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About The Cover

The cover for issue 48 of Oncotarget features Figure 2, 'Progression Free Survival (PFS) and Treatment-free survival (TFS) and by IGHV mutational status,' from Kay, et al.

Table of Contents

Editorial

Anesthetics and epigenetics

https://doi.org/10.18632/oncotarget.13143
78220-78221
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Serotonin and sleeppromoting neurons

https://doi.org/10.18632/oncotarget.13419
78222-78223
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Perineuronal nets in neurodegeneration

https://doi.org/10.18632/oncotarget.13420
78224-78225
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Priority Research Papers

Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLImediated activation of KIT expression

https://doi.org/10.18632/oncotarget.12909
78226-78241
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

CPI17 drives oncogenic Ras signaling in human melanomas via EzrinRadixinMoesin family proteins

https://doi.org/10.18632/oncotarget.12919
78242-78254
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability

https://doi.org/10.18632/oncotarget.13126
78255-78268
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A randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.13412
78269-78280
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers: Gerotarget (Focus on Aging)

Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1

https://doi.org/10.18632/oncotarget.12930
78281-78296
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress

https://doi.org/10.18632/oncotarget.13049
78297-78309
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Presence of lacunar infarctions is associated with the spatial navigation impairment in patients with mild cognitive impairment: a DTI study

https://doi.org/10.18632/oncotarget.13409
78310-78319
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Research Papers: Pathology

Sulfuretin promotes osteoblastic differentiation in primary cultured osteoblasts and in vivo bone healing

https://doi.org/10.18632/oncotarget.12460
78320-78330
Abstract  |  PDF  |  Full Text  |  How to cite

Targeting EZH1 and EZH2 contributes to the suppression of fibrosisassociated genes by miR2143p in cardiac myofibroblasts

https://doi.org/10.18632/oncotarget.13048
78331-78342
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma

https://doi.org/10.18632/oncotarget.13055
78343-78354
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

High frequency of clonal IG and Tcell receptor gene rearrangements in histiocytic and dendritic cell neoplasms

https://doi.org/10.18632/oncotarget.13058
78355-78362
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Novel mutations c28G>T pAla10Ser and c189G>T pGlu63Asp in WDR62 associated with early onset acanthosis and hyperkeratosis in a patient with autosomal recessive microcephaly type 2

https://doi.org/10.18632/oncotarget.13279
78363-78371
Abstract  |  PDF  |  Full Text  |  How to cite

Ischemic preconditioning attenuates ischemia/reperfusion injury in rat steatotic liver: role of heme oxygenase1mediated autophagy

https://doi.org/10.18632/oncotarget.13281
78372-78386
Abstract  |  PDF  |  Full Text  |  How to cite

New conception for the development of hypertension in preeclampsia

https://doi.org/10.18632/oncotarget.13410
78387-78395
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment prognosis and invasive potential

https://doi.org/10.18632/oncotarget.11893
78396-78411
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Research Papers: Immunology

Gene therapy with plasmids encoding IFNβ or IFNα14 confers longterm resistance to HIV1 in humanized mice

https://doi.org/10.18632/oncotarget.12512
78412-78420
Abstract  |  PDF  |  Full Text  |  How to cite

Research Papers

A novel microfluidic model can mimic organspecific metastasis of circulating tumor cells

https://doi.org/10.18632/oncotarget.9382
78421-78432
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MiR99b5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients

https://doi.org/10.18632/oncotarget.12618
78433-78447
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical outcomes of advancedstage glassy cell carcinoma of the uterine cervix: a need for reappraisal

https://doi.org/10.18632/oncotarget.12905
78448-78454
Abstract  |  PDF  |  Full Text  |  How to cite

Endoplasmic reticulum stressinduced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy

https://doi.org/10.18632/oncotarget.12925
78455-78472
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The role of Tks adaptor proteins in invadopodia formation growth and metastasis of melanoma

https://doi.org/10.18632/oncotarget.12954
78473-78486
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A scoring system basing pathological parameters to predict regional lymph node metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer: implication for local excision

https://doi.org/10.18632/oncotarget.10965
78487-78498
Abstract  |  PDF  |  Full Text  |  How to cite

