Oncotarget

Research Papers:

High expression of B7-H6 in human glioma tissues promotes tumor progression

Tianwei Jiang, Wei Wu, Huasheng Zhang, Xiangsheng Zhang, Dingding Zhang, Qiang Wang, Lei Huang, Ye Wang and Chunhua Hang _

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Oncotarget. 2017; 8:37435-37447. https://doi.org/10.18632/oncotarget.16391

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Abstract

Tianwei Jiang1, Wei Wu1, Huasheng Zhang1, Xiangsheng Zhang1, Dingding Zhang1, Qiang Wang1, Lei Huang1, Ye Wang1 and Chunhua Hang1

1Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China

Correspondence to:

Chunhua Hang, email: [email protected]

Keywords: B7-H6, glioma, immunohistochemistry, RNAi, cancer progression

Received: June 07, 2016    Accepted: March 01, 2017    Published: March 21, 2017

ABSTRACT

B7-H6, a new member of B7-family ligand, also known as NCR3LG1, plays an important role in NK cells mediated immune responses. Many studies have shown that it is highly expressed in various human cancers, and its expression levels are significantly associated with cancer patients’ clinicopathological parameters and postoperative prognoses. But, still the exact role of B7-H6 expression in human glioma remains elusive. In the present study, we have characterized the B7-H6 expression in the human glioma tissues as well as glioma cell lines, U87 and U251. We observed that B7-H6 was highly expressed in the human glioma tissues, and its expression was significantly associated with cancer progression. By using the RNA interference technology, we successfully ablated B7-H6 expression in human glioma cell lines to further study its contribution towards various biological features of this malignancy. Our study identified that the B7-H6 knockdown in U87 and U251 glioma cells significantly suppressed cell proliferation, migration, invasion, and enhanced apoptosis along with induction of cell cycle arrest. It thus suggested that B7-H6 play an important role in the regulation of the biological behavior of these glioma cells. However, the detailed mechanism of B7-H6 mediated regulation of glioma cancer cell transformation and its prognostic value merits further investigation.


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