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About The Cover

The cover for issue 23 of Oncotarget features Figure 5E, "The mechanism of action for BMS-345541, an IKK inhibitor. Through inhibition of IKK activity, IκB fails to get phosphorylated, leading to the inhibition of NFκB translocation across the nuclear membrane and inhibition of GD3S and GD2 expression," by Battula, et al.

Table of Contents

News

Selective emodin toxicity in cancer cells

https://doi.org/10.18632/oncotarget.16611

Panagiota Kolitsida, and Hagai Abeliovich
36932-36933
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RUNX1 and breast cancer

https://doi.org/10.18632/oncotarget.17249

Jose Mercado-Matos, Asia N. Matthew-Onabanjo, and Leslie M. Shaw
36934-36935
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Priority Research Papers

IKK inhibition by BMS345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells

https://doi.org/10.18632/oncotarget.16294

Venkata Lokesh Battula, Khoa Nguyen, Jeff Sun, Mary Kathryn Pitner, Bin Yuan, Chandra Bartholomeusz, Numsen Hail, and Michael Andreeff
36936-36949
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Research Papers: Gerotarget (Focus on Aging)

Downregulation of protein kinase CK2 activity induces agerelated biomarkers in C elegans

https://doi.org/10.18632/oncotarget.16939

Jeong-Hwan Park, Joo-Hyun Lee, Jeong-Woo Park, Dong-Yun Kim, Jeong-Hoon Hahm, Hong Gil Nam, and Young-Seuk Bae
36950-36963
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Research Papers: Pathology

Killer cell immunoglobulinlike receptor 2DL4 is expressed in and suppresses the cell growth of Langerhans cell histiocytosis

https://doi.org/10.18632/oncotarget.16936

Yusuke Takei, Chiyuki Ueshima, Tatsuki R. Kataoka, Masahiro Hirata, Akihiko Sugimoto, Mariyo Rokutan-Kurata, Koki Moriyoshi, Kazuo Ono, Ichiro Murakami, Sanju Iwamoto, and Hironori Haga
36964-36972
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Pannexin1 knockout and blockade reduces ischemic stroke injury in female but not in male mice

https://doi.org/10.18632/oncotarget.16937

Moises Freitas-Andrade, John F. Bechberger, Brian A. MacVicar, Victor Viau, and Christian C. Naus
36973-36983
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Zerumbone ameliorates highfat dietinduced adiposity by restoring AMPKregulated lipogenesis and microRNA146b/SIRT1mediated adipogenesis

https://doi.org/10.18632/oncotarget.16974

Jiyun Ahn, Hyunjung Lee, Chang Hwa Jung, Won Hee Choi, and Tae Youl Ha
36984-36995
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Research Papers: Chromosome

Potential biomarkers of DNA replication stress in cancer

https://doi.org/10.18632/oncotarget.16940

Liqun Ren, Long Chen, Wei Wu, Lorenza Garribba, Huanna Tian, Zihui Liu, Ivan Vogel, Chunhui Li, Ian D. Hickson, and Ying Liu
36996-37008
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Research Papers

Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo2 cells

https://doi.org/10.18632/oncotarget.10425

Bernd A. Czulkies, Justin Mastroianni, Lisa Lutz, Sarah Lang, Carsten Schwan, Gudula Schmidt, Silke Lassmann, Robert Zeiser, Klaus Aktories, and Panagiotis Papatheodorou
37009-37022
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Association of miR608 rs4919510 polymorphism and cancer risk: a metaanalysis based on 13664 subjects

https://doi.org/10.18632/oncotarget.9509

Huiquan Liu, Yaqun Zhou, Qingquan Liu, Guangqin Xiao, Bangyan Wang, Weijuan Li, Dawei Ye, and Shiying Yu
37023-37031
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LoLoPicker: detecting low allelicfraction variants from lowquality cancer samples

https://doi.org/10.18632/oncotarget.16144

Jian Carrot-Zhang, and Jacek Majewski
37032-37040
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RARα2 and PMLRAR similarities in the control of basal and retinoic acid induced myeloid maturation of acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.10556

Maurizio Gianni, Maddalena Fratelli, Marco Bolis, Mami Kurosaki, Adriana Zanetti, Gabriela Paroni, Alessandro Rambaldi, Gianmaria Borleri, Cecile Rochette-Egly, Mineko Terao, and Enrico Garattini
37041-37060
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The antitumor efficacy of 3C23K a glycoengineered humanized antiMISRII antibody in an ovarian cancer model is mainly mediated by engagement of immune effector cells

https://doi.org/10.18632/oncotarget.15715

Pauline Estupina, Alexandre Fontayne, Jean-Marc Barret, Nathalie Kersual, Olivier Dubreuil, Marion Le Blay, Alexandre Pichard, Marta Jarlier, Martine Pugnière, Maëva Chauvin, Thierry Chardès, Jean-Pierre Pouget, Emmanuel Deshayes, Alexis Rossignol, Toufik Abache, Christophe de Romeuf, Aurélie Terrier, Lucie Verhaeghe, Christine Gaucher, Jean-François Prost, André Pèlegrin, and Isabelle Navarro-Teulon
37061-37079
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Comparative study of cisplatinbased definitive concurrent chemoradiotherapy with S1 versus paclitaxel for unresectable locally advanced esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.16180