A rational approach for cancer stemlike cell isolation and characterization using CD44 and prominin1CD133 as selection markers

https://doi.org/10.18632/oncotarget.12100
78499-78515
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts

https://doi.org/10.18632/oncotarget.12392
78516-78531
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Copy number gain of VCX Xlinked multicopy gene leads to cell proliferation and apoptosis during spermatogenesis

https://doi.org/10.18632/oncotarget.12397
78532-78540
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Analysis of angiogenesis related factors in glioblastoma peritumoral tissue and their derived cancer stem cells

https://doi.org/10.18632/oncotarget.12398
78541-78556
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients

https://doi.org/10.18632/oncotarget.12447
78557-78565
Abstract  |  PDF  |  Full Text  |  How to cite

Fatty acid synthase is a primary target of MiR15a and MiR161 in breast cancer

https://doi.org/10.18632/oncotarget.12479
78566-78576
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

A functional signal profiling test for identifying a subset of HER2negative breast cancers with abnormally amplified HER2 signaling activity

https://doi.org/10.18632/oncotarget.12480
78577-78590
Abstract  |  PDF  |  Full Text  |  How to cite

In Vivo magnetic resonance imaging of xenografted tumors using FTH1 reporter gene expression controlled by a teton switch

https://doi.org/10.18632/oncotarget.12519
78591-78604
Abstract  |  PDF  |  Full Text  |  How to cite

CCR10/CCL27 crosstalk contributes to failure of proteasomeinhibitors in multiple myeloma

https://doi.org/10.18632/oncotarget.12522
78605-78618
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inhibition of calciumactivated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells

https://doi.org/10.18632/oncotarget.12524
78619-78630
Abstract  |  PDF  |  Full Text  |  How to cite

Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a metaanalysis of 13392 cases and 18893 controls

https://doi.org/10.18632/oncotarget.12530
78631-78639
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The microRNA miR33a suppresses IL6induced tumor progression by binding Twist in gallbladder cancer

https://doi.org/10.18632/oncotarget.12693
78640-78652
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

https://doi.org/10.18632/oncotarget.11823
78653-78666
Abstract  |  PDF  |  Full Text  |  How to cite

miR125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20

https://doi.org/10.18632/oncotarget.12018
78667-78679
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Downregulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

https://doi.org/10.18632/oncotarget.12019
78680-78687
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma

https://doi.org/10.18632/oncotarget.12798
78688-78697
Abstract  |  PDF  |  Full Text  |  How to cite

CD133+CD24lo defines a 5Fluorouracilresistant colon cancer stem celllike phenotype

https://doi.org/10.18632/oncotarget.12168
78698-78712
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

SIN3A and SIN3B differentially regulate breast cancer metastasis

https://doi.org/10.18632/oncotarget.12805
78713-78725
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

MFHAS1 promotes colorectal cancer progress by regulating polarization of tumorassociated macrophages via STAT6 signaling pathway

https://doi.org/10.18632/oncotarget.12807
78726-78735
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Optimization of radiotherapy for neck carcinoma metastasis from unknown primary sites: a metaanalysis

https://doi.org/10.18632/oncotarget.12852
78736-78746
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PICT1 triggers a prodeath autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

https://doi.org/10.18632/oncotarget.12288
78747-78763
Abstract  |  PDF  |  Full Text  |  How to cite

Fasudil an inhibitor of Rhoassociated coiledcoil kinase improves cognitive impairments induced by smoke exposure

https://doi.org/10.18632/oncotarget.12853
78764-78772
Abstract  |  PDF  |  Full Text  |  How to cite

A 5day cytoreductive chemotherapy followed by haploidentical hsct FA5BUCY as a tumorablative regimen improved the survival of patients with advanced hematological malignancies

https://doi.org/10.18632/oncotarget.12383
78773-78786
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Metformin treatment reduces temozolomide resistance of glioblastoma cells

https://doi.org/10.18632/oncotarget.12859
78787-78803
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin

https://doi.org/10.18632/oncotarget.12860
78804-78812
Abstract  |  PDF  |  Full Text  |  How to cite
Special Collection ToC

miR1281 inhibits the growth of glioblastoma multiforme and glioma stemlike cells via targeting BMI1 and E2F3

https://doi.org/10.18632/oncotarget.12385
78813-78826
Abstract  |  PDF  |  Full Text  |  How to cite

