Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
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Desheng Xiao1, Jiantao Jia2, Ying Shi2,3,4, Chunyan Fu1, Ling Chen2,3,4, Yiqun Jiang2,3,4, Li Zhou1, Shuang Liu5, Yongguang Tao2,3,4
1Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China
2Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China
3Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Hunan, 410078, China
4Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Hunan, 410078, China
5Center for Medicine Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
Yongguang Tao, e-mail: [email protected]
Shuang Liu, e-mail: [email protected]
Keywords: IKKα, keratinizing cancer, non-keratinizing cancer
Received: March 17, 2015 Accepted: July 24, 2015 Published: August 06, 2015
The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlateed with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer.
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