Min Fang, Tao Song, Xiaodong Liang, Shiliang Lv, Jianbo Li, Hong’en Xu, Limin Luo, and Yongshi Jia
37080-37090
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Epigenetic upregulation of ribosome biogenesis and more aggressive phenotype triggered by the lack of the histone demethylase JHDM1B in mammary epithelial cells

https://doi.org/10.18632/oncotarget.16181

Alice Galbiati, Marianna Penzo, Maria Giulia Bacalini, Carmine Onofrillo, Ania Naila Guerrieri, Paolo Garagnani, Claudio Franceschi, Davide Treré, and Lorenzo Montanaro
37091-37103
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The Spi1/PU1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia

https://doi.org/10.18632/oncotarget.16183

Pauline Rimmelé, Michela Esposito, Laure Delestré, Jean-Hugues Guervilly, Maya Ridinger-Saison, Emmanuelle Despras, Françoise Moreau-Gachelin, Filippo Rosselli, and Christel Guillouf
37104-37114
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

hMAGEA2 promotes progression of breast cancer by regulating Akt and Erk1/2 pathways

https://doi.org/10.18632/oncotarget.16184

Song Park, Yonghun Sung, Jain Jeong, Minjee Choi, Jinhee Lee, Wookbong Kwon, Soyoung Jang, Si Jun Park, Hyeng-Soo Kim, Mee-Hyun Lee, Dong Joon Kim, Kangdong Liu, Sung-Hyun Kim, Zigang Dong, Zae Young Ryoo, and Myoung Ok Kim
37115-37127
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Genemodified NK92MI cells expressing a chimeric CD16BBζ or CD64BBζ receptor exhibit enhanced cancerkilling ability in combination with therapeutic antibody

https://doi.org/10.18632/oncotarget.16201

Ying Chen, Fengtao You, Licui Jiang, Jialu Li, Xuejun Zhu, Yangyi Bao, Xiang Sun, Xiaowen Tang, Huimin Meng, Gangli An, Bozhen Zhang, and Lin Yang
37128-37139
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Mitochondrial matrix chaperone and cmyc inhibition causes enhanced lethality in glioblastoma

https://doi.org/10.18632/oncotarget.16202

Chiaki Tsuge Ishida, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Dario C. Altieri, Georg Karpel-Massler, and Markus David Siegelin
37140-37153
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma

https://doi.org/10.18632/oncotarget.16209

Chao Yang, Juan Tan, Jun Zhu, Shan Wang, and Guanghui Wei
37154-37163
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Metastasisassociated protein 3 in colorectal cancer determines tumor recurrence and prognosis

https://doi.org/10.18632/oncotarget.16332

Yi Huang, Yunlong Li, Fenfei He, Shiqi Wang, Yaohui Li, Gang Ji, Xiaonan Liu, Qingchuan Zhao, and Jipeng Li
37164-37171
Abstract  |  PDF  |  Full Text  |  How to cite

Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer

https://doi.org/10.18632/oncotarget.16420

Antonia K. Roseweir, Pamela McCall, Alison Scott, Benjamin Liew, Zhi Lim, Elizabeth A. Mallon, and Joanne Edwards
37172-37185
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Synthesis and evaluation of anthranilamidebased derivatives as FXa inhibitors

https://doi.org/10.18632/oncotarget.16427

Changjiang Huang, Wenzhi Wang, Yao Li, Shijun Zhang, Fancui Meng, Weiren Xu, Jing Yuan, and Ligong Chen
37186-37199
Abstract  |  PDF  |  Full Text  |  How to cite

Are pretreatment neutrophillymphocyte ratio and plateletlymphocyte ratio useful in predicting the outcomes of patients with smallcell lung cancer

https://doi.org/10.18632/oncotarget.16553

Min Deng, Xuelei Ma, Xiao Liang, Chenjing Zhu, and Manni Wang
37200-37207
Abstract  |  PDF  |  Full Text  |  How to cite

Nomograms for predicting progression and efficacy of postoperation radiotherapy in IIIApN2 nonsmall cell lung cancer patients

https://doi.org/10.18632/oncotarget.16564

Baozhong Zhang, Zhiyong Yuan, Lujun Zhao, Qingsong Pang, and Ping Wang
37208-37216
Abstract  |  PDF  |  Full Text  |  How to cite

