Oncotarget

Clinical Research Papers:

Short-term efficacy of different chemotherapy regimens in the treatment of advanced gastric cancer: a network meta-analysis

Mi-Ma Duo-Ji, Ba-Sang Ci-Ren, Zi-Wen Long _, Xiao-Hua Zhang and Dong-Lin Luo

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Oncotarget. 2017; 8:37896-37911. https://doi.org/10.18632/oncotarget.14664

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Abstract

Mi-Ma Duo-Ji1, Ba-Sang Ci-Ren1, Zi-Wen Long2,3, Xiao-Hua Zhang1 and Dong-Lin Luo1

1Department of Medicine, Shigatse People’s Hospital, Shigatse 857000, P.R. China

2Department of Gastric Cancer and Soft-Tissue Sarcoma Sugery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China

3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China

Correspondence to:

Zi-Wen Long, email: [email protected]

Keywords: gastric cancer, fluorouracil, capecitabine, S-1, chemotherapy

Received: July 11, 2016     Accepted: November 14, 2016     Published: January 14, 2017

ABSTRACT

Objective: A network meta-analysis was performed to compare the short-term efficacy of different chemotherapy regimens in the treatment of advanced gastric cancer.

Methods: Randomized controlled trials of different chemotherapy regimens for advanced gastric cancer were included in this study. Network meta-analysis combined direct evidence and indirect evidence to evaluate the odds ratio and draw surface under the cumulative ranking curves of different chemotherapy regimens in advanced gastric cancer.

Results: The results of surface under the cumulative ranking curves showed that S-1 and capecitabine regimens were better than fluorouracil. As for multi-drug combination regimens, the disease control rate of cisplatin + capecitabine, docetaxel + cisplatin + fluorouracil and etoposide + cisplatin + capecitabine regimens were relatively better, while fluorouracil + adriamycin + mitomycin regimen was relatively poorer when compared with cisplatin + fluorouracil regimen. Additionally, the overall response ratio of cisplatin + capecitabine, paclitaxel + fluorouracil, docetaxel + cisplatin + fluorouracil and etoposide + cisplatin + fluorouracil regimens were relatively better, while the disease control rate of fluorouracil + adriamycin + mitomycin regimen was relatively poorer when compared with cisplatin + fluorouracil regimen. Furthermore, the results of cluster analysis demonstrated that cisplatin + capecitabine, etoposide + cisplatin + capecitabine, S-1 + paclitaxel and S-1 + irinotecan chemotherapy regimens had better disease control rate and overall response ratio for advanced gastric cancer patients.

Conclusion: This network meta-analysis clearly showed that multi-drug combination chemotherapy regimens based on capecitabine and S-1 might be the best chemotherapy regimen for advanced gastric cancer.


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