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See Duan et al. MHM, S4, and X2 cells were treated with vehicle (NT) or Nutlin (10 µM) for 24 hours. The cells were analyzed by a transmission microscope to visualize autophagic vacuoles (AVs). Representative images of early autophagic vacuoles (Avi, open arrow) and late autophagic vacuoles (Avd, filled arrow) were indicated.
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Table of Contents
Editorial
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| HIF2a inhibitors for the treatment of VHL disease |
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https://doi.org/10.18632/oncotarget.4564
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| 23036-23037 |
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| Hyperinflammation T cells and endotoxemia |
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https://doi.org/10.18632/oncotarget.5236
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| 23040-23041 |
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| Targeting brain estrogen receptor for binge eating |
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https://doi.org/10.18632/oncotarget.5239
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| 23044-23045 |
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| Protection of muscle nuclei |
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https://doi.org/10.18632/oncotarget.5240
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| 23046-23047 |
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| HMGB1 and injury amplification |
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https://doi.org/10.18632/oncotarget.5243
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| 23048-23049 |
Editorial: Gerotarget (Focus on Aging)
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| Rapid and simple detection of gerosuppressive agents |
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https://doi.org/10.18632/oncotarget.5455
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| 23050-23051 |
Research Perspectives
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| Dual mTORC1/C2 inhibitors: gerosuppressors with potential antiaging effect |
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https://doi.org/10.18632/oncotarget.5563
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| 23052-23054 |
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| Noncoding RNAs including miRNAs piRNAs and tRNAs in human cancer |
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https://doi.org/10.18632/oncotarget.5048
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| 23055-23057 |
Priority Reviews
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| Regulation of Bim in Health and Disease |
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https://doi.org/10.18632/oncotarget.5492
|
| 23058-23134 |
Priority Research Papers
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| p53regulated autophagy is controlled by glycolysis and determines cell fate |
|
https://doi.org/10.18632/oncotarget.5218
|
| 23135-23156 |
|
| Prognostic impact of cRel nuclear expression and REL amplification and crosstalk between cRel and the p53 pathway in diffuse large Bcell lymphoma |
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https://doi.org/10.18632/oncotarget.4319
|
| 23157-23180 |
Research Papers: Gerotarget (Focus on Aging)
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| Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to agerelated cognitive decline |
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https://doi.org/10.18632/oncotarget.4036
|
| 23181-23203 |
|
| Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells |
|
https://doi.org/10.18632/oncotarget.4673
|
| 23204-23212 |
|
| The effects of graded levels of calorie restriction: II Impact of short term calorie and protein restriction on circulating hormone levels glucose homeostasis and oxidative stress in male C57BL/6 mice |
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https://doi.org/10.18632/oncotarget.4003
|
| 23213-23237 |
Research Papers: Pathology
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| Dual mTORC1/C2 inhibitors suppress cellular geroconversion a senescence program |
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https://doi.org/10.18632/oncotarget.4836
|
| 23238-23248 |
|
| Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy |
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https://doi.org/10.18632/oncotarget.4021
|
| 23249-23260 |
|
| Conditional survival estimate of acuteonchronic hepatitis B liver failure: a dynamic prediction based on a multicenter cohort |
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https://doi.org/10.18632/oncotarget.4666
|
| 23261-23271 |
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| Na+induced Ca2+ influx through reverse mode of Na+Ca2+ exchanger in mouse ventricular cardiomyocyte |
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https://doi.org/10.18632/oncotarget.4878
|
| 23272-23280 |
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| AXL is an oncotarget in human colorectal cancer |
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https://doi.org/10.18632/oncotarget.3962