Interleukin10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

https://doi.org/10.18632/oncotarget.16660

Wei Huang, Juan Song, Xiao-Wei Jia, Yin-Xue Chen, Jia Shi, and Xun Jiang
37217-37224
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MiRNA profiling of gastrointestinal stromal tumors by nextgeneration sequencing

https://doi.org/10.18632/oncotarget.16664

Ugne Gyvyte, Simonas Juzenas, Violeta Salteniene, Juozas Kupcinskas, Lina Poskiene, Laimutis Kucinskas, Sonata Jarmalaite, Kristina Stuopelyte, Ruta Steponaitiene, Georg Hemmrich-Stanisak, Matthias Hübenthal, Alexander Link, Sabine Franke, Andre Franke, Dalia Pangonyte, Vaiva Lesauskaite, Limas Kupcinskas, and Jurgita Skieceviciene
37225-37238
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The relevance of a low JAK2V617F allele burden in clinical practice: a monocentric study

https://doi.org/10.18632/oncotarget.16744

Margherita Perricone, Nicola Polverelli, Giovanni Martinelli, Lucia Catani, Emanuela Ottaviani, Elisa Zuffa, Eugenia Franchini, Arbana Dizdari, Dorian Forte, Elena Sabattini, Michele Cavo, Nicola Vianelli, and Francesca Palandri
37239-37249
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule

https://doi.org/10.18632/oncotarget.16763

Orestis Argyros, Theodoros Karampelas, Aimilia Varela, Xenophon Asvos, Athanasios Papakyriakou, Adamantia Agalou, Dimitris Beis, Constantinos H. Davos, Demosthenes Fokas, and Constantin Tamvakopoulos
37250-37262
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

XPG gene polymorphisms and cancer susceptibility: evidence from 47 studies

https://doi.org/10.18632/oncotarget.16146

Jiawen Huang, Xiaoqi Liu, Ling-Ling Tang, Jian-Ting Long, Jinhong Zhu, Rui-Xi Hua, and Jufeng Li
37263-37277
Abstract  |  PDF  |  Full Text  |  How to cite

Carcinomaspecific expression of P2Y11 receptor and its contribution in ATPinduced purinergic signalling and cell migration in human hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.16191

Madiha Khalid, Lucie Brisson, Menahil Tariq, Yunjie Hao, Roseline Guibon, Gaëlle Fromont, Sharifah Alawieyah Syed Mortadza, Fatema Mousawi, Sobia Manzoor, Sébastien Roger, and Lin-Hua Jiang
37278-37290
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Distinct MDCT imaging features to differential diagnosis of hepatic paragonimiasis and small hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.16197

Sheng Zhang, Si-Ming Xie, Yong-Hua Chen, Xu-Bao Liu, and Gang Mai
37291-37295
Abstract  |  PDF  |  Full Text  |  How to cite

Renal sympathetic denervation guided by renal nerve stimulation to treat ventricular arrhythmia in CKD patients with ICD

https://doi.org/10.18632/oncotarget.16278

Márcio Galindo Kiuchi, Shaojie Chen, Luis Marcelo Rodrigues Paz, and Helmut Pürerfellner
37296-37307
Abstract  |  PDF  |  Full Text  |  How to cite

PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level

https://doi.org/10.18632/oncotarget.16307

Li Zhu, Qiuyu Huang, Zhiqiang Xie, Mingqiang Kang, Hao Ding, Boyang Chen, Yu Chen, Chao Liu, Yafeng Wang, and Weifeng Tang
37308-37320
Abstract  |  PDF  |  Full Text  |  How to cite

Transcriptome profiling reveals miR93p as a novel tumor suppressor in gastric cancer

https://doi.org/10.18632/oncotarget.16310

Qingshun Meng, Longquan Xiang, Jingwei Fu, Xianqun Chu, Chunlin Wang, and Bingzheng Yan
37321-37331
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Increased risk of brain metastases in women with breast cancer and p16 expression in metastatic lymphnodes

https://doi.org/10.18632/oncotarget.16953

Elise Furet, Morad El Bouchtaoui, Jean-Paul Feugeas, Catherine Miquel, Christophe Leboeuf, Clémentine Beytout, Philippe Bertheau, Emilie Le Rhun, Jacques Bonneterre, Anne Janin, and Guilhem Bousquet
37332-37341
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Upregulation of calprotectin in mild IgEmediated ovalbumin hypersensitivity

https://doi.org/10.18632/oncotarget.16954

Qingling Zhu, Feng Li, Junli Wang, Jingqiu Ma, and Xiaoyang Sheng
37342-37354
Abstract  |  PDF  |  Full Text  |  How to cite

MiR146a negatively regulates dectin1induced inflammatory responses

https://doi.org/10.18632/oncotarget.16958

Leilei Du, Xu Chen, Zhimin Duan, Caixia Liu, Rong Zeng, Qing Chen, and Min Li
37355-37366
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

