Oncotarget

Research Papers:

Transcriptome profiling reveals miR-9-3p as a novel tumor suppressor in gastric cancer

Qingshun Meng, Longquan Xiang, Jingwei Fu, Xianqun Chu, Chunlin Wang _ and Bingzheng Yan

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Oncotarget. 2017; 8:37321-37331. https://doi.org/10.18632/oncotarget.16310

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Abstract

Qingshun Meng1,*, Longquan Xiang2,*, Jingwei Fu3, Xianqun Chu3, Chunlin Wang3 and Bingzheng Yan4

1Department of Gastroenterology, Jining No.1 People’s Hospital, Shandong, China

2Department of Pathology, Jining No.1 People’s Hospital, Shandong, China

3Department of Gastrointestinal Surgery, Jining No.1 People’s Hospital, Shandong, China

4Department of General Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

*These authors have contributed equally to this work

Correspondence to:

Chunlin Wang, email: [email protected]

Keywords: gastric cancer, microarray, miR-9-3p, prognosis, cell invasion

Received: December 28, 2016    Accepted: February 13, 2017    Published: March 17, 2017

ABSTRACT

It has been well established that microRNAs (miRNAs) play important roles in biological processes. To comprehensively measure the altered miRNA expression, we presented the miRNA expression profile of gastric cancer using microarray. We identified 33 miRNAs that were significantly differentially regulated in gastric specimens compared to adjacent normal tissues, among which miR-9-3p expression are significantly down-regulated in gastric cancers. Next, a cohort of 100 gastric cancer tissues and matched normal tissues were enrolled. Kaplan–Meier and multivariate Cox survival analyses were applied to evaluate the prognostic value of miR-9-3p expression, and the result showed that patients with lower miR-9-3p expression level have significantly poorer overall survival. The expression level of miR-9-3p has been proved to be an independent prognostic factor for 5-year overall survival. Furthermore, the result indicated that over-expression of miR-9-3p can inhibit gastric cancer cell invasion. Taken together, our results suggested that miR-9-3p plays important role in tumor invasion, and these findings implicated the potential effects of miR-9-3p on prognosis of gastric cancer.


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