|
| 23281-23296 |
Reviews
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| The role of MicroRNAs expression in laryngeal cancer |
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https://doi.org/10.18632/oncotarget.4195
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| 23297-23305 |
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| Mouse models of liver cancer: Progress and recommendations |
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https://doi.org/10.18632/oncotarget.4202
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| 23306-23322 |
|
| MicroRNA in pancreatic adenocarcinoma: predictive/prognostic biomarkers or therapeutic targets |
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https://doi.org/10.18632/oncotarget.4492
|
| 23323-23341 |
Research Papers
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| Long noncoding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelialmesenchymal transition |
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https://doi.org/10.18632/oncotarget.4344
|
| 23342-23357 |
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| Androgen receptor splice variants circumvent AR blockade by microtubuletargeting agents |
|
https://doi.org/10.18632/oncotarget.4396
|
| 23358-23371 |
|
| TET family proteins and 5hydroxymethylcytosine in esophageal squamous cell carcinoma |
|
https://doi.org/10.18632/oncotarget.4281
|
| 23372-23382 |
|
| Extracellularly secreted APE1/Ref1 triggers apoptosis in triplenegative breast cancer cells via RAGE binding which is mediated through acetylation |
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https://doi.org/10.18632/oncotarget.4345
|
| 23383-23398 |
|
| High copy number variation of cancerrelated microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer |
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https://doi.org/10.18632/oncotarget.4351
|
| 23399-23416 |
|
| Spatiotemporal control of gene expression in bonemarrow derived cells of the tumor microenvironment induced by MRI guided focused ultrasound |
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https://doi.org/10.18632/oncotarget.4288
|
| 23417-23426 |
|
| The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition |
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https://doi.org/10.18632/oncotarget.4370
|
| 23427-23444 |
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| Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer |
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https://doi.org/10.18632/oncotarget.4352
|
| 23445-23461 |
|
| A pancreatic tumorspecific biomarker characterized in humans and mice as an immunogenic oncoglycoprotein is efficient in dendritic cell vaccination |
|
https://doi.org/10.18632/oncotarget.4359
|
| 23462-23479 |
|
| miR193a3p is a potential tumor suppressor in malignant pleural mesothelioma |
|
https://doi.org/10.18632/oncotarget.4346
|
| 23480-23495 |
|
| Embigin regulated by HOXC8 plays a suppressive role in breast tumorigenesis |
|
https://doi.org/10.18632/oncotarget.4360
|
| 23496-23509 |
|
| pHLIPmediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth |
|
https://doi.org/10.18632/oncotarget.4395
|
| 23523-23532 |
|
| miR93/miR106b/miR375CICCRABP1: a novel regulatory axis in prostate cancer progression |
|
https://doi.org/10.18632/oncotarget.4372
|
| 23533-23547 |
|
| Hyperglycemiainduced metabolic compensation inhibits metformin sensitivity in ovarian cancer |
|
https://doi.org/10.18632/oncotarget.4556
|
| 23548-23560 |
|
| A plant alkaloid veratridine potentiates cancer chemosensitivity by UBXN2Adependent inhibition of an oncoprotein mortalin2 |
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https://doi.org/10.18632/oncotarget.4452
|
| 23561-23581 |
|
| Long noncoding RNA UCA1 induces nonT790M acquired resistance to EGFRTKIs by activating the AKT/mTOR pathway in EGFRmutant nonsmall cell lung cancer |
|
https://doi.org/10.18632/oncotarget.4361
|
| 23582-23593 |
|
| Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma |
|
https://doi.org/10.18632/oncotarget.4335
|
| 23594-23608 |
|
| The IMiDs targets IKZF1/3 and IRF4 as novel negative regulators of NK cellactivating ligands expression in multiple myeloma |
|
https://doi.org/10.18632/oncotarget.4603
|
| 23609-23630 |
|
| A NOX2/Egr1/Fyn pathway delineates new targets for TKIresistant malignancies |
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https://doi.org/10.18632/oncotarget.4604
|
| 23631-23646 |
|
| Gliomaderived plasminogen activator inhibitor1 PAI1 regulates the recruitment of LRP1 positive mast cells |
|
https://doi.org/10.18632/oncotarget.4640
|
| 23647-23661 |
|
| CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models |
|
https://doi.org/10.18632/oncotarget.4282
|
| 23662-23670 |
|
| Chemically modified nonanticoagulant heparin derivatives are potent galectin3 binding inhibitors and inhibit circulating galectin3promoted metastasis |
|
https://doi.org/10.18632/oncotarget.4409
|
| 23671-23687 |
|
| Timecourse gene profiling and networks in demethylated retinoblastoma cell line |
|
https://doi.org/10.18632/oncotarget.4644
|
| 23688-23707 |
|
| TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome |
|
https://doi.org/10.18632/oncotarget.4291
