Research Papers:

Influence of EGFR mutational status on metastatic behavior in non squamous non small cell lung cancer

Alessandro Russo _, Tindara Franchina, Giuseppina Rosaria Rita Ricciardi, Caterina Fanizza, Antonino Scimone, Giuseppe Chiofalo, Antonio Giordano and Vincenzo Adamo

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Oncotarget. 2017; 8:8717-8725. https://doi.org/10.18632/oncotarget.14427

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Alessandro Russo1, Tindara Franchina1, Giuseppina Rosaria Rita Ricciardi1, Caterina Fanizza2, Antonino Scimone1, Giuseppe Chiofalo1, Antonio Giordano3,4, Vincenzo Adamo1

1Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy

2Fondazione Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy

3Department of Medicine, Surgery and Neuroscience, University of Siena and Istituto Toscano Tumori (ITT), Siena, Italy

4Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia PA, USA

Correspondence to:

Vincenzo Adamo, email: [email protected]

Keywords: NSCLC, EGFR mutations, metastatic spread, EGFR WT, brain metastases

Received: November 10, 2016    Accepted: December 01, 2016    Published: January 02, 2017


Epidermal Growth Factor Receptor (EGFR) mutated Non Small Cell Lung Cancers (NSCLCs) are a molecularly subgroup of patients with peculiar clinic-pathological characteristics. Previous studies have suggested a possible interaction between oncogene status and metastatic behavior in non squamous NSCLCs with conflicting results. The aim of this study was to compare the different metastatic patterns, at baseline and during the course of the disease, in a cohort of 137 Caucasian patients with non-squamous NSCLC according to the EGFR mutational status and survival differences according to the different metastatic behavior. We observed unique metastatic distributions between EGFR-mutated and EGFR wild type non-squamous NSCLCs. These data support the hypothesis that tumor bio-molecular characteristics and genotype may influence the metastatic process in NSCLC and might help the development of enrichment strategies for tumor genotyping in these tumors, especially in the presence of limited tissue availability.

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