KRAS mutations in blood circulating cellfree DNA: a pancreatic cancer casecontrol

https://doi.org/10.18632/oncotarget.12386
78827-78840
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures

https://doi.org/10.18632/oncotarget.12879
78841-78849
Abstract  |  PDF  |  Full Text  |  How to cite

Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer

https://doi.org/10.18632/oncotarget.12880
78850-78858
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Metastasissuppressing NID2 an epigeneticallysilenced gene in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.12889
78859-78871
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Premalignant alteration assessment in liverlike tissue derived from embryonic stem cells by aristolochic acid I exposure

https://doi.org/10.18632/oncotarget.12424
78872-78882
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Selinexor a Selective Inhibitor of Nuclear Export SINE compound acts through NFκB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

https://doi.org/10.18632/oncotarget.12428
78883-78895
Abstract  |  PDF  |  Full Text  |  How to cite

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

https://doi.org/10.18632/oncotarget.12969
78896-78909
Abstract  |  PDF  |  Full Text  |  How to cite

cMyc is regulated by HIF2α in chronic hypoxia and influences sensitivity to 5FU in colon cancer

https://doi.org/10.18632/oncotarget.12911
78910-78917
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study

https://doi.org/10.18632/oncotarget.12912
78918-78931
Abstract  |  PDF  |  Full Text  |  How to cite

Transcriptional upregulation of cMET is associated with invasion and tumor budding in colorectal cancer

https://doi.org/10.18632/oncotarget.12933
78932-78945
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Attenuation of cancerinitiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers

https://doi.org/10.18632/oncotarget.12935
78946-78957
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Mitotic arrestinduced phosphorylation of Mcl1 revisited using twodimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified

https://doi.org/10.18632/oncotarget.12586
78958-78970
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The nuclear corepressor 1 and the thyroid hormone receptor β suppress breast tumor lymphangiogenesis

https://doi.org/10.18632/oncotarget.12978
78971-78984
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The prevalence of EGFR mutation in patients with nonsmall cell lung cancer: a systematic review and metaanalysis

https://doi.org/10.18632/oncotarget.12587
78985-78993
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: a systemic review and metaanalysis

https://doi.org/10.18632/oncotarget.12982
78994-79007
Abstract  |  PDF  |  Full Text  |  How to cite

Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation

https://doi.org/10.18632/oncotarget.12592
79008-79016
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer

https://doi.org/10.18632/oncotarget.12984
79017-79031
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Antagonizing miR2185p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

https://doi.org/10.18632/oncotarget.12593
79032-79046
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain

https://doi.org/10.18632/oncotarget.12986
79047-79063
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Synergistic targeting of Sp1 a critical transcription factor for myeloma cell growth and survival by panobinostat and proteasome inhibitors

https://doi.org/10.18632/oncotarget.12594
79064-79075
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Antitumor activity of curcumin is involved in downregulation of YAP/TAZ expression in pancreatic cancer cells

https://doi.org/10.18632/oncotarget.12596
79076-79088
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Radiosensitizing effect of lapatinib in human epidermal growth factor receptor 2positive breast cancer cells

https://doi.org/10.18632/oncotarget.12597
79089-79100
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

https://doi.org/10.18632/oncotarget.12600
79101-79116
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy

https://doi.org/10.18632/oncotarget.12997
79117-79130
Abstract  |  PDF  |  Full Text  |  How to cite

Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke

https://doi.org/10.18632/oncotarget.12998
79131-79140
Abstract  |  PDF  |  Full Text  |  How to cite

Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism

https://doi.org/10.18632/oncotarget.13003
79141-79153
Abstract  |  PDF  |  Full Text  |  How to cite

Proteomic analysis reveals diverse proline hydroxylationmediated oxygensensing cellular pathways in cancer cells

https://doi.org/10.18632/oncotarget.12632
79154-79169
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Antimetastatic effect of the TM4SF5specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

https://doi.org/10.18632/oncotarget.13005
79170-79186
Abstract  |  PDF  |  Full Text  |  How to cite

The antitumor role of NK cells in vivo preactivated and restimulated by interleukins in acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.13007
79187-79202
Abstract  |  PDF  |  Full Text  |  How to cite

