Vol 6, No 27

How to wake a giant

Hyperinflammation, T cells, and endotoxemia

Casp8p41 and HIV

Targeting brain estrogen receptor for binge eating

Protection of muscle nuclei

HMGB1 and injury amplification

Non-coding RNAs including miRNAs, piRNAs, and tRNAs in human cancer

Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma

Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells

The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy

Conditional survival estimate of acute-on-chronic hepatitis B liver failure: a dynamic prediction based on a multicenter cohort

Na⁺-induced Ca²⁺ influx through reverse mode of Na⁺-Ca²⁺ exchanger in mouse ventricular cardiomyocyte

AXL is an oncotarget in human colorectal cancer

Mouse models of liver cancer: Progress and recommendations

MicroRNA in pancreatic adenocarcinoma: predictive/prognostic biomarkers or therapeutic targets?

Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents

TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma

Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation

High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer

Spatiotemporal control of gene expression in bone-marrow derived cells of the tumor microenvironment induced by MRI guided focused ultrasound

The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination

miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma

Embigin, regulated by HOXC8, plays a suppressive role in breast tumorigenesis

Cisplatin inhibits MEK1/2

pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth

miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2

Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer

Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis

Time-course gene profiling and networks in demethylated retinoblastoma cell line

TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance

Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging

COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization

Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer

3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling

MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4

Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma

LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer

Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells

Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling

Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

miR-200c dampens cancer cell migration via regulation of protein kinase A subunits

NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription

Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type?

Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines

Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells

Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas

MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway

Epi-reevesioside F inhibits Na⁺/K⁺-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread

Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210

DNMT1-dependent suppression of microRNA424 regulates tumor progression in human bladder cancer

Upregulation of FAM83D affects the proliferation and invasion of hepatocellular carcinoma

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism

TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

Suppression of Rituximab-resistant B-cell lymphoma with a novel multi-component anti-CD20 mAb nanocluster

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation

Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior

Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression

Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents

EBV-encoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma

The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells

Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme

CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer

eIF3 controls cell size independently of S6K1-activity

Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions

Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology

Human stromal cells are required for an anti-breast cancer effect of zoledronic acid

miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR

Identification of miR-215 mediated targets/pathways via translational immunoprecipitation expression analysis (TrIP-chip)

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay

Distant metastasis risk and patterns of nasopharyngeal carcinoma in the era of IMRT: long-term results and benefits of chemotherapy

Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery

Optimal drug regimens for primary biliary cirrhosis: a systematic review and network meta-analysis

Sorafenib continuation or discontinuation in patients with unresectable hepatocellular carcinoma after a complete response

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

Reproductive factors and hormone receptor status among very young (<35 years) breast cancer patients