplatin-resistant cells

Dnmt3b knock-down in enteric precursors reveals a possible mechanism by which this de novo methyltransferase is involved in the enteric nervous system development and the onset of Hirschsprung disease

Pharmacogenetics of response to neoadjuvant paclitaxel treatment for locally advanced breast cancer

Prognostic factors in men with metastatic castration-resistant prostate cancer treated with cabazitaxel

Tetratricopeptide repeat domain 3 overexpression tends to form aggregates and inhibit ubiquitination and degradation of DNA polymerase γ

Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer

Development of a nomogram for screening of hepatitis B virus-associated hepatocellular carcinoma

Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome

Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma

Low plasma levels of miR-101 are associated with tumor progression in gastric cancer

Single nucleotide polymorphisms as prognostic and predictive biomarkers in renal cell carcinoma

TAB3 upregulates Survivin expression to promote colorectal cancer invasion and metastasis by binding to the TAK1-TRAF6 complex

Survival benefits of gastrectomy in gastric cancer patients with stage IV: a population-based study

Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket

Sodium taurocholate cotransporting polypeptide (NTCP) deficiency: Identification of a novel SLC10A1 mutation in two unrelated infants presenting with neonatal indirect hyperbilirubinemia and remarkable hypercholanemia

GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer

Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner

BTK blocks the inhibitory effects of MDM2 on p53 activity

Long noncoding RNA MALAT1 promotes cell proliferation through suppressing miR-205 and promoting SMAD4 expression in osteosarcoma

Exacerbation of diabetic cardiac hypertrophy in OVE26 mice by angiotensin II is associated with JNK/c-Jun/miR-221-mediated autophagy inhibition

Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin

Detection of EGFR and KRAS gene mutations using suspension liquid-based cytology specimens in metastatic lung adenocarcinoma

Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcome

Bottom-up synthesis of ultra-small molybdenum disulfide-polyvinylpyrrolidone nanosheets for imaging-guided tumor regression

Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models

Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis

The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect

Estrogen metabolism in the human lung: impact of tumorigenesis, smoke, sex and race/ethnicity

Upregulation of miR-126-3p promotes human saphenous vein endothelial cell proliferation in vitro and prevents vein graft neointimal formation ex vivo and in vivo

Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome

Oridonin synergistically enhances JQ1-triggered apoptosis in hepatocellular cancer cells through mitochondrial pathway

MicroRNA-34c acts as a bidirectional switch in the maturation of insulin-producing cells derived from mesenchymal stem cells

Radiotherapy as an alternative treatment option for primary central nervous system lymphoma patients who are noncandidates for chemotherapy

Effectiveness of adjuvant systemic chemotherapy for intermediate-risk stage IB cervical cancer

The role of talin2 in breast cancer tumorigenesis and metastasis

Targeting G-protein coupled receptor-related signaling pathway in a murine xenograft model of appendiceal pseudomyxoma peritonei

Detection of somatic variants and EGFR mutations in cell-free DNA from non-small cell lung cancer patients by ultra-deep sequencing using the ion ampliseq cancer hotspot panel and droplet digital polymerase chain reaction

Impact of neoadjuvant and adjuvant radiotherapy on disease-specific survival in patients with stages II–IV rectal cancer

Effects of CCR5 59029G/A polymorphism on the risk to diabetic nephropathy

Successful identification of a predictive biomarker for lymph node metastasis in colorectal cancer using a proteomic approach

Mutations in the DNA methylation pathway and number of driver mutations predict response to azacitidine in myelodysplastic syndromes

Pseudogenes of annexin A2, novel prognosis biomarkers for diffuse gliomas

Whole exome sequencing identifies novel mutation in eight Chinese children with isolated tetralogy of Fallot

Proteomic profiling of endometrioid endometrial cancer reveals differential expression of hormone receptors and MAPK signaling proteins in obese versus non-obese patients

The application of PRECIS-2 ratings in randomized controlled trials of Chinese herbal medicine

Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched-chain amino acid ratios

Upfront treatment with the first and second-generation tyrosine kinase inhibitors in Ph-positive acute lymphoblastic leukemia

MiR-93-5p enhances growth and angiogenesis capacity of HUVECs by down-regulating EPLIN

Silencing RIF1 decreases cell growth, migration and increases cisplatin sensitivity of human cervical cancer cells

Transferrin receptor 1 upregulation in primary tumor and downregulation in benign kidney is associated with progression and mortality in renal cell carcinoma patients

Alisertib promotes apoptosis and autophagy in melanoma through p38 MAPK-mediated aurora a signaling

Surgery combined with adenoviral p53 gene therapy for treatment of non-small cell lung cancer: a phase II study

Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma

Dietary miR-451 protects erythroid cells from oxidative stress via increasing the activity of Foxo3 pathway

Circular RNA hsa_circ_0021001 in peripheral blood: a potential novel biomarker in the screening of intracranial aneurysm

miR-1271 inhibits ERα expression and confers letrozole resistance in breast cancer

Serum fetuin A level is associated with nonalcoholic fatty liver disease in Chinese population

Insulin-like growth factor-I induces chemoresistence to docetaxel by inhibiting miR-143 in human prostate cancer

About miRNAs, miRNA seeds, target genes and target pathways

Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?

NFE2L2/NRF2 silencing-inducible miR-206 targets c-MET/EGFR and suppresses BCRP/ABCG2 in cancer cells

Combined venetoclax and alvocidib in acute myeloid leukemia

Prognostic value of microRNAs in hepatocellular carcinoma: a meta-analysis

Can Kushen injection combined with TACE improve therapeutic efficacy and safety in patients with advanced HCC? a systematic review and network meta-analysis

Five zinc finger protein 350 single nucleotide polymorphisms and the risks of breast cancer: a meta-analysis

Safety and efficacy of ferric citrate in phosphate reduction and iron supplementation in patients with chronic kidney disease

Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: a meta-analysis

Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data

Monitoring neoadjuvant therapy responses in rectal cancer using multimodal nonlinear optical microscopy