Spatiotemporal regulation of EGFR signaling by the Eps15 homology domaincontaining protein 3 EHD3

https://doi.org/10.18632/oncotarget.13008
79203-79216
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinonecontaining compounds and antimicrotubule drugs

https://doi.org/10.18632/oncotarget.12640
79217-79232
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Genetic interactions between the hedgehog coreceptors Gas1 and Boc regulate cell proliferation during murine palatogenesis

https://doi.org/10.18632/oncotarget.13011
79233-79246
Abstract  |  PDF  |  Full Text  |  How to cite

Resveratrol posttreatment protects against neonatal brain injury after hypoxiaischemia

https://doi.org/10.18632/oncotarget.13018
79247-79261
Abstract  |  PDF  |  Full Text  |  How to cite

Notch1WISP1 axis determines the regulatory role of mesenchymal stem cellderived stromal fibroblasts in melanoma metastasis

https://doi.org/10.18632/oncotarget.13021
79262-79273
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Differentially expressed miRNAs in triple negative breast cancer between AfricanAmerican and nonHispanic white women

https://doi.org/10.18632/oncotarget.13024
79274-79291
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation

https://doi.org/10.18632/oncotarget.12685
79292-79304
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Lentivirusmediated RNAi knockdown of insulinlike growth factor1 receptor inhibits the growth and invasion of hepatocellular carcinoma via downregulating midkine expression

https://doi.org/10.18632/oncotarget.13027
79305-79318
Abstract  |  PDF  |  Full Text  |  How to cite

Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis

https://doi.org/10.18632/oncotarget.12686
79319-79326
Abstract  |  PDF  |  Full Text  |  How to cite

Preclinical activity of MBM5 in gastrointestinal cancer by inhibiting NEK2 kinase activity

https://doi.org/10.18632/oncotarget.12687
79327-79341
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

DNMT3B in vitro knockingdown is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

https://doi.org/10.18632/oncotarget.12688
79342-79356
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Intravoxel incoherent motion IVIM in diffusionweighted imaging DWI for Hepatocellular carcinoma: correlation with histologic grade

https://doi.org/10.18632/oncotarget.12689
79357-79364
Abstract  |  PDF  |  Full Text  |  How to cite

Association between miR199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.13033
79365-79371
Abstract  |  PDF  |  Full Text  |  How to cite

A combined gene expression and functional study reveals the crosstalk between NMyc and differentiationinducing microRNAs in neuroblastoma cells

https://doi.org/10.18632/oncotarget.12676
79372-79387
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

ON 01910Na rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals in head and neck cancer cell lines

https://doi.org/10.18632/oncotarget.12692
79388-79400
Abstract  |  PDF  |  Full Text  |  How to cite

Delivery of a peptidedrug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma

https://doi.org/10.18632/oncotarget.12708
79401-79407
Abstract  |  PDF  |  Full Text  |  How to cite

Nearinfrared photoimmunotherapy with galactosyl serum albumin in a model of diffuse peritoneal disseminated ovarian cancer

https://doi.org/10.18632/oncotarget.12710
79408-79416
Abstract  |  PDF  |  Full Text  |  How to cite

Identification of DNAPKcs as a primary resistance factor of salinomycin in osteosarcoma cells

https://doi.org/10.18632/oncotarget.12712
79417-79427
Abstract  |  PDF  |  Full Text  |  How to cite

Targeted NGS arrayCGH and patientderived tumor xenografts for precision medicine in advanced breast cancer: a singlecenter prospective study

https://doi.org/10.18632/oncotarget.12714
79428-79441
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Effect of marital status on the survival of patients with hepatocellular carcinoma treated with surgical resection: an analysis of 13408 patients in the surveillance epidemiology and end results SEER database

https://doi.org/10.18632/oncotarget.12722
79442-79452
Abstract  |  PDF  |  Full Text  |  How to cite

Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method

https://doi.org/10.18632/oncotarget.13100
79453-79473
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Utilization of leukapheresis and CD4 positive selection in Treg isolation and the exvivo expansion for a clinical application in transplantation and autoimmune disorders

https://doi.org/10.18632/oncotarget.13101
79474-79484
Abstract  |  PDF  |  Full Text  |  How to cite

