Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: a meta-analysis

Jianping Xiong, Haoaohai Zhang, Yaqin Wang, Anqiang Wang, Jin Bian, Hanchun Huang, Ying Zheng, Xinting Sang, Yiyao Xu _, Xin Lu and Haitao Zhao

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Oncotarget. 2017; 8:107295-107302. https://doi.org/10.18632/oncotarget.22364

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Jianping Xiong1,*, Haoaohai Zhang1,*, Yaqin Wang2, Anqiang Wang1, Jin Bian1, Hanchun Huang1, Ying Zheng3, Xinting Sang 1, Yiyao Xu1, Xin Lu1 and Haitao Zhao1

1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

2Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China

3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau SAR, China

*These authors contributed equally to this work

Correspondence to:

Yiyao Xu, email: [email protected]

Xin Lu, email: [email protected]

Haitao Zhao, email: [email protected]

Keywords: hepatitis B Virus, nonalcoholic fatty liver disease, meta-analysis

Received: April 04, 2017     Accepted: September 04, 2017     Published: November 03, 2017


Some studies have reported that hepatitis B virus (HBV) infection affects the risk of nonalcoholic fatty liver disease (NAFLD). However, this association is controversial. We conducted a systematic review and meta-analysis to investigate the relationship between HBV infection and NAFLD. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. We used the random-effects model proposed by DerSimonian and Laird to quantify the relationship between HBV infection and risk of NAFLD. We also conducted subgroup and sensitivity analyses to validate the stability of the results. Five articles, comprising 8,272 HBV-infected patients and 111,631 uninfected controls, were included in our research. Our meta-analysis suggested that the risk of NAFLD was significantly lower in HBV-infected patients than in uninfected controls, with heterogeneity between studies (summary odds ratio [OR] = 0.71; confidence interval [CI] = 0.53–0.90; I2 = 75.2%). However, the inverse relationship was observed in only cohort (OR = 0.83; 95% CI = 0.73–0.94) and cross-sectional studies (OR = 0.63; 95% CI = 0.47–0.79), not case-control studies (OR = 3.96; 95% CI = 2.10–7.48). In conclusion, HBV infection was inversely associated with the risk of NAFLD.

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