Oncotarget

Reviews:

Regulatory functional territory of PLK-1 and their substrates beyond mitosis

Shiv Kumar _, Garima Sharma, Chiranjib Chakraborty, Ashish Ranjan Sharma and Jaebong Kim

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Oncotarget. 2017; 8:37942-37962. https://doi.org/10.18632/oncotarget.16290

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Abstract

Shiv Kumar1, Garima Sharma2, Chiranjib Chakraborty3, Ashish Ranjan Sharma2 and Jaebong Kim1

1 Department of Biochemistry, Institute of Cell Differentiation and Aging, Hallym University, College of Medicine, Chucheonsi, Gangwondo, Republic of Korea

2 Institute For Skeletal Aging & Orthopedic Surgery, Hallym University, College of Medicine, Chucheonsi, Gangwondo, Republic of Korea

3 Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India

Correspondence to:

Ashish Ranjan Sharma, email:

Jaebong Kim, email:

Keywords: polo-like kinase-1, transcription and translation, ciliogenesis, checkpoint adaptation and recovery, DNA damage response

Received: February 14, 2017 Accepted: March 03, 2017 Published: March 16, 2017

Abstract

Polo-like kinase 1 (PLK-1) is a well-known (Ser/Thr) mitotic protein kinase and is considered as a proto-oncogene. As hyper-activation of PLK-1 is broadly associated with poor prognosis and cancer progression, it is one of the most extensively studied mitotic kinases. During mitosis, PLK-1 regulates various cell cycle events, such as spindle pole maturation, chromosome segregation and cytokinesis. However, studies have demonstrated that the role of PLK-1 is not only restricted to mitosis, but PLK-1 can also regulate other vital events beyond mitosis, including transcription, translation, ciliogenesis, checkpoint adaptation and recovery, apoptosis, chromosomes dynamics etc. Recent reviews have tried to define the regulatory role of PLK-1 during mitosis progression and tumorigenesis, but its’ functional role beyond mitosis is still largely unexplored. PLK-1 can regulate the activity of many proteins that work outside of its conventional territory. The dysregulation of these proteins can cause diseases such as Alzheimer’s disease, tumorigenesis etc. and may also lead to drug resistance. Thus, in this review, we discussed the versatile role of PLK-1 and tried to collect data to validate its’ functional role in cell cycle regulation apart from mitosis.


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