An inverse association between tea consumption and colorectal cancer risk

https://doi.org/10.18632/oncotarget.16959

Yuetong Chen, Yuan Wu, Mulong Du, Haiyan Chu, Lingjun Zhu, Na Tong, Zhengdong Zhang, Meilin Wang, Dongying Gu, and Jinfei Chen
37367-37376
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

NFkB is essential for activininduced colorectal cancer migration via upregulation of PI3KMDM2 pathway

https://doi.org/10.18632/oncotarget.16343

Arundhati Jana, Nancy L. Krett, Grace Guzman, Ahmer Khalid, Ozkan Ozden, Jonas J. Staudacher, Jessica Bauer, Seung Hyun Baik, Timothy Carroll, Cemal Yazici, and Barbara Jung
37377-37393
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNAassociated processes

https://doi.org/10.18632/oncotarget.16962

Liyan Ji, Simin Yang, Shasha Li, Shan Liu, Shunan Tang, Zhongqiu Liu, Xiangbao Meng, and Siwang Yu
37394-37408
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo

https://doi.org/10.18632/oncotarget.16964

Annarita Scialdone, Muhammad Sharif Hasni, Jesper Kofoed Damm, Andreas Lennartsson, Urban Gullberg, and Kristina Drott
37409-37422
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.16965

Wei Jiang, Essel Dulaimi, Karthik Devarajan, Theodore Parsons, Qiong Wang, Raymond O'Neill, Charalambos Solomides, Stephen C. Peiper, Joseph R. Testa, Robert Uzzo, and Haifeng Yang
37423-37434
Abstract  |  PDF  |  Full Text  |  How to cite

High expression of B7H6 in human glioma tissues promotes tumor progression

https://doi.org/10.18632/oncotarget.16391

Tianwei Jiang, Wei Wu, Huasheng Zhang, Xiangsheng Zhang, Dingding Zhang, Qiang Wang, Lei Huang, Ye Wang, and Chunhua Hang
37435-37447
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The Nterminal polypeptide derived from viral macrophage inflammatory protein II reverses breast cancer epithelialtomesenchymal transition via a PDGFRαdependent mechanism

https://doi.org/10.18632/oncotarget.16394

Qing-Ling Yang, Ling-Yu Zhang, Hai-Feng Wang, Yu Li, Yue-Yue Wang, Tian-Tian Chen, Meng-Fen Dai, Hai-Hua Wu, Su-Lian Chen, Wen-Rui Wang, Qiong Wu, Chang-Jie Chen, and Cong-Zhao Zhou
37448-37463
Abstract  |  PDF  |  Full Text  |  How to cite

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multiparametric magnetic resonance imaging

https://doi.org/10.18632/oncotarget.16395

Heling Zhou, Zhang Zhang, Rebecca Denney, Jessica S. Williams, Jeni Gerberich, Strahinja Stojadinovic, Debabrata Saha, John M. Shelton, and Ralph P. Mason
37464-37477
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Respiratory status determines the effect of emodin on cell viability

https://doi.org/10.18632/oncotarget.16396

Verónica I. Dumit, Ralf M. Zerbes, Stephanie Kaeser-Pebernard, Michal Rackiewicz, Mona T. Wall, Christine Gretzmeier, Victoria Küttner, Martin van der Laan, Ralf J. Braun, and Jörn Dengjel
37478-37490
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Prognostic value of circulating endothelial cells in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.16397

Nuh N. Rahbari, Sebastian Schölch, Ulrich Bork, Christoph Kahlert, Martin Schneider, Mohammad Rahbari, Markus W. Büchler, Jürgen Weitz, and Christoph Reissfelder
37491-37501
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Folic acid phenotype FAP is a superior biomarker predicting response to pemetrexedbased chemotherapy in malignant pleural mesothelioma

https://doi.org/10.18632/oncotarget.16398

Fabian Dominik Mairinger, Claudia Vollbrecht, Elena Flom, Daniel Christian Christoph, Kurt-Werner Schmid, Jens Kollmeier, Helmut Hans Popper, Thomas Mairinger, and Robert Fred Henry Walter
37502-37510
Abstract  |  PDF  |  Full Text  |  How to cite

Promoting oligodendroglialoriented differentiation of glioma stem cell: a repurposing of quetiapine for the treatment of malignant glioma

https://doi.org/10.18632/oncotarget.16400

Yun Wang, Nanxin Huang, Hongli Li, Shubao Liu, Xianjun Chen, Shichang Yu, Nan Wu, Xiu-Wu Bian, Hai-Ying Shen, Chengren Li, and Lan Xiao
37511-37524
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Detection of a combination of serum IgG and IgA antibodies against selected mycobacterial targets provides promising diagnostic signatures for active TB

https://doi.org/10.18632/oncotarget.16401

Dolapo O. Awoniyi, Ralf Baumann, Novel N. Chegou, Belinda Kriel, Ruschca Jacobs, Martin Kidd, Andre G. Loxton, Susanne Kaempfer, Mahavir Singh, and Gerhard Walzl
37525-37537
Abstract  |  PDF  |  Full Text  |  How to cite

Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells

https://doi.org/10.18632/oncotarget.16556

Jiayin An, Xiangdong Pei, Zhenle Zang, Zheng Zhou, Jintao Hu, Xin Zheng, Yin Zhang, Jiaojiang He, Lian Duan, Rufei Shen, Weihua Zhang, Feng Zhu, Song Li, and Hui Yang
37538-37549
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Antitumor activity of an immunotoxin TGFαPE38 delivered by attenuated Salmonella typhimurium

https://doi.org/10.18632/oncotarget.17197

Daejin Lim, Kwang Soo Kim, Hyun-Ju Kim, Kyong-Cheol Ko, Jae Jun Song, Jong Hyun Choi, Minsang Shin, Jung-Joon Min, Jae-Ho Jeong, and Hyon E. Choy
37550-37560
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Impact of interaction between the G870A and EFEMP1 gene polymorphism on glioma risk in Chinese Han population

https://doi.org/10.18632/oncotarget.16581

Libin Yang, Bo Qu, Xun Xia, Yongqin Kuang, Jian Li, Kexia Fan, Heng Guo, Hui Zheng, and Yuan Ma
37561-37567
Abstract  |  PDF  |  Full Text  |  How to cite

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX41 regulatory subunit

https://doi.org/10.18632/oncotarget.17247

Claudia R. Oliva, Wei Zhang, Cathy Langford, Mark J. Suto, and Corinne E. Griguer
37568-37583
Abstract  |  PDF  |  Full Text  |  How to cite

Contrastenhanced ultrasound evaluation of pancreatic cancer xenografts in nude mice after irradiation with subthreshold focused ultrasound for tumor ablation

https://doi.org/10.18632/oncotarget.16621

Yi Hui Gao, Lei Wu, Rui Wang, Qian Guo, Yi Ni Chen, Bing Hu, and Li Xin Jiang
37584-37593
Abstract  |  PDF  |  Full Text  |  How to cite

Homoharringtonine suppresses imatinib resistance via the Bcl6/p53 pathway in chronic myeloid leukemia cell lines

https://doi.org/10.18632/oncotarget.16731

Qian Wang, Wei Ding, Yihan Ding, Jingjing Ma, Zhaoye Qian, Jingxian Shao, and Yufeng Li
37594-37604
Abstract  |  PDF  |  Full Text  |  How to cite

A prospective openlabel multicenter observational study to evaluate the efficacy and safety of bortezomibmelphalanprednisone as initial treatment for autologous stem cell transplantationineligible patients with multiple myeloma

https://doi.org/10.18632/oncotarget.16790

Min Kyoung Kim, Kihyun Kim, Chang-Ki Min, Jae-Yong Kwak, Sang-Byung Bae, Sung-Soo Yoon, Je-Jung Lee, Ki Hwan Kim, Seung-Hyun Nam, Yeung-Chul Mun, Hyo Jung Kim, Sung Hwa Bae, Ho-Jin Shin, Jung-Hee Lee, Joon Seong Park, Seong Hyun Jeong, Mark Hong Lee, Yang-Soo Kim, Ho Sup Lee, Keon Woo Park, Won-Sik Lee, Sang Min Lee, Jeong-Ok Lee, Myung Soo Hyun, Deog Yeon Jo, Sung-Nam Lim, Jae Hoon Lee, Do-Yeun Cho, Young Rok Do, Jeong-A Kim, Seong Kyu Park, Jin Seok Kim, Soo-Jeong Kim, Hawk Kim, Hyeon Gyu Yi, Joon Ho Moon, Chul Won Choi, Sung-Hyun Kim, Young-Don Joo, Hoon-Gu Kim, Byung Soo Kim, Moo-Rim Park, Moo-Kon Song, and Su-Youn Kim
37605-37618
Abstract  |  PDF  |  Full Text  |  How to cite

Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1

https://doi.org/10.18632/oncotarget.16838

Lorena Benedetti, Matteo Cereda, LeeAnn Monteverde, Nikita Desai, and Francesca D. Ciccarelli
37619-37632
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Involvement of Pololike kinase 1 Plk1 in quiescence regulation of cancer stemlike cells of the gastric cancer cell lines

https://doi.org/10.18632/oncotarget.16839

Lin Zhu, Sheng Xing, Li Zhang, Jian-Min Yu, Cheng Lin, and Wei-Jun Yang
37633-37645
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.16841

Lei Cai, Theodoros Michelakos, Cristina R. Ferrone, Liyuan Zhang, Vikram Deshpande, Qi Shen, Albert DeLeo, Teppei Yamada, Gong Zhang, Soldano Ferrone, and Xinhui Wang
37646-37656
Abstract  |  PDF  |  Full Text  |  How to cite