|
| 23708-23719 |
|
| Critical role of Wnt/βcatenin signaling in driving epithelial ovarian cancer platinum resistance |
|
https://doi.org/10.18632/oncotarget.4690
|
| 23720-23734 |
|
| Retargeted human avidinCAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging |
|
https://doi.org/10.18632/oncotarget.4362
|
| 23735-23747 |
|
| COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization |
|
https://doi.org/10.18632/oncotarget.4250
|
| 23748-23763 |
|
| Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer |
|
https://doi.org/10.18632/oncotarget.4350
|
| 23764-23775 |
|
| 3'3Diindolylmethane inhibits migration invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling |
|
https://doi.org/10.18632/oncotarget.4196
|
| 23776-23792 |
|
| MiR26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4 |
|
https://doi.org/10.18632/oncotarget.4363
|
| 23793-23806 |
|
| Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.4278
|
| 23807-23819 |
|
| LINE1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer |
|
https://doi.org/10.18632/oncotarget.4450
|
| 23820-23836 |
|
| Direct regulation of Ecadherin by targeted histone methylation of TALESET fusion protein in cancer cells |
|
https://doi.org/10.18632/oncotarget.4340
|
| 23837-23844 |
|
| Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling |
|
https://doi.org/10.18632/oncotarget.4313
|
| 23845-23856 |
|
| Lovastatin overcomes gefitinib resistance through TNFα signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo |
|
https://doi.org/10.18632/oncotarget.4408
|
| 23857-23873 |
|
| miR200c dampens cancer cell migration via regulation of protein kinase A subunits |
|
https://doi.org/10.18632/oncotarget.4381
|
| 23874-23889 |
|
| NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α and AP1mediated VEGFa transcription |
|
https://doi.org/10.18632/oncotarget.4341
|
| 23890-23904 |
|
| Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type |
|
https://doi.org/10.18632/oncotarget.4163
|
| 23905-23916 |
|
| Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1 ornithine decarboxylase and antizyme inhibitor |
|
https://doi.org/10.18632/oncotarget.4469
|
| 23917-23929 |
|
| E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines |
|
https://doi.org/10.18632/oncotarget.4525
|
| 23930-23943 |
|
| Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis |
|
https://doi.org/10.18632/oncotarget.4062
|
| 23944-23958 |
|
| Systematic dissection of phenotypic functional and tumorigenic heterogeneity of human prostate cancer cells |
|
https://doi.org/10.18632/oncotarget.4260
|
| 23959-23986 |
|
| Targeting chemotherapyinduced PTX3 in tumor stroma to prevent the progression of drugresistant cancers |
|
https://doi.org/10.18632/oncotarget.4364
|
| 23987-24001 |
|
| Activation of microRNA494targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas |
|
https://doi.org/10.18632/oncotarget.4365
|
| 24002-24016 |
|
| MicroRNA7 inhibits the stemness of prostate cancer stemlike cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway |
|
https://doi.org/10.18632/oncotarget.4447
|
| 24017-24031 |
|
| Epireevesioside F inhibits Na+/K+ATPase causing cytosolic acidification Bak activation and apoptosis in glioblastoma |
|
https://doi.org/10.18632/oncotarget.4429
|
| 24032-24046 |
|
| Humanized antihepatocyte growth factor HGF antibody suppresses innate irinotecan CPT11 resistance induced by fibroblastderived HGF |
|
https://doi.org/10.18632/oncotarget.4369
|
| 24047-24060 |
|
| Targeting stromalinduced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread |
|
https://doi.org/10.18632/oncotarget.4448
|
| 24061-24074 |
|
| Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells |
|
https://doi.org/10.18632/oncotarget.4373
|
| 24075-24091 |
|
| eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer |
|
https://doi.org/10.18632/oncotarget.4483
|
| 24092-24104 |
|
| Oxidized lowdensity lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA210 |
|
https://doi.org/10.18632/oncotarget.4152
|
| 24105-24118 |
|
| DNMT1dependent suppression of microRNA424 regulates tumor progression in human bladder cancer |
|
https://doi.org/10.18632/oncotarget.4431
|
| 24119-24131 |
|
| Upregulation of FAM83D affects the proliferation and invasion of hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.4432
|
| 24132-24147 |
|
| Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism |
|
https://doi.org/10.18632/oncotarget.4376
|
| 24148-24162 |
|
| TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma |
|
https://doi.org/10.18632/oncotarget.4643
|
| 24163-24177 |
|
| Exposure to ALSFTDCSF generates TDP43 aggregates in glioblastoma cells through exosomes and TNTslike structure |
|
https://doi.org/10.18632/oncotarget.4680
|
| 24178-24191 |
|
| Suppression of Rituximabresistant Bcell lymphoma with a novel multicomponent antiCD20 mAb nanocluster |
|
https://doi.org/10.18632/oncotarget.4206
|
| 24192-24204 |
|
| Molecular spectrum of BRAF NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEKERK pathway activation |
|
https://doi.org/10.18632/oncotarget.4434
|
| 24205-24217 |
|
| Chemokines CCL2 3 14 stimulate macrophage bone marrow homing proliferation and polarization in multiple myeloma |
|
https://doi.org/10.18632/oncotarget.4523
|
