Research Papers:

Characteristics and comparison between diabetes mellitus and non-diabetes mellitus among chronic kidney disease patients: A cross-sectional study of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Jun-Jun Zhang, Liu Yang, Jun-Wen Huang, Yu-Jie Liu, Jin-Wei Wang, Lu-Xia Zhang, Ming-Hui Zhao and Zhang-Suo Liu _

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Oncotarget. 2017; 8:106324-106332. https://doi.org/10.18632/oncotarget.22368

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Jun-Jun Zhang1,2,*, Liu Yang1,2,*, Jun-Wen Huang1,2, Yu-Jie Liu3, Jin-Wei Wang4, Lu-Xia Zhang4, Ming-Hui Zhao4 and Zhang-Suo Liu1,2

1Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

2Research Institute of Nephropathy, Zhengzhou University, Zhengzhou, Henan, China

3Department of Nephrology and Rheumatology, Children’s Hospital of Zhengzhou City, Zhengzhou, Henan, China

4Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China

*These authors contributed equally to this work

Correspondence to:

Zhang-Suo Liu, email: [email protected]

Keywords: chronic kidney disease; diabetes mellitus; clinical traits; medication; diabetic nephropathy

Received: March 02, 2017     Accepted: October 13, 2017     Published: November 10, 2017


Although the prevalence of chronic kidney disease (CKD) and diabetes mellitus (DM) is increasing globally, information on Chinese CKD patients with DM is lacking. A total of 3499 pre-dialysis CKD patients from across China were enrolled in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) between November 2011 and April 2016. We divided the C-STRIDE patients into CKD with DM and CKD without DM groups and compared their clinical, demographic, and laboratory data in this cross-sectional study. CKD patients with DM were older, had a higher male-to-female ratio, and had more complications than CKD patients without DM. Age, smoking, and 24-h urinary protein levels were associated with co-occurrence of CKD and DM. Less than 50% of patients in either group took antilipemic, cardiovascular, cerebrovascular, or anti-anemic drugs. In addition, only 18.38% of CKD patients with DM had undergone a renal biopsy, and diabetic nephropathy was confirmed in 35.4% of them. Our findings suggest that several types of medication and renal biopsies should be used more frequently in the treatment of Chinese CKD patients with DM.

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