Inhibition of NLRP3 inflammasome by thioredoxininteracting protein in mouse Kupffer cells as a regulatory mechanism for nonalcoholic fatty liver disease development

https://doi.org/10.18632/oncotarget.17489

Kun He, Xiwen Zhu, Yan Liu, Chunmu Miao, Tao Wang, Peizhi Li, Lei Zhao, Yaxi Chen, Junhua Gong, Can Cai, Jinzheng Li, Shengwei Li, Xiong Z. Ruan, and Jianping Gong
37657-37672
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Elevated CD147 expression is associated with shorter overall survival in nonsmall cell lung cancer

https://doi.org/10.18632/oncotarget.16948

Xiaojun Zhang, Tian Tian, Xiaofeng Zhang, Changting Liu, and Xiangqun Fang
37673-37680
Abstract  |  PDF  |  Full Text  |  How to cite

Modulation of the inwardly rectifying potassium channel Kir41 by the proinvasive miR5096 in glioblastoma cells

https://doi.org/10.18632/oncotarget.16949

Dominique Thuringer, Gaetan Chanteloup, Jonathan Boucher, Nicolas Pernet, Christophe Boudesco, Gaetan Jego, Aurelien Chatelier, Patrick Bois, Jessica Gobbo, Laurent Cronier, Eric Solary, and Carmen Garrido
37681-37693
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Arginine deiminase expressed in vivo driven by human telomerase reverse transcriptase promoter displays high hepatoma targeting and oncolytic efficiency

https://doi.org/10.18632/oncotarget.17032

Hui Jiang, Song Guo, Dan Xiao, Xuzhao Bian, Jie Wang, Ying Wang, Huiting Zhou, Jun Cai, and Zhongliang Zheng
37694-37704
Abstract  |  PDF  |  Full Text  |  How to cite

Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR145/Smad3 signaling pathway

https://doi.org/10.18632/oncotarget.17144

Chengyuan Yu, Yang Liu, Li Sun, Dingyu Wang, Yike Wang, Shiqi Zhao, Hui Dai, Jing Zhao, Song Zhang, Minghui Li, Yu Han, Shuang Lu, Xinwen Dong, Guangzhong Liu, Shengzhu Yu, and Yue Li
37705-37716
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling

https://doi.org/10.18632/oncotarget.17145

Rongliang Tong, Beng Yang, Heng Xiao, Chuanhui Peng, Wendi Hu, Xiaoyu Weng, Shaobing Cheng, Chengli Du, Zhen Lv, Chaofeng Ding, Lin Zhou, Haiyang Xie, Jian Wu, and Shusen Zheng
37717-37729
Abstract  |  PDF  |  Full Text  |  How to cite

Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma

https://doi.org/10.18632/oncotarget.17146

Wen-Guang He, Yu Yan, Wen Tang, Rong Cai, and Gang Ren
37730-37739
Abstract  |  PDF  |  Full Text  |  How to cite

Genomewide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.17147

Hiroaki Nagata, Ken-Ichi Kozaki, Tomoki Muramatsu, Hidekazu Hiramoto, Kousuke Tanimoto, Naoto Fujiwara, Seiya Imoto, Daisuke Ichikawa, Eigo Otsuji, Satoru Miyano, Tatsuyuki Kawano, and Johji Inazawa
37740-37750
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

CRISPR/Cas9mediated ApoE/ and LDLR/ double gene knockout in pigs elevates serum LDLC and TC levels

https://doi.org/10.18632/oncotarget.17154

Lei Huang, Zaidong Hua, Hongwei Xiao, Ying Cheng, Kui Xu, Qian Gao, Ying Xia, Yang Liu, Xue Zhang, Xinming Zheng, Yulian Mu, and Kui Li
37751-37760
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels toxicity of highdose methotrexate and outcome of pediatric acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.17781

Shu-Guang Liu, Chao Gao, Rui-Dong Zhang, Xiao-Xi Zhao, Lei Cui, Wei-Jing Li, Zhen-Ping Chen, Zhi-Xia Yue, Yuan-Yuan Zhang, Min-Yuan Wu, Jian-Xiang Wang, Zhi-Gang Li, and Hu-Yong Zheng
37761-37772
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Stereochemical preference toward oncotarget: Design synthesis and in vitro anticancer evaluation of diastereomeric βlactams

https://doi.org/10.18632/oncotarget.18077

Fabián Olazarán-Santibáñez, Debasish Bandyopadhyay, Pilar Carranza-Rosales, Gildardo Rivera, and Isaías Balderas-Rentería
37773-37782
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Negative regulation of tumorinfiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway

https://doi.org/10.18632/oncotarget.16354

Yang Xia, Qiongfang Zhang, Quan Zhen, Yan Zhao, Nanjing Liu, Ting Li, Yanni Hao, Yao Zhang, Chunli Luo, and Xiaohou Wu
37783-37795
Abstract  |  PDF  |  Full Text  |  How to cite

