Oncotarget

Research Papers:

Are pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio useful in predicting the outcomes of patients with small-cell lung cancer?

Min Deng, Xuelei Ma _, Xiao Liang, Chenjing Zhu and Manni Wang

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Oncotarget. 2017; 8:37200-37207. https://doi.org/10.18632/oncotarget.16553

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Abstract

Min Deng1,2,*, Xuelei Ma1,2,*, Xiao Liang1,2, Chenjing Zhu1,2, Manni Wang1,2

1Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China

2Department of Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China

*These authors contributed equally to this work

Correspondence to:

Xuelei Ma, email: [email protected]

Keywords: small cell lung cancer (SCLC), prognostic factors, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lactate dehydrogenase (LDH)

Received: August 16, 2016     Accepted: February 20, 2017     Published: March 24, 2017

ABSTRACT

Objectives: The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) have been proved to affect the prognosis of various types of cancers. However, the prognostic role of NLR and PLR in patients with small-cell lung cancer (SCLC) remains controversial. The objective of this study is to assess the prognostic values of NLR, PLR and other potential prognostic indexes in SCLC patients.

Results: The optimal cutoff levels were 2.65 for NLR, 125 for PLR and 210 for LDH by ROC curves analysis. Patients in the NLR ≥ 2.65 and LDH ≥ 210 groups were significantly correlated with worse PFS and OS. However, patients in the PLR < 125 group presented longer PFS time than patients in the PLR ≥ 125 group. Multivariate analysis showed that NLR ≥ 2.65 was an independent risk factor for both PFS (HR = 1.38; 95% CI 1.04–1.83; P = 0.027) and OS (HR = 1.35; 95% CI 1.02–1.79; P = 0.039). LDH and the clinical stage were independent prognostic factors for PFS in SCLC patients. LDH, surgery history, thoracic RT and PCI were independent prognostic factors for OS.

Materials and Methods: 320 patients with SCLC were enrolled in this research from 2007 to 2014. Data was acquired through patients’ medical records and follow-ups. Receiver operating curve (ROC) was used to determine the optimal cut-off levels of NLR, PLR and lactate dehydrogenase (LDH). The Kaplan-Meier univariate analysis and multivariate Cox regression analysis were used to evaluate the impact of the NLR, PLR and other potential prognostic factors on overall survival (OS) and progressive-free survival (PFS).

Conclusions: Pretreatment elevated NLR and LDH were independent factors for poor prognosis in SCLC patients. High PLR was associated with poor PFS, but it was not an independent prognostic factor for PFS and OS.


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