| 24218-24229 |
|
| The downregulation of ΔNp63 in p53deficient mouse epidermal tumors favors metastatic behavior |
|
https://doi.org/10.18632/oncotarget.4353
|
| 24230-24245 |
|
| Ceramides promote apoptosis for virusinfected lymphoma cells through induction of ceramide synthases and viral lytic gene expression |
|
https://doi.org/10.18632/oncotarget.4759
|
| 24246-24260 |
|
| Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis |
|
https://doi.org/10.18632/oncotarget.4637
|
| 24261-24276 |
|
| Semisynthetic ocotillol analogues as selective ABCB1mediated drug resistance reversal agents |
|
https://doi.org/10.18632/oncotarget.4493
|
| 24277-24290 |
|
| EBVencoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma |
|
https://doi.org/10.18632/oncotarget.4552
|
| 24291-24303 |
|
| The antidiabetic compound 2dodecyl6methoxycyclohexa25diene14dione isolated from averrhoa carambola L demonstrates significant antitumor potential against human breast cancer cells |
|
https://doi.org/10.18632/oncotarget.4475
|
| 24304-24319 |
|
| Detection of novel and potentially actionable anaplastic lymphoma kinase ALK rearrangement in colorectal adenocarcinoma by immunohistochemistry screening |
|
https://doi.org/10.18632/oncotarget.4462
|
| 24320-24332 |
|
| 5mChydroxylase activity is influenced by the PARylation of TET1 enzyme |
|
https://doi.org/10.18632/oncotarget.4476
|
| 24333-24347 |
|
| CCR7 enhances TGFβ1induced epithelialmesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer |
|
https://doi.org/10.18632/oncotarget.4484
|
| 24348-24360 |
|
| eIF3 controls cell size independently of S6K1activity |
|
https://doi.org/10.18632/oncotarget.4458
|
| 24361-24375 |
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| Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer |
|
https://doi.org/10.18632/oncotarget.4463
|
| 24376-24392 |
|
| Heme oxygenase1 accelerates erastininduced ferroptotic cell death |
|
https://doi.org/10.18632/oncotarget.5162
|
| 24393-24403 |
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| Endothelial Jagged1 promotes solid tumor growth through both proangiogenic and angiocrine functions |
|
https://doi.org/10.18632/oncotarget.4380
|
| 24404-24423 |
|
| Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesisgenomewide analysis using RNAseq technology |
|
https://doi.org/10.18632/oncotarget.4420
|
| 24424-24435 |
|
| Human stromal cells are required for an antibreast cancer effect of zoledronic acid |
|
https://doi.org/10.18632/oncotarget.4421
|
| 24436-24447 |
|
| miRNA99b5p suppresses liver metastasis of colorectal cancer by downregulating mTOR |
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https://doi.org/10.18632/oncotarget.4423
|
| 24448-24462 |
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| Identification of miR215 mediated targets/pathways via translational immunoprecipitation expression analysis TrIPchip |
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https://doi.org/10.18632/oncotarget.4425
|
| 24463-24473 |
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| Gastric cancer associated variant of DNA polymerase beta Leu22Pro promotes DNA replication associated double strand breaks |
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https://doi.org/10.18632/oncotarget.4426
|
| 24474-24487 |
Clinical Research Papers
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| Morphological and immunohistochemical identification of epithelialtomesenchymal transition in clinical prostate cancer |
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https://doi.org/10.18632/oncotarget.4177
|
| 24488-24498 |
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| Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay |
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https://doi.org/10.18632/oncotarget.4119
|
| 24499-24510 |
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| Distant metastasis risk and patterns of nasopharyngeal carcinoma in the era of IMRT: longterm results and benefits of chemotherapy |
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https://doi.org/10.18632/oncotarget.4312
|
| 24511-24521 |
|
| Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery |
|
https://doi.org/10.18632/oncotarget.4083
|
| 24522-24532 |
|
| Optimal drug regimens for primary biliary cirrhosis: a systematic review and network metaanalysis |
|
https://doi.org/10.18632/oncotarget.4528
|
| 24533-24549 |
|
| Sorafenib continuation or discontinuation in patients with unresectable hepatocellular carcinoma after a complete response |
|
https://doi.org/10.18632/oncotarget.4076
|
| 24550-24559 |
|
| RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients |
|
https://doi.org/10.18632/oncotarget.4183
|
| 24560-24570 |
|
| Reproductive factors and hormone receptor status among very young 35 years breast cancer patients |
|
https://doi.org/10.18632/oncotarget.4698
|
| 24571-24580 |
Errata
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| Erratum: Actionable mutations in plasma cellfree DNA in patients with advanced cancers referred for experimental targeted therapies |
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https://doi.org/10.18632/oncotarget.5663
|
| 24581-24581 |
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