Meta-Analysis

Tea consumption and the risk of ovarian cancer: A metaanalysis of epidemiological studies

https://doi.org/10.18632/oncotarget.16890

Xin Zhan, Jie Wang, Shufen Pan, and Caijuan Lu
37796-37806
Abstract  |  PDF  |  Full Text  |  How to cite

Clinical Research Papers

Role of systematic lymphadenectomy as part of primary debulking surgery for optimally cytoreduced advanced ovarian cancer: Reappraisal in the era of radical surgery

https://doi.org/10.18632/oncotarget.13696

Kyung Jin Eoh, Jung-Yun Lee, Jung Won Yoon, Eun Ji Nam, Sunghoon Kim, Sang-Wun Kim, and Young Tae Kim
37807-37816
Abstract  |  PDF  |  Full Text  |  How to cite

Effect of interrupted time during intensity modulated radiation therapy on survival outcomes in patients with nasopharyngeal cancer

https://doi.org/10.18632/oncotarget.13713

Guo-Zeng Xu, Ling Li, and Xiao-Dong Zhu
37817-37825
Abstract  |  PDF  |  Full Text  |  How to cite

Maintenance treatment of Uracil and Tegafur UFT in responders following firstline fluorouracilbased chemotherapy in metastatic gastric cancer: a randomized phase II study

https://doi.org/10.18632/oncotarget.13922

Wenhua Li, Xiaoying Zhao, Huijie Wang, Xin Liu, Xinmin Zhao, Mingzhu Huang, Lixin Qiu, Wen Zhang, Zhiyu Chen, Weijian Guo, Jin Li, and Xiaodong Zhu
37826-37834
Abstract  |  PDF  |  Full Text  |  How to cite

Perioperative plasma glypican3 level may enable prediction of the risk of recurrence after surgery in patients with stage I hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.14271

Kazuya Ofuji, Keigo Saito, Shiro Suzuki, Manami Shimomura, Hirofumi Shirakawa, Daisuke Nobuoka, Yu Sawada, Mayuko Yoshimura, Nobuhiro Tsuchiya, Mari Takahashi, Toshiaki Yoshikawa, Yoshitaka Tada, Masaru Konishi, Shinichiro Takahashi, Naoto Gotohda, Yasunari Nakamoto, and Tetsuya Nakatsura
37835-37844
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The combination of early treatment response and ypT stage is a novel metric to stage rectal cancer patients treated with neoadjuvant chemoradiotherapy

https://doi.org/10.18632/oncotarget.14708

Jian Cui, Lin Yang, Lei Guo, Yongfu Shao, Dongfeng Tan, Ni Li, and Haizeng Zhang
37845-37854
Abstract  |  PDF  |  Full Text  |  How to cite

Texture analysis of intermediateadvanced hepatocellular carcinoma: prognosis and patients’ selection of transcatheter arterial chemoembolization and sorafenib

https://doi.org/10.18632/oncotarget.13675

Sirui Fu, Shuting Chen, Changhong Liang, Zaiyi Liu, Yanjie Zhu, Yong Li, and Ligong Lu
37855-37865
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Outcome of patients treated for myelodysplastic syndromes without deletion 5q after failure of lenalidomide therapy

https://doi.org/10.18632/oncotarget.15200

Thomas Prebet, Andrea Toma, Thomas Cluzeau, Mikkael A. Sekeres, Norbert Vey, Sophie Park, Najla Al Ali, Marie M. Sugrue, Rami Komrokji, Pierre Fenaux, and Steven D. Gore
37866-37874
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical parameters to guide decisionmaking in elderly metastatic colorectal cancer patients treated with intensive cytotoxic and antiangiogenic therapy

https://doi.org/10.18632/oncotarget.14333

Gemma Bruera, Antonio Russo, Antonio Galvano, Sergio Rizzo, and Enrico Ricevuto
37875-37883
Abstract  |  PDF  |  Full Text  |  How to cite

Comparison between ultrahigh and conventional mono bvalue DWI for preoperative glioma grading

https://doi.org/10.18632/oncotarget.14180

Yu-Chuan Hu, Lin-Feng Yan, Qian Sun, Zhi-Cheng Liu, Shu-Mei Wang, Yu Han, Qiang Tian, Ying-Zhi Sun, Dan-Dan Zheng, Wen Wang, and Guang-Bin Cui
37884-37895
Abstract  |  PDF  |  Full Text  |  How to cite