OutLyzer: software for extracting lowallelefrequency tumor mutations from sequencing background noise in clinical practice

https://doi.org/10.18632/oncotarget.13103
79485-79493
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Identification of KLK10 as a therapeutic target to reverse trastuzumab resistance in breast cancer

https://doi.org/10.18632/oncotarget.13104
79494-79502
Abstract  |  PDF  |  Full Text  |  How to cite

KRASmutation status dependent effect of zoledronic acid in human nonsmall cell cancer preclinical models

https://doi.org/10.18632/oncotarget.12806
79503-79514
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Deubiquitinase USP9X deubiquitinates βcatenin and promotes high grade glioma cell growth

https://doi.org/10.18632/oncotarget.12819
79515-79525
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK cotargeted inhibition strategy in NSCLC

https://doi.org/10.18632/oncotarget.12755
79526-79543
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

WM130 preferentially inhibits hepatic cancer stemlike cells by suppressing AKT/GSK3β/βcatenin signaling pathway

https://doi.org/10.18632/oncotarget.12822
79544-79556
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Epigallocatechin3gallateEGCG suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

https://doi.org/10.18632/oncotarget.12836
79557-79571
Abstract  |  PDF  |  Full Text  |  How to cite

Stimulation of prolactin receptor induces STAT5 phosphorylation and cellular invasion in glioblastoma multiforme

https://doi.org/10.18632/oncotarget.12840
79572-79583
Abstract  |  PDF  |  Full Text  |  How to cite

MicroRNA101 reverses temozolomide resistance by inhibition of GSK3β in glioblastoma

https://doi.org/10.18632/oncotarget.12861
79584-79595
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival

https://doi.org/10.18632/oncotarget.12865
79596-79604
Abstract  |  PDF  |  Full Text  |  How to cite

Comparison of the expression and function of Lin28A and Lin28B in colon cancer

https://doi.org/10.18632/oncotarget.12869
79605-79616
Abstract  |  PDF  |  Full Text  |  How to cite

miR31 affects colorectal cancer cells by inhibiting autophagy in cancerassociated fibroblasts

https://doi.org/10.18632/oncotarget.12873
79617-79628
Abstract  |  PDF  |  Full Text  |  How to cite

Multiple mutations of lung squamous cell carcinoma shared common mechanisms

https://doi.org/10.18632/oncotarget.13190
79629-79636
Abstract  |  PDF  |  Full Text  |  How to cite

Therapeutic efficacy of the bromodomain inhibitor OTX015/MK8628 in ALKpositive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes

https://doi.org/10.18632/oncotarget.12876
79637-79653
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

SIRT1 promotes metastasis of human osteosarcoma cells

https://doi.org/10.18632/oncotarget.12916
79654-79669
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Enhancement of 5FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

https://doi.org/10.18632/oncotarget.13216
79670-79687
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Breast cancer cells obtain an osteomimetic feature via epithelialmesenchymal transition that have undergone BMP2/RUNX2 signaling pathway induction

https://doi.org/10.18632/oncotarget.12939
79688-79705
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes

https://doi.org/10.18632/oncotarget.12941
79706-79721
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

https://doi.org/10.18632/oncotarget.12944
79722-79735
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Glypican5 suppresses EpithelialMesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a

https://doi.org/10.18632/oncotarget.12945
79736-79746
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Nickel chlorideinduced apoptosis via mitochondria and Fasmediated caspasedependent pathways in broiler chickens

https://doi.org/10.18632/oncotarget.12946
79747-79760
Abstract  |  PDF  |  Full Text  |  How to cite

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinasemediated signaling pathway in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.12962
79761-79773
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis

https://doi.org/10.18632/oncotarget.12967
79774-79786
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

The survival and clinicopathological differences between patients with stage IIIA and stage II rectal cancer: An analysis of 12036 patients in the SEER database

https://doi.org/10.18632/oncotarget.12970
79787-79796
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Novel mutations in CRB1 gene identified in a chinese pedigree with retinitis pigmentosa by targeted capture and next generation sequencing

https://doi.org/10.18632/oncotarget.12971
79797-79804
Abstract  |  PDF  |  Full Text  |  How to cite

