Bottom-up synthesis of ultra-small molybdenum disulfide-polyvinylpyrrolidone nanosheets for imaging-guided tumor regression
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Jiulong Zhao1,*, Chunhua Zhou1,2,*, Mao Li1,*, Jialing Li1, Guixiang Li1, Dan Ma1, Zhaoshen Li1 and Duowu Zou1
1Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
*These authors have contributed equally to this work
Duowu Zou, email: [email protected]
Keywords: molybdenum disulfide; ultra-small; bottom-up; cell nucleus; photothermal therapy
Received: June 27, 2017 Accepted: August 27, 2017 Published: November 08, 2017
The two-dimensional molybdenum disulfide (MoS2) nanosheet has been extensively studied as a novel photothermal transducing agent. However, top-down exfoliation to produce MoS2 nanosheets is inefficient, and MoS2 nanosheet surface modification procedures are complex. Here, we report the synchronous synthesis and surface modification of 2D MoS2 nanosheets with a polyvinylpyrrolidone (PVP)-assisted one-pot hydrothermal method. Due to the chelating-coordinating effect between the lone-pair electrons of the PVP carbonyl oxygen and the unoccupied 4d orbitals of molybdenum, the PVP chains could graft onto the surface of MoS2 and guide the growth of the nanosheets. The resultant MoS2-PVP nanosheets were ultra-small (21.4 ± 4.4 nm) and exhibited excellent colloidal stability. Moreover, the strong near-infrared absorption of the MoS2-PVP nanosheets enabled sensitive photothermal conversion performance (with a mass extinction coefficient of 23.33 L g−1 cm−1) and in vitro/in vivo photoacoustic imaging. The MoS2-PVP nanosheets had excellent in vitro and in vivo compatibility and were used for highly efficient tumor photothermal therapy in xenograft tumor-bearing mice. The findings in this report will facilitate the rational design of stable colloidal 2D transition-metal dichalcogenides for effective photothermal cancer therapy.
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