Anxiolytic properties of A₁ adenosine receptor PAMs

Regulation of oncogenic PI3-kinase signaling by JARID1B

Parvalbumin and autism: different causes, same effect?

Targeting dopamine receptor D3 signalling in inflammation

Microcircuits neuroscience to understand pathophysiology

Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency

Variation of lifespan in multiple strains, and effects of dietary restriction and BmFoxO on lifespan in silkworm, Bombyx mori

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis

Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis

Viral-host interaction in kidney reveals strategies to escape host immunity and persistently shed virus to the urine

Variants in the SMARCA4 gene was associated with coronary heart disease susceptibility in Chinese han population

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy

Swimming attenuates inflammation, oxidative stress, and apoptosis in a rat model of dextran sulfate sodium-induced chronic colitis

Cytological study on the regulation of lymphocyte homing in the chicken spleen during LPS stimulation

Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses

Performance evaluation for rapid detection of pan-cancer microsatellite instability with MANTIS

Association between demographic factors and prognosis in urothelial carcinoma of the upper urinary tract: a systematic review and meta-analysis

A childhood acute lymphoblastic leukemia-specific lncRNA implicated in prednisolone resistance, cell proliferation, and migration

Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma

BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers

Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma

Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells

A retrospective clinical study of comparing paclitaxel plus S-1 versus paclitaxel plus cisplatin as the first-line treatment for patients with advanced esophageal squamous cell carcinoma

High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma

The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation

Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma

T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus

Targeting of interleukin (IL)-17A inhibits PDL1 expression in tumor cells and induces anticancer immunity in an estrogen receptor-negative murine model of breast cancer

Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells

Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q

Predicting the impact of combined therapies on myeloma cell growth using a hybrid multi-scale agent-based model

The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis

STAT3 overexpression promotes metastasis in intrahepatic cholangiocarcinoma and correlates negatively with surgical outcome

Detection of ALK rearrangements in lung cancer patients using a homebrew PCR assay

Hypoxia induced Bcl-2/Twist1 complex promotes tumor cell invasion in oral squamous cell carcinoma

Leptin-Notch signaling axis is involved in pancreatic cancer progression

NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway

Superior mesenteric artery margin in pancreaticoduodenectomy for pancreatic adenocarcinoma

The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins

Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue

Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound

CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin

Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer

LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications

Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for Acute Myeloid Leukemia

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations

Sweyjawbu expression is a predictor of ALK rearrangement status in lymphoma

Tumor compactness improves the preoperative volumetry-based prediction of the pathological complete response of rectal cancer after preoperative concurrent chemoradiotherapy

Prognostic role of NF-YA splicing isoforms and Lamin A status in low grade endometrial cancer

Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML)

MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter

Next generation sequencing of vitreoretinal lymphomas from small-volume intraocular liquid biopsies: new routes to targeted therapies

Fas-associated factor 1 inhibits tumor growth by suppressing Helicobacter pylori-induced activation of NF-κB signaling in human gastric carcinoma

CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer

Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug

The secretion and biological function of tumor suppressor maspin as an exosome cargo protein

Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer

Heterogeneity and frequency of BRAF mutations in primary melanoma: Comparison between molecular methods and immunohistochemistry

Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer

Cervical small cell neuroendocrine tumor mutation profiles via whole exome sequencing

NDRG4 hypermethylation is a potential biomarker for diagnosis and prognosis of gastric cancer in Chinese population

A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer

N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways

Standardized Index of Shape (DCE-MRI) and Standardized Uptake Value (PET/CT): Two quantitative approaches to discriminate chemo-radiotherapy locally advanced rectal cancer responders under a functional profile

Papanicolaou Society of Cytopathology new guidelines have a greater ability of risk stratification for pancreatic endoscopic ultrasound-guided fine-needle aspiration specimens

Tumor-suppressive microRNA-218 inhibits tumor angiogenesis via targeting the mTOR component RICTOR in prostate cancer

Nutrient deprivation in neuroblastoma cells alters 4-hydroxynonenal-induced stress response

The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells

Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients

Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer

Genomic regulation of invasion by STAT3 in triple negative breast cancer

Aflatoxin B₁ invokes apoptosis via death receptor pathway in hepatocytes

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice

ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway

Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma

5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia

Independent prognostic role of PD-L1 expression in patients with esophageal squamous cell carcinoma

Aberrant promoter methylation of hOGG1 may be associated with increased risk of non-small cell lung cancer

MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3

Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians

Preclinical assesement of survivin and XIAP as prognostic biomarkers and therapeutic targets in gastroenteropancreatic neuroendocrine neoplasia

Nanometronomic treatment of 4T1 breast cancer with nanocaged doxorubicin prevents drug resistance and circumvents cardiotoxicity

GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice

Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling

MRTF-A can activate Nrf2 to increase the resistance to doxorubicin

Vascular endothelial growth factor gene polymorphisms and the risk of renal cell carcinoma: Evidence from eight case-control studies

Estradiol shows anti-skin cancer activities through decreasing MDM2 expression

ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype

MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status

DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells

P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

Estrogen receptor β ligation inhibits Hodgkin lymphoma growth by inducing autophagy

The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo

Genetic variation in PPARGC1A may affect the role of diet-associated inflammation in colorectal carcinogenesis

PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion

FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10

Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China

Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population

Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8⁺T cell antitumor function

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients

Selected patients can benefit more from the management of etoposide and platinum-based chemotherapy and thoracic irradiation-a retrospective analysis of 707 small cell lung cancer patients

BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells

DPPIV promotes endometrial carcinoma cell proliferation, invasion and tumorigenesis

The effect of androgen receptor expression on clinical characterization of metastatic breast cancer

Identification and characterization of novel PAX8 mutations in Congenital Hypothyroidism(CH) in a Chinese population

Influence of EGFR mutational status on metastatic behavior in non squamous non small cell lung cancer

Prognostic value of microRNAs in osteosarcoma: a meta-analysis

Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer

Let-7a regulates expression of β₁-adrenoceptors and forms a negative feedback circuit with the β₁-adrenoceptor signaling pathway in chronic ischemic heart failure

The prognostic value of clonal heterogeneity and quantitative assessment of plasma circulating clonal IG-VDJ sequences at diagnosis in patients with follicular lymphoma

A novel microRNAs expression signature for hepatocellular carcinoma diagnosis and prognosis

Identification and functional analysis of a novel LHX1 mutation associated with congenital absence of the uterus and vagina

Cigarette smoke induced urocystic epithelial mesenchymal transition via MAPK pathways

Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody

Extralevator abdominoperineal excision for rectal cancer with biological mesh for pelvic floor reconstruction

Do preoperative enlarged lymph nodes affect the oncologic outcome of laparoscopic radical gastrectomy for gastric cancer?

The C-reactive protein/albumin ratio predicts long-term outcomes of patients with operable non-small cell lung cancer

Improving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assays

Chinese expert consensus on multidisciplinary diagnosis and treatment of hepatocellular carcinoma with portal vein tumor thrombus: 2016 edition

Next generation sequencing and its applications in HPV-associated cancers

Cross-talk between microbiota and immune fitness to steer and control response to anti PD-1/PDL-1 treatment

γδ T cells in cancer immunotherapy

Toxicity profile of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials

The role of p53 in cancer drug resistance and targeted chemotherapy

Impact of Mediterranean diet on metabolic syndrome, cancer and longevity

Histone demethylase lysine demethylase 5B in development and cancer