MicroRNA206 attenuates the growth and angiogenesis in nonsmall cell lung cancer cells by blocking the 1433ζ/STAT3/HIF1α/VEGF signaling

https://doi.org/10.18632/oncotarget.12972
79805-79813
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Orthoreovirus outerfiber proteins are substrates for SUMOconjugating enzyme Ubc9

https://doi.org/10.18632/oncotarget.12973
79814-79827
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Recombinant oncolytic poliovirus PVSRIPO has potent cytotoxic and innate inflammatory effects mediating therapy in human breast and prostate cancer xenograft models

https://doi.org/10.18632/oncotarget.12975
79828-79841
Abstract  |  PDF  |  Full Text  |  How to cite

Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214ABL1 fusion protein in human Acute Lymphoblastic Leukemia

https://doi.org/10.18632/oncotarget.13035
79842-79853
Abstract  |  PDF  |  Full Text  |  How to cite

TRIM71 suppresses tumorigenesis via modulation of Lin28Blet7HMGA2 signaling

https://doi.org/10.18632/oncotarget.13036
79854-79868
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics

https://doi.org/10.18632/oncotarget.13084
79869-79884
Abstract  |  PDF  |  Full Text  |  How to cite

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport

https://doi.org/10.18632/oncotarget.13089
79885-79900
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Tumor necrosis factoralpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a metaanalysis

https://doi.org/10.18632/oncotarget.13093
79901-79913
Abstract  |  PDF  |  Full Text  |  How to cite

Interleukin13 suppresses interleukin10 via inhibiting A20 in peripheral B cells of patients with food allergy

https://doi.org/10.18632/oncotarget.13107
79914-79924
Abstract  |  PDF  |  Full Text  |  How to cite

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF1R/RAS/Rac1 signaling

https://doi.org/10.18632/oncotarget.13160
79925-79942
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

PDL1 promoter methylation is a prognostic biomarker for biochemical recurrencefree survival in prostate cancer patients following radical prostatectomy

https://doi.org/10.18632/oncotarget.13161
79943-79955
Abstract  |  PDF  |  Full Text  |  How to cite

miR186 affects the proliferation invasion and migration of human gastric cancer by inhibition of Twist1

https://doi.org/10.18632/oncotarget.13182
79956-79963
Abstract  |  PDF  |  Full Text  |  How to cite

Motor activity of centromereassociated proteinE contributes to its localization at the center of the midbody to regulate cytokinetic abscission

https://doi.org/10.18632/oncotarget.13206
79964-79980
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Establishment of mitochondrial pyruvate carrier 1 MPC1 gene knockout mice with preliminary gene function analyses

https://doi.org/10.18632/oncotarget.13210
79981-79994
Abstract  |  PDF  |  Full Text  |  How to cite

Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells

https://doi.org/10.18632/oncotarget.13237
79995-80007
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Biodegradable doubletargeted PTXmPEGPLGA nanoparticles for ultrasound contrast enhanced imaging and antitumor therapy in vitro

https://doi.org/10.18632/oncotarget.13243
80008-80018
Abstract  |  PDF  |  Full Text  |  How to cite

Diagnostic accuracy of DNA methylation for head and neck cancer varies by sample type and number of markers tested

https://doi.org/10.18632/oncotarget.12219
80019-80032
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

New combined microRNA and protein plasmatic biomarker panel for pancreatic cancer

https://doi.org/10.18632/oncotarget.12406
80033-80045
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Clinical Research Papers

Firstinhuman phase I clinical trial of RG7356 an antiCD44 humanized antibody in patients with advanced CD44expressing solid tumors

https://doi.org/10.18632/oncotarget.11098
80046-80058
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Serological immune response against ADAM10 prodomain is associated with favourable prognosis in stage III colorectal cancer patients

https://doi.org/10.18632/oncotarget.11181
80059-80076
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results

https://doi.org/10.18632/oncotarget.11374
80077-80082
Abstract  |  PDF  |  Full Text  |  How to cite

Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate toxicity and outcome

https://doi.org/10.18632/oncotarget.11657
80083-80090
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite

Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma

https://doi.org/10.18632/oncotarget.11756
80091-80100
Abstract  |  PDF  |  Full Text  |  Supplementary Information  |  How to cite


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