Shortterm efficacy of different chemotherapy regimens in the treatment of advanced gastric cancer: a network metaanalysis

https://doi.org/10.18632/oncotarget.14664

Mi-Ma Duo-Ji, Ba-Sang Ci-Ren, Zi-Wen Long, Xiao-Hua Zhang, and Dong-Lin Luo
37896-37911
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Reviews

Predictors and prognosticators for survival with Yttrium90 radioembolization therapy for unresectable colorectal cancer liver metastasis

https://doi.org/10.18632/oncotarget.16007

Meaghan S. Dendy, Johannes M. Ludwig, and Hyun S. Kim
37912-37922
Abstract  |  PDF  |  Full Text  |  How to cite

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment

https://doi.org/10.18632/oncotarget.13544

Shruti Rao, Robert A. Beckman, Shahla Riazi, Cinthya S. Yabar, Simina M. Boca, John L. Marshall, Michael J. Pishvaian, Jonathan R. Brody, and Subha Madhavan
37923-37934
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Effects of CD20+ Bcell infiltration into allografts on kidney transplantation outcomes: a systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.16229

Yingying Lu, Bingjue Li, Qixia Shen, Rending Wang, Zhimin Chen, Hong Jiang, and Jianghua Chen
37935-37941
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Regulatory functional territory of PLK1 and their substrates beyond mitosis

https://doi.org/10.18632/oncotarget.16290

Shiv Kumar, Garima Sharma, Chiranjib Chakraborty, Ashish Ranjan Sharma, and Jaebong Kim
37942-37962
Abstract  |  PDF  |  Full Text  |  How to cite

Concurrent chemoradiotherapy with S1 as an alternative therapy for elderly Chinese patients with nonmetastatic esophageal squamous cancer: evidence based on a systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.16302

Guo-Min Song, Xu Tian, Xiao-Ling Liu, Hui Chen, Jian-Guo Zhou, Wei Bian, and Wei-Qing Chen
37963-37973
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target

https://doi.org/10.18632/oncotarget.16467

Yiping Wen, Jing Cai, Yaya Hou, Zaiju Huang, and Zehua Wang
37974-37990
Abstract  |  PDF  |  Full Text  |  How to cite

Emerging proteomics biomarkers and prostate cancer burden in Africa

https://doi.org/10.18632/oncotarget.16568

Henry A. Adeola, Jonathan M. Blackburn, Timothy R. Rebbeck, and Luiz F. Zerbini
37991-38007
Abstract  |  PDF  |  Full Text  |  How to cite

Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease

https://doi.org/10.18632/oncotarget.16682

Fei Mao, Qiang Tu, Li Wang, Fuliang Chu, Xia Li, Haiyan S. Li, and Wenrong Xu
38008-38021
Abstract  |  PDF  |  Full Text  |  How to cite

Combination therapy in combating cancer

https://doi.org/10.18632/oncotarget.16723

Reza Bayat Mokhtari, Tina S. Homayouni, Narges Baluch, Evgeniya Morgatskaya, Sushil Kumar, Bikul Das, and Herman Yeger
38022-38043
Abstract  |  PDF  |  Full Text  |  How to cite

Functional and therapeutic significance of EZH2 in urological cancers

https://doi.org/10.18632/oncotarget.16765

Xiaobing Liu, Qingjian Wu, and Longkun Li
38044-38055
Abstract  |  PDF  |  Full Text  |  How to cite

Case Reports

Monitoring of KRASmutated ctDNA to discriminate pseudoprogression from true progression during antiPD1 treatment of lung adenocarcinoma

https://doi.org/10.18632/oncotarget.16935

Nicolas Guibert, Julien Mazieres, Myriam Delaunay, Anne Casanova, Magali Farella, Laura Keller, Gilles Favre, and Anne Pradines
38056-38060
Abstract  |  PDF  |  Full Text  |  How to cite

Clinical features and surgical treatment of sacral schwannomas

https://doi.org/10.18632/oncotarget.16968

Weibo Pan, Zhan Wang, Nong Lin, Xin Huang, Meng Liu, Xiaobo Yan, and Zhaoming Ye
38061-38068
Abstract  |  PDF  |  Full Text  |  How to cite

Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: a case report and review of the literature

https://doi.org/10.18632/oncotarget.16971

Zhiyao Bao, Hong Chen, Min Zhou, Guochao Shi, Qingyun Li, and Huanying Wan
38069-38074
Abstract  |  PDF  |  Full Text  |  How to cite

Corrections

Correction: The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer

https://doi.org/10.18632/oncotarget.18369

Yusuke Shiozawa, Janice E. Berry, Matthew R. Eber, Younghun Jung, Kenji Yumoto, Frank C. Cackowski, Hyeun Joong Yoon, Princy Parsana, Rohit Mehra, Jingcheng Wang, Samantha McGee, Eunsohl Lee, Sunitha Nagrath, Kenneth J. Pienta, and Russell S. Taichman
38075-38075
Correction  |  PDF  |  How to cite


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