ICOS regulates ILC2s in asthma

ULK1 in type I interferon response

RSK-c-Fos in KSHV lytic progression

Clearance of dying cells accelerates malignancy

Gli2, hedgehog and TCR signalling

Progenitor cell fate, SOXC and WNT

Putting the brakes on chondrosarcoma

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

Age-related somatic mutations in the cancer genome

Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways

Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids

N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy

ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy

New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas

A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

A measles virus selectively blind to signaling lymphocytic activation molecule shows anti-tumor activity against lung cancer cells

Continuation of epidermal growth factor receptor tyrosine kinase inhibitor treatment prolongs disease control in non-small-cell lung cancers with acquired resistance to EGFR tyrosine kinase inhibitors

Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer

Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity

MDA5 complements TLR3 in suppression of neuroblastoma

An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer

Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model

Local production of the chemokines CCL5 and CXCL10 attracts CD8⁺ T lymphocytes into esophageal squamous cell carcinoma

Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens

Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer

Detection of soluble EpCAM (sEpCAM) in malignant ascites predicts poor overall survival in patients treated with catumaxomab

MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma

Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl

A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer

Hepatitis B virus-associated diffuse large B-cell lymphoma: unique clinical features, poor outcome, and hepatitis B surface antigen-driven origin

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid

Hepatocellular carcinoma associated microRNA expression signature: integrated bioinformatics analysis, experimental validation and clinical significance

Association between TERT promoter polymorphisms and acute myeloid leukemia risk and prognosis

Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)

An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 element

LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation

Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics

Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion

Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death

MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3

RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions

Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186

CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer

Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer

A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancer

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2

MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer

Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature

eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27^Kip1 translation

Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures

Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma

Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas

Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines

Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

Inhibition of ERRα suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

Patient-derived cell models as preclinical tools for genome-directed targeted therapy

Genomic landscape of salivary gland tumors

Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK

A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

The BIM deletion polymorphism is a prognostic biomarker of EGFR-TKIs response in NSCLC: A systematic review and meta-analysis

NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway

Reduced rate of copy number aberrations in mucinous colorectal carcinoma

TNF signaling mediates an enzalutamide-induced metastatic phenotype of prostate cancer and microenvironment cell co-cultures

Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways

Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D₃

Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition

SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients

Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative

KMT Set7/9 affects genotoxic stress response via the Mdm2 axis

CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration

Analysis of SDHD promoter mutations in various types of melanoma

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma

Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway

Curcumin combined with FAPαc vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-α in melanoma

Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics

miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin

5-hydroxytryptamine receptor (5-HT_1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway

Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression

Metabolic alterations caused by HNF1β expression in ovarian clear cell carcinoma contribute to cell survival

Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy

ZIP4 silencing improves bone loss in pancreatic cancer

Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation

Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals

Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status

Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias

Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1

Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression

Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells

Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells

MicroRNA-494 inhibits cell proliferation and invasion of chondrosarcoma cells in vivo and in vitro by directly targeting SOX9

OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo

Prokineticin 2 (PROK2) is an important factor for angiogenesis in colorectal cancer

Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients

GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway

CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination

An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy

Identification of GALNT14 as a novel neuroblastoma predisposition gene

IKK inhibition increases bortezomib effectiveness in ovarian cancer

Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC

AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma

The sum of gains and losses of genes encoding the protein tyrosine kinase targets predicts response to multi-kinase inhibitor treatment: Characterization, validation, and prognostic value

Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model

A genome-wide assessment of rare copy number variants in colorectal cancer

MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model

Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer

MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1

Evaluating blood levels of neuron specific enolase, chromogranin A, and circulating tumor cells as Merkel cell carcinoma biomarkers

Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer

SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway

Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma

Host genotype and tumor phenotype of chemokine decoy receptors integrally affect breast